2020
The use of 4F‐PCC to correct direct oral anticoagulant‐induced coagulopathy: An observational analysis
Zheng Y, Tormey CA. The use of 4F‐PCC to correct direct oral anticoagulant‐induced coagulopathy: An observational analysis. Transfusion Medicine 2020, 30: 304-307. PMID: 32342588, DOI: 10.1111/tme.12683.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAgedAged, 80 and overAnticoagulantsBlood Coagulation FactorsFemaleHemorrhageHumansMaleMiddle AgedRetrospective StudiesConceptsDirect oral anticoagulantsThromboembolic eventsFour-factor prothrombin complex concentrateLevel 1 trauma centerAdditional prospective studiesRetrospective observational studyProthrombin complex concentrateOff-label useEmergent surgeryOral anticoagulantsMost patientsClinical outcomesTrauma centerHgb levelsProspective studyLabel indicationsComplex concentrateSevere hemorrhageObservational studyHemorrhage sizePatientsCoagulopathyAdministrationBleedingHemorrhage
2015
Novel Oral Anticoagulants: Efficacy, Laboratory Measurement, and Approaches to Emergent Reversal
Gehrie E, Tormey C. Novel Oral Anticoagulants: Efficacy, Laboratory Measurement, and Approaches to Emergent Reversal. Archives Of Pathology & Laboratory Medicine 2015, 139: 687-92. PMID: 25927153, DOI: 10.5858/arpa.2013-0677-rs.Peer-Reviewed Original ResearchConceptsNovel oral anticoagulantsManagement of NOACOral direct thrombin inhibitorDirect factor Xa inhibitorVitamin K antagonistsDirect thrombin inhibitorFactor Xa inhibitorsCertain clinical circumstancesOral anticoagulationWarfarin effectivenessK antagonistsOral anticoagulantsClinical efficacySafety profileEmergent reversalClinical circumstancesXa inhibitorsUS FoodDrug AdministrationThrombin inhibitorsNew drugsDrugsEfficacyInhibitorsLaboratory assays