2022
Can transfusion-associated graft-versus-host disease (TA-GvHD) be prevented with leukoreduction alone?
Rodriguez JV, Tormey CA. Can transfusion-associated graft-versus-host disease (TA-GvHD) be prevented with leukoreduction alone? Transfusion And Apheresis Science 2022, 61: 103402. PMID: 35288056, DOI: 10.1016/j.transci.2022.103402.Peer-Reviewed Original ResearchMeSH KeywordsBlood TransfusionGraft vs Host DiseaseHumansLeukocyte CountLeukocytesTransfusion ReactionConceptsTransfusion-associated graftTA-GVHDHost diseaseCellular blood productsHigh mortality rateWhite blood cellsBlood productsEffective treatmentMortality rateTransfusion communityHigh mortalityMedical literatureBlood cellsDiseaseDevastating diseaseGraftLeukocytesLeukoreductionQuantitative reductionHospitalMortality
2020
Patient monitoring during transfusion: Does computerization hold the key to improving an age‐old practice?
Gehrie EA, Tormey CA. Patient monitoring during transfusion: Does computerization hold the key to improving an age‐old practice? Transfusion 2020, 60: 1888-1890. PMID: 33460168, DOI: 10.1111/trf.16030.Peer-Reviewed Original ResearchMeSH KeywordsBlood TransfusionElectronicsHumansMonitoring, PhysiologicTransfusion ReactionVital SignsPassive anti‐C acquired in the setting of Rh immune globulin administration following Rh mismatched apheresis platelet transfusion: A case series
Sostin N, Ross R, Balbuena‐Merle R, Hendrickson JE, Tormey CA. Passive anti‐C acquired in the setting of Rh immune globulin administration following Rh mismatched apheresis platelet transfusion: A case series. Journal Of Clinical Apheresis 2020, 35: 224-226. PMID: 32110829, DOI: 10.1002/jca.21773.Peer-Reviewed Original ResearchConceptsPlatelet transfusionsRh immune globulin administrationRisk/benefit ratioApheresis platelet transfusionImmune globulin administrationRhIG immunoprophylaxisImmune globulinTransfusion supportAlloantibody formationCase seriesNegative recipientsAlloimmunization riskRhIG administrationReproductive agePassive transferPLT transfusionsTransfusionBlood bankBenefit ratioRhIGApheresis PLTsAdministrationImmunoprophylaxisPatientsSetting
2019
Fatal acute hemolytic transfusion reaction due to anti‐B from a platelet apheresis unit stored in platelet additive solution
Balbuena‐Merle R, West FB, Tormey CA, Hendrickson JE. Fatal acute hemolytic transfusion reaction due to anti‐B from a platelet apheresis unit stored in platelet additive solution. Transfusion 2019, 59: 1911-1915. PMID: 30865314, DOI: 10.1111/trf.15240.Peer-Reviewed Original ResearchConceptsGroup B patientsHemolytic transfusion reactionsDirect antiglobulin testB patientsTransfusion reactionsApheresis unitsBlood group B patientsRelapsed acute myeloid leukemiaAcute hemolytic transfusion reactionAnti-human globulin phaseHigh lactate dehydrogenaseAnti-human globulinAcute myeloid leukemiaRecipient testingDonor testingRecipient variablesExtravascular hemolysisPlatelet transfusionsTransfusion recipientsAntibody screenHigh bilirubinPLT transfusionsAntiglobulin testBlood productsMyeloid leukemiaTransfusion-related red blood cell alloantibodies: induction and consequences
Tormey CA, Hendrickson JE. Transfusion-related red blood cell alloantibodies: induction and consequences. Blood 2019, 133: 1821-1830. PMID: 30808636, PMCID: PMC6484385, DOI: 10.1182/blood-2018-08-833962.Peer-Reviewed Original ResearchMeSH KeywordsABO Blood-Group SystemBlood Group IncompatibilityErythrocyte TransfusionErythrocytesHumansIsoantibodiesTransfusion ReactionConceptsTransfusion recipientsBlood donorsPreventative strategiesBlood product exposureCompatible RBC unitsRBC alloantibody formationHemolytic transfusion reactionsDevelopment of alloantibodiesAdaptive immune factorsJudicious transfusionRBC alloimmunizationImmunomodulatory therapyAlloantibody formationBlood transfusionRBC alloantibodiesRecipient variablesFuture pregnanciesImmune factorsTransfusion reactionsBlood productsHemolytic diseaseFuture transfusionsHuman studiesTransfusionAlloantibodies
2018
Prevention of Transfusion-Associated Graft-Versus-Host Disease With Blood Product Irradiation: The Past, Present, and Future
Bahar B, Tormey CA. Prevention of Transfusion-Associated Graft-Versus-Host Disease With Blood Product Irradiation: The Past, Present, and Future. Archives Of Pathology & Laboratory Medicine 2018, 142: 662-667. PMID: 29684286, DOI: 10.5858/arpa.2016-0620-rs.Peer-Reviewed Original ResearchRisk factors for red blood cell alloimmunization in the Recipient Epidemiology and Donor Evaluation Study (REDS‐III) database
Karafin MS, Westlake M, Hauser RG, Tormey CA, Norris PJ, Roubinian NH, Wu Y, Triulzi DJ, Kleinman S, Hendrickson JE, Study‐III N. Risk factors for red blood cell alloimmunization in the Recipient Epidemiology and Donor Evaluation Study (REDS‐III) database. British Journal Of Haematology 2018, 181: 672-681. PMID: 29675950, PMCID: PMC5991618, DOI: 10.1111/bjh.15182.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAnemia, Sickle CellArthritis, RheumatoidBlood DonorsBlood Group AntigensChildChild, PreschoolDatabases, FactualErythrocyte TransfusionFemaleHumansImmunizationInfantIsoantibodiesLupus Erythematosus, SystemicMaleMiddle AgedMyelodysplastic SyndromesRisk FactorsTransfusion ReactionConceptsRed blood cell alloimmunizationRecipient EpidemiologyRecipients databaseSignificant RBC alloantibodiesNegative antibody screenLargest RBCStandardized registryPositive patientsRBC alloantibodiesAntibody screenICD9/10 codesPatient cohortRisk factorsResponder statusCertain diagnosisBlood typeLarger studyAlloimmunizationRhD statusStudy databaseRespondersPatientsDisease associationsPotential correlatesEpidemiology
2017
A novel association between high red blood cell alloimmunization rates and hereditary hemorrhagic telangiectasia
Zheng Y, Pollak J, Henderson K, Hendrickson JE, Tormey CA. A novel association between high red blood cell alloimmunization rates and hereditary hemorrhagic telangiectasia. Transfusion 2017, 58: 775-780. PMID: 29210083, DOI: 10.1111/trf.14451.Peer-Reviewed Original ResearchMeSH KeywordsBlood Group AntigensErythrocyte TransfusionFemaleHumansIsoantibodiesMaleTelangiectasia, Hereditary HemorrhagicTransfusion ReactionConceptsHereditary hemorrhagic telangiectasiaRBC alloimmunization rateAlloimmunization rateHHT patientsRBC transfusionHemorrhagic telangiectasiaRed blood cell transfusionProphylactic antigen matchingBlood cell transfusionTertiary care facilityMultiple arteriovenous malformationsAutosomal dominant disorderCommon alloantibodiesHHT populationCell transfusionSurgical bleedingTransfusion burdenAntigen matchingSpontaneous hemorrhageRetrospective studyMedical recordsArteriovenous malformationsCare facilitiesPatientsDisease pathophysiology
2016
Red blood cell alloimmunization
Hendrickson JE, Eisenbarth SC, Tormey CA. Red blood cell alloimmunization. Current Opinion In Hematology 2016, 23: 543-549. PMID: 27454234, DOI: 10.1097/moh.0000000000000277.Peer-Reviewed Original ResearchConceptsAlloimmune responseChronic red blood cell transfusionsRed blood cell transfusionRed blood cell alloimmunizationHuman leukocyte antigen (HLA) expressionBlood cell transfusionT-cell markersRecent animal studiesResult of pregnancyRecipient inflammationSuch alloimmunizationCell transfusionDendritic cellsClinical studiesAntigen expressionImmune responseAlloimmunizationAnimal modelsAnimal studiesRBC antigensBlood groupHigher likelihoodTransfusionAdditional associationsHigh rateDetection rate of blood group alloimmunization based on real‐world testing practices and kinetics of antibody induction and evanescence
Stack G, Tormey CA. Detection rate of blood group alloimmunization based on real‐world testing practices and kinetics of antibody induction and evanescence. Transfusion 2016, 56: 2662-2667. PMID: 27394029, DOI: 10.1111/trf.13704.Peer-Reviewed Original ResearchConceptsAntibody inductionAntibody testingAlloantibody detectionRed blood cell transfusionNon-ABO antibodiesBlood cell transfusionGeneral hospital settingBlood group alloantibodiesDetection rateRBC infusionCell transfusionRBC transfusionAntibody screenDays posttransfusionMismatched transfusionHospital settingTransfusionHemolytic reactionRBC unitsStudy designTesting practicesAlloantibodiesAlloimmunizationPatientsOne-thirdEstimating the immunogenicity of blood group antigens: a modified calculation that corrects for transfusion exposures
Stack G, Tormey CA. Estimating the immunogenicity of blood group antigens: a modified calculation that corrects for transfusion exposures. British Journal Of Haematology 2016, 175: 154-160. PMID: 27340943, DOI: 10.1111/bjh.14175.Peer-Reviewed Original ResearchMeSH KeywordsAntibody SpecificityBlood Group AntigensHumansImmunityImmunoglobulin GIsoantibodiesModels, StatisticalTransfusion ReactionConceptsAntigen immunogenicityPre-existing antibodiesLow-frequency antigensMean RBCHigh-frequency antigensHospital transfusion servicesTransfusion exposureAntibody frequencyAntigen exposureRBC exposureTransfusion servicesImmunogenicityRBC unitsAntigenPatientsBlood groupReference antigenUnit exposureExposureFold increaseSmall increaseRed Blood Cell Antibodies in Hematology/Oncology Patients Interpretation of Immunohematologic Tests and Clinical Significance of Detected Antibodies
Hendrickson JE, Tormey CA. Red Blood Cell Antibodies in Hematology/Oncology Patients Interpretation of Immunohematologic Tests and Clinical Significance of Detected Antibodies. Hematology/Oncology Clinics Of North America 2016, 30: 635-651. PMID: 27113001, DOI: 10.1016/j.hoc.2016.01.006.Peer-Reviewed Original ResearchMeSH KeywordsAnemia, Hemolytic, AutoimmuneBlood BanksBlood Group AntigensBlood Group IncompatibilityErythrocytesHumansIsoantibodiesNeoplasmsTransfusion ReactionConceptsRed blood cell transfusionRed blood cell antibodiesRBC alloimmunization rateBlood cell transfusionManagement of patientsDevelopment of alloantibodiesBlood group antigensAlloimmunization rateRBC alloimmunizationSuch alloantibodiesCell transfusionCell antibodiesClinical significanceHemolytic anemiaPatients' interpretationsDetected antibodiesTransfusionGroup antigensBlood bankCompatible unitsAntibodiesAlloantibodiesOncology disordersDeleterious consequencesAlloimmunization
2015
Variation in vital signs resulting from blood component administration in adults
Gehrie EA, Hendrickson JE, Tormey CA. Variation in vital signs resulting from blood component administration in adults. Transfusion 2015, 55: 1866-1871. PMID: 25867097, DOI: 10.1111/trf.13060.Peer-Reviewed Original Research
2013
The Development of a Novel Molecular Assay Examining the Role of Aminopeptidase P Polymorphisms in Acute Hypotensive Transfusion Reactions
Hui Y, Wu Y, Tormey CA. The Development of a Novel Molecular Assay Examining the Role of Aminopeptidase P Polymorphisms in Acute Hypotensive Transfusion Reactions. Archives Of Pathology & Laboratory Medicine 2013, 137: 96-9. PMID: 23276181, DOI: 10.5858/arpa.2011-0466-oa.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdolescentAgedAminopeptidasesAngiotensin-Converting Enzyme InhibitorsBase SequenceBradykininCase-Control StudiesDNA PrimersFemaleGenetic Predisposition to DiseaseHeterozygoteHomozygoteHumansHypotensionMaleMiddle AgedPolymerase Chain ReactionPolymorphism, Single NucleotideTransfusion ReactionConceptsAcute hypotensive transfusion reactionsHypotensive transfusion reactionsACE-IsTransfusion reactionsSingle nucleotide polymorphismsMolecular assaysHarmful adverse effectsPolymerase chain reactionBradykinin degradationPatientsEnzyme inhibitorsBradykinin generationAPP geneNovel molecular assayPilot studyAdverse effectsChain reactionFurther studiesAminopeptidase PXPNPEP2PolymorphismAssaysAPP activitySequencing resultsTransfusion
2009
Clinical trials for pathogen reduction in transfusion medicine: A review
McClaskey J, Xu M, Snyder EL, Tormey CA. Clinical trials for pathogen reduction in transfusion medicine: A review. Transfusion And Apheresis Science 2009, 41: 217-225. PMID: 19793679, DOI: 10.1016/j.transci.2009.09.008.Peer-Reviewed Original ResearchMeSH KeywordsBlood TransfusionBlood-Borne PathogensClinical Trials as TopicDisinfectantsDisinfectionHumansInfection ControlTransfusion ReactionVirus InactivationConceptsClinical trialsBlood productsDonor screening programsDonor blood productsRisk of transmissionInfective donorsTransfusion recipientsScreening programClinical settingInfectious diseasesTransfusion medicineTesting regimensPI treatmentTrialsScreening assaysRiskPathogensPotential toxicityPromising strategyDetection of pathogensRegimensPathogen reductionSensitive methodDiseaseRecipientsImmunogenicity of blood group antigens: a mathematical model corrected for antibody evanescence with exclusion of naturally occurring and pregnancy-related antibodies
Tormey CA, Stack G. Immunogenicity of blood group antigens: a mathematical model corrected for antibody evanescence with exclusion of naturally occurring and pregnancy-related antibodies. Blood 2009, 114: 4279-4282. PMID: 19713462, DOI: 10.1182/blood-2009-06-227793.Peer-Reviewed Original ResearchMeSH KeywordsBlood Group AntigensFemaleHumansImmunity, InnateIsoantibodiesMaleMathematical ConceptsModels, ImmunologicalPregnancyTransfusion ReactionEstimation of Combat-Related Blood Group Alloimmunization and Delayed Serologic Transfusion Reactions in U.S. Military Veterans
Tormey CA, Stack G. Estimation of Combat-Related Blood Group Alloimmunization and Delayed Serologic Transfusion Reactions in U.S. Military Veterans. Military Medicine 2009, 174: 503-507. PMID: 20731281, DOI: 10.7205/milmed-d-02-5808.Peer-Reviewed Original ResearchConceptsSerologic transfusion reactionsTransfusion reactionsVeterans Affairs Medical CenterAnamnestic immune responseMilitary veteran patientsBlood group alloantibodiesMilitary veteransPre-existing antibodiesU.S. military veteransAlloimmunization ratePrior alloimmunizationVeteran patientsTransfusion recordsVA careImmune responseMedical CenterAlloimmunizationAlloantibodiesVeteransAntibodiesHigh rateTransfusionPatientsPrevalenceCare