2022
Lecanemab in Early Alzheimer’s Disease
van Dyck C, Swanson C, Aisen P, Bateman R, Chen C, Gee M, Kanekiyo M, Li D, Reyderman L, Cohen S, Froelich L, Katayama S, Sabbagh M, Vellas B, Watson D, Dhadda S, Irizarry M, Kramer L, Iwatsubo T. Lecanemab in Early Alzheimer’s Disease. New England Journal Of Medicine 2022, 388: 9-21. PMID: 36449413, DOI: 10.1056/nejmoa2212948.Peer-Reviewed Original ResearchConceptsEarly Alzheimer's diseasePositron emission tomographyDisease Assessment ScaleAlzheimer's diseaseAmyloid burdenAlzheimer's Disease Cooperative Study-ActivitiesAmyloid-related imaging abnormalitiesKey secondary end pointEnd pointAlzheimer's Disease Assessment ScaleClinical Dementia Rating SumHumanized IgG1 monoclonal antibodyMarkers of amyloidInfusion-related reactionsPrimary end pointSecondary end pointsCerebrospinal fluid testingPhase 3 trialBrain amyloid burdenDaily Living ScaleEvidence of amyloidCDR-SB scoresYears of ageMild cognitive impairmentIgG1 monoclonal antibody
2012
IC‐O1‐03: Amyloid burden and neuropsychological performance in presymptomatic first‐degree relatives at varying APOE‐ɛ4 risk for Alzheimer's disease
van Dyck C, Barcelos N, Brück A, Planeta‐Wilson B, Gelernter J, Carson R. IC‐O1‐03: Amyloid burden and neuropsychological performance in presymptomatic first‐degree relatives at varying APOE‐ɛ4 risk for Alzheimer's disease. Alzheimer's & Dementia 2012, 8: p5-p5. DOI: 10.1016/j.jalz.2012.05.018.Peer-Reviewed Original Research