2024
A multi‐institutional survey of apheresis services among institutions in the United States
Yurtsever N, Jacobs J, Booth G, Schwartz J, Park Y, Woo J, Lauro D, Torres S, Ward D, Stephens L, Allen E, Tormey C, Adkins B. A multi‐institutional survey of apheresis services among institutions in the United States. Journal Of Clinical Apheresis 2024, 39: e22138. PMID: 38979705, DOI: 10.1002/jca.22138.Peer-Reviewed Original ResearchMeSH KeywordsBlood Component RemovalCOVID-19HumansPandemicsPlasma ExchangeSARS-CoV-2Surveys and QuestionnairesUnited StatesConceptsTherapeutic plasma exchangeRed blood cell exchangeCell collectionSpectra Optia apheresis systemMulti-institutional surveyHematopoietic progenitor cell collectionProgenitor cell collectionUS academic centersCAR-TPlasma exchangeApheresis therapyGene therapyTransfusion medicine serviceCellular therapyApheresis practiceApheresis systemCell exchangeAcademic medical centerClinical trialsAcademic centersHPC-AApheresisMedical CenterTherapyCoronavirus disease 2019
2021
Therapeutic plasma exchange for peripheral neuropathy associated with trisulfated heparan disaccharide IgM antibodies: A case series of 17 patients
Olsen GM, Tormey CA, Tseng B, Hendrickson JE, Sostin N. Therapeutic plasma exchange for peripheral neuropathy associated with trisulfated heparan disaccharide IgM antibodies: A case series of 17 patients. Journal Of Clinical Apheresis 2021, 37: 13-18. PMID: 34698404, DOI: 10.1002/jca.21944.Peer-Reviewed Original ResearchConceptsTherapeutic plasma exchangeSmall fiber neuropathyAdverse eventsPlasma exchangeLower extremity paresthesiasSymptomatic response rateAutoantibody-mediated disorderSkin biopsy resultsSFN symptomsTS-HDSExtremity paresthesiasPeripheral neuropathySymptomatic improvementCase seriesIgM antibodiesMean ageTPE proceduresBiopsy resultsTreatment optionsDisease progressionIgM classVasovagal reactionsClose monitoringLaboratory confirmationResponse rateCost effectiveness of caplacizumab in acquired thrombotic thrombocytopenic purpura
Goshua G, Sinha P, Hendrickson J, Tormey C, Bendapudi PK, Lee AI. Cost effectiveness of caplacizumab in acquired thrombotic thrombocytopenic purpura. Blood 2021, 137: 969-976. PMID: 33280030, PMCID: PMC7918179, DOI: 10.1182/blood.2020006052.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedClinical Trials, Phase II as TopicClinical Trials, Phase III as TopicCombined Modality TherapyCost-Benefit AnalysisDecision TreesDrug CostsDrug Therapy, CombinationFemaleFibrinolytic AgentsHemorrhageHumansImmunosuppressive AgentsLength of StayMaleMarkov ChainsMiddle AgedModels, EconomicMulticenter Studies as TopicPlasma ExchangePurpura, Thrombotic ThrombocytopenicRecurrenceRituximabSingle-Domain AntibodiesStandard of CareUnited StatesYoung AdultConceptsIncremental cost-effectiveness ratioThrombotic thrombocytopenic purpuraTherapeutic plasma exchangeVon Willebrand factorRelapse rateThrombocytopenic purpuraClinical trialsMajor randomized clinical trialsThrombotic microangiopathy leadingEnd-organ damageWillebrand factorPlatelet count recoveryRandomized clinical trialsHealth system costsOne-way sensitivity analysesCost-effectiveness ratioLife-threatening diseaseProbabilistic sensitivity analysesCost-effectiveness analysisHospital lengthCount recoveryPlasma exchangeTPE treatmentTTP patientsImmunomodulatory agents
2020
Application of PLASMIC score in prediction of ADAMTS13 deficiency in a pediatric case of acquired thrombotic thrombocytopenic purpura
Gupta GK, Hendrickson JE, Tormey CA. Application of PLASMIC score in prediction of ADAMTS13 deficiency in a pediatric case of acquired thrombotic thrombocytopenic purpura. Journal Of Clinical Apheresis 2020, 35: 140-141. PMID: 31951292, DOI: 10.1002/jca.21767.Peer-Reviewed Original Research
2019
Transfusion Medicine Equations Made Internet Accessible
Hauser RG, Kwon RJ, Ryder A, Cheng C, Charifa A, Tormey C. Transfusion Medicine Equations Made Internet Accessible. Transfusion Medicine Reviews 2019, 34: 5-9. PMID: 31785949, DOI: 10.1016/j.tmrv.2019.10.003.Peer-Reviewed Original Research
2017
Therapeutic Plasma Exchange and Its Impact on Drug Levels
Cheng CW, Hendrickson JE, Tormey CA, Sidhu D. Therapeutic Plasma Exchange and Its Impact on Drug Levels. American Journal Of Clinical Pathology 2017, 148: 190-198. PMID: 28821193, DOI: 10.1093/ajcp/aqx056.Peer-Reviewed Original ResearchConceptsTherapeutic plasma exchangePlasma exchangeCase reportDrug levelsCase seriesCochrane DatabaseMedication levelsPubMed-MedlineDefinitive guidelinesClinical propertiesAdditional studiesDevelopment of consensusDrug removalPeer-reviewed articlesAdditional investigationCurrent literatureTrialsReportClear needLiterature reviewOwn experiencePatientsLevels
2016
Two approaches to the clinical dilemma of treating TTP with therapeutic plasma exchange in patients with a history of anaphylactic reactions to plasma
Sidhu D, Snyder EL, Tormey CA. Two approaches to the clinical dilemma of treating TTP with therapeutic plasma exchange in patients with a history of anaphylactic reactions to plasma. Journal Of Clinical Apheresis 2016, 32: 158-162. PMID: 27246502, DOI: 10.1002/jca.21475.Peer-Reviewed Original ResearchConceptsTherapeutic plasma exchangeThrombotic thrombocytopenic purpuraSevere allergic reactionsAnaphylactic reactionsTTP exacerbationTTP remissionTreatment strategiesAllergic reactionsVon Willebrand factor (VWF) cleaving proteasePotential treatment strategyPossible treatment protocolReplacement plasmaAdverse eventsAcute treatmentPlasma exchangeThrombocytopenic purpuraSimilar patientsClinical dilemmaTreatment protocolAllergic riskPatientsDonor plasmaADAMTS-13Plasma productsStandard plasma
2015
Complex regional pain syndrome and dysautonomia in a 14‐year‐old girl responsive to therapeutic plasma exchange
Hendrickson JE, Hendrickson ET, Gehrie EA, Sidhu D, Wallukat G, Schimke I, Tormey CA. Complex regional pain syndrome and dysautonomia in a 14‐year‐old girl responsive to therapeutic plasma exchange. Journal Of Clinical Apheresis 2015, 31: 368-374. PMID: 26011726, DOI: 10.1002/jca.21407.Peer-Reviewed Original ResearchConceptsComplex regional pain syndromeTherapeutic plasma exchangeCRPS patientsLambert-Eaton myasthenic syndromeReflex sympathetic dystrophyRegional pain syndromeMuscarinic M2 receptorsΒ2-adrenergicAdditional immunosuppressionDetectable autoantibodiesLeg painNeuronal surface receptorsPain syndromeSympathetic dystrophyClinical responseVasomotor symptomsMyasthenia gravisReceptor autoantibodiesAppropriate therapyM2 receptorsPlasma exchangeAlbumin replacementMultiple therapiesEffective therapyMyasthenic syndrome
2014
The Development and Implementation of, and First Years' Experience With, a Massive/Emergency Transfusion Protocol (Damage Control Hematology Protocol) in a Veterans Affairs Hospital
Gehrie EA, Tormey CA. The Development and Implementation of, and First Years' Experience With, a Massive/Emergency Transfusion Protocol (Damage Control Hematology Protocol) in a Veterans Affairs Hospital. Military Medicine 2014, 179: 1099-1105. PMID: 25269127, DOI: 10.7205/milmed-d-14-00045.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBlood BanksBlood Grouping and CrossmatchingBlood Loss, SurgicalBlood TransfusionClinical AuditClinical ProtocolsConnecticutEmergenciesErythrocyte TransfusionFactor VIIaFactor VIIIFibrinogenHematemesisHospitals, VeteransHumansLaboratories, HospitalMalePlasma ExchangePlatelet TransfusionPostoperative HemorrhageRetrospective StudiesUnited StatesUnited States Department of Veterans AffairsConceptsFresh frozen plasmaRecombinant factor VIIaRed blood cellsVeterans Affairs hospitalTransfusion protocolFactor VIIaUnits of RBCsVeterans Affairs Connecticut Healthcare SystemUnits of FFPLarge trauma centersHospital-based blood banksETP patientsMassive transfusionTrauma centerFrozen plasmaSeparate patientsPatientsWest HavenBleeding emergenciesBlood bankBlood cellsYears' experienceHealthcare systemPlateletsHospital
2009
Improved plasma removal efficiency for therapeutic plasma exchange using a new apheresis platform
Tormey CA, Peddinghaus ME, Erickson M, King KE, Cushing MM, Bill J, Goodrich T, Snyder EL. Improved plasma removal efficiency for therapeutic plasma exchange using a new apheresis platform. Transfusion 2009, 50: 471-477. PMID: 19804570, DOI: 10.1111/j.1537-2995.2009.02412.x.Peer-Reviewed Original ResearchConceptsSignificant adverse eventsCellular countsPatients D-dimerPlasma-exchange programPlasma removal efficiencyTherapeutic plasma exchangePrimary outcome measureFluid balance measurementsComplement cascade activationPatient's coagulationSecondary outcomesAdverse eventsPlasma exchangeAnticoagulant usageD-dimerClinical trialsFluid replacementOutcome measuresFluid balanceCoagulation systemCOBE Spectra platformFree hemoglobinStudy designWaste plasmaNew apheresis device