2022
Assessment of polymicrobial interactions in bacterial isolates from transfused platelet units associated with sepsis
Kerantzas CA, Merwede J, Snyder EL, Hendrickson JE, Tormey CA, Kazmierczak BI, Peaper DR. Assessment of polymicrobial interactions in bacterial isolates from transfused platelet units associated with sepsis. Transfusion 2022, 62: 2458-2463. PMID: 36178430, PMCID: PMC11472026, DOI: 10.1111/trf.17136.Peer-Reviewed Original ResearchConceptsAcinetobacter calcoaceticus-baumannii complexBlood productsS. saprophyticusPlatelet unitsContaminated blood productsCDC investigationsApheresis platelet productsTransfusion reactionsPolymicrobial contaminationPlatelet productsDisease controlBacterial isolatesStudy designStaphylococcus saprophyticusPolymicrobial interactionsCDC casesSaprophyticusFuture studiesPotential interactionsCommon sourceSepsisIsolatesCasesCoaggregation
2019
Fatal acute hemolytic transfusion reaction due to anti‐B from a platelet apheresis unit stored in platelet additive solution
Balbuena‐Merle R, West FB, Tormey CA, Hendrickson JE. Fatal acute hemolytic transfusion reaction due to anti‐B from a platelet apheresis unit stored in platelet additive solution. Transfusion 2019, 59: 1911-1915. PMID: 30865314, DOI: 10.1111/trf.15240.Peer-Reviewed Original ResearchConceptsGroup B patientsHemolytic transfusion reactionsDirect antiglobulin testB patientsTransfusion reactionsApheresis unitsBlood group B patientsRelapsed acute myeloid leukemiaAcute hemolytic transfusion reactionAnti-human globulin phaseHigh lactate dehydrogenaseAnti-human globulinAcute myeloid leukemiaRecipient testingDonor testingRecipient variablesExtravascular hemolysisPlatelet transfusionsTransfusion recipientsAntibody screenHigh bilirubinPLT transfusionsAntiglobulin testBlood productsMyeloid leukemiaTransfusion-related red blood cell alloantibodies: induction and consequences
Tormey CA, Hendrickson JE. Transfusion-related red blood cell alloantibodies: induction and consequences. Blood 2019, 133: 1821-1830. PMID: 30808636, PMCID: PMC6484385, DOI: 10.1182/blood-2018-08-833962.Peer-Reviewed Original ResearchConceptsTransfusion recipientsBlood donorsPreventative strategiesBlood product exposureCompatible RBC unitsRBC alloantibody formationHemolytic transfusion reactionsDevelopment of alloantibodiesAdaptive immune factorsJudicious transfusionRBC alloimmunizationImmunomodulatory therapyAlloantibody formationBlood transfusionRBC alloantibodiesRecipient variablesFuture pregnanciesImmune factorsTransfusion reactionsBlood productsHemolytic diseaseFuture transfusionsHuman studiesTransfusionAlloantibodies
2018
Delayed haemolytic and serologic transfusion reactions
Siddon AJ, Kenney BC, Hendrickson JE, Tormey CA. Delayed haemolytic and serologic transfusion reactions. Current Opinion In Hematology 2018, 25: 459-467. PMID: 30124474, DOI: 10.1097/moh.0000000000000462.Peer-Reviewed Original ResearchConceptsSickle cell diseaseAdverse eventsTransfusion reactionsTransfusion-associated adverse eventsHaemolytic transfusion reactionsSerologic transfusion reactionsGeneral patient groupNovel immunosuppressive agentPractical preventive strategiesEvidence-based approachImmune dysregulationImmunosuppressive agentsPatient groupTransfusion recipientsRisk factorsBasic epidemiologyCell diseasePreventive strategiesRed blood cell deathAntibody detectionDHTRHaemolytic reactionsMultitude of reportsCell deathDHTRs
2017
How do we perform and bill for blood bank physician consultative services?
Jhang JS, Francis RO, Winkler A, Tormey C. How do we perform and bill for blood bank physician consultative services? Transfusion 2017, 57: 2311-2318. PMID: 28833250, DOI: 10.1111/trf.14264.Peer-Reviewed Original ResearchConceptsIndividual patientsTertiary care teaching hospitalCurrent Procedural Terminology codesPhysician servicesTransfusion medicine physiciansProcedural Terminology codesHealth care providersComponent therapyProvider educationTransfusion reactionsBlood productsTeaching hospitalClinical significanceInappropriate testingCare providersMedicine physiciansTerminology codesApheresis proceduresPatientsPhysiciansConsultative servicesLaboratory test resultsHealth careMedical servicesMedical direction
2014
Red Blood Cell Alloimmunization Mitigation Strategies
Hendrickson JE, Tormey CA, Shaz BH. Red Blood Cell Alloimmunization Mitigation Strategies. Transfusion Medicine Reviews 2014, 28: 137-144. PMID: 24928468, DOI: 10.1016/j.tmrv.2014.04.008.Peer-Reviewed Original ResearchConceptsHemolytic transfusion reactionsRBC alloantibodiesRBC alloimmunizationTransfusion reactionsImmune systemRed blood cell alloantibodiesCompatible RBC unitsRBC alloimmunization rateTransfusion-associated morbidityRecipient's immune systemTransfusion-associated deathForms of anemiaAlloimmunization rateAntigen exposureSignificant morbidityTransfusion recipientsHemolytic diseaseAlloantibodiesHuman studiesAnimal studiesDanger signalsAnimal dataMorbidityAlloimmunizationRBC units
2013
Allergic transfusion reactions to platelets are more commonly associated with prepooled than apheresis components
Xiao W, Tormey CA, Capetillo A, Maitta RW. Allergic transfusion reactions to platelets are more commonly associated with prepooled than apheresis components. Vox Sanguinis 2013, 105: 334-340. PMID: 23802769, DOI: 10.1111/vox.12063.Peer-Reviewed Original ResearchConceptsAllergic transfusion reactionsTransfusion reactionsATR rateApheresis plateletsPlatelet componentsApheresis componentsAcademic medical centerABO mismatchAdverse eventsAntigen exposurePlatelet transfusionsPlatelet countDonor factorsMedical CenterApheresis productsApheresis unitsPlatelet productsStudy periodTransfusionPlateletsSimilar ratesFurther investigationLimiting the Extent of a Delayed Hemolytic Transfusion Reaction With Automated Red Blood Cell Exchange
Tormey CA, Stack G. Limiting the Extent of a Delayed Hemolytic Transfusion Reaction With Automated Red Blood Cell Exchange. Archives Of Pathology & Laboratory Medicine 2013, 137: 861-4. PMID: 23721278, DOI: 10.5858/arpa.2012-0154-cr.Peer-Reviewed Original ResearchConceptsRed blood cell exchangeHemolytic transfusion reactionsDAT resultsTransfusion reactionsDirect antiglobulin test resultsCell exchangeIncompatible red blood cellsSymptoms of hemolysisRed blood cell unitsPositive antibody screenBlood group antibodiesAntigen-negative unitsAnamnestic increaseAntigen reexposureFurther hemolysisRed blood cellsAntibody screenGroup antibodiesPatient historyBlood cellsDHTRTransfusionHemolysisSymptomsCell unitsThe Development of a Novel Molecular Assay Examining the Role of Aminopeptidase P Polymorphisms in Acute Hypotensive Transfusion Reactions
Hui Y, Wu Y, Tormey CA. The Development of a Novel Molecular Assay Examining the Role of Aminopeptidase P Polymorphisms in Acute Hypotensive Transfusion Reactions. Archives Of Pathology & Laboratory Medicine 2013, 137: 96-9. PMID: 23276181, DOI: 10.5858/arpa.2011-0466-oa.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdolescentAgedAminopeptidasesAngiotensin-Converting Enzyme InhibitorsBase SequenceBradykininCase-Control StudiesDNA PrimersFemaleGenetic Predisposition to DiseaseHeterozygoteHomozygoteHumansHypotensionMaleMiddle AgedPolymerase Chain ReactionPolymorphism, Single NucleotideTransfusion ReactionConceptsAcute hypotensive transfusion reactionsHypotensive transfusion reactionsACE-IsTransfusion reactionsSingle nucleotide polymorphismsMolecular assaysHarmful adverse effectsPolymerase chain reactionBradykinin degradationPatientsEnzyme inhibitorsBradykinin generationAPP geneNovel molecular assayPilot studyAdverse effectsChain reactionFurther studiesAminopeptidase PXPNPEP2PolymorphismAssaysAPP activitySequencing resultsTransfusion
2012
Diagnosis, Treatment, and Reporting of Adverse Effects of Transfusion
Torres R, Kenney B, Tormey C. Diagnosis, Treatment, and Reporting of Adverse Effects of Transfusion. Lab Medicine 2012, 43: 217-231. DOI: 10.1309/lm3naabjjk1hnyfu.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsTransfusion reactionsAdverse transfusion eventsMild transfusion reactionRisk of transfusionPulmonary complicationsTransfusion eventsClinical featuresAnaphylactic reactionsFebrile responseClinical dilemmaTransfusionHemolytic reactionTransfusion medicineAdverse effectsSeptic reactionsDiagnosisCurrent understandingComplicationsEtiologyIncidencePreventionReporting
2009
Estimation of Combat-Related Blood Group Alloimmunization and Delayed Serologic Transfusion Reactions in U.S. Military Veterans
Tormey CA, Stack G. Estimation of Combat-Related Blood Group Alloimmunization and Delayed Serologic Transfusion Reactions in U.S. Military Veterans. Military Medicine 2009, 174: 503-507. PMID: 20731281, DOI: 10.7205/milmed-d-02-5808.Peer-Reviewed Original ResearchConceptsSerologic transfusion reactionsTransfusion reactionsVeterans Affairs Medical CenterAnamnestic immune responseMilitary veteran patientsBlood group alloantibodiesMilitary veteransPre-existing antibodiesU.S. military veteransAlloimmunization ratePrior alloimmunizationVeteran patientsTransfusion recordsVA careImmune responseMedical CenterAlloimmunizationAlloantibodiesVeteransAntibodiesHigh rateTransfusionPatientsPrevalenceCareAnalysis of transfusion reactions associated with prestorage‐pooled platelet components
Tormey CA, Sweeney JD, Champion MH, Pisciotto PT, Snyder EL, Wu Y. Analysis of transfusion reactions associated with prestorage‐pooled platelet components. Transfusion 2009, 49: 1242-1247. PMID: 19389029, DOI: 10.1111/j.1537-2995.2009.02128.x.Peer-Reviewed Original ResearchConceptsRandom donor plateletsSingle-donor plateletsTransfusion reactionsPlatelet infusionTransfusion-related acute lung injuryCommon adverse eventsPLT productsAcute lung injuryTertiary care hospitalCases of sepsisAllergic transfusion reactionsTransfusion reaction ratesSignificant differencesAdverse eventsLung injuryCare hospitalVolume overloadFebrile reactionsChi-square analysisTotal infusionPlatelet componentsInfusionStudy designP-valuePlateletsThe persistence and evanescence of blood group alloantibodies in men
Tormey CA, Stack G. The persistence and evanescence of blood group alloantibodies in men. Transfusion 2009, 49: 505-512. PMID: 19040411, DOI: 10.1111/j.1537-2995.2008.02014.x.Peer-Reviewed Original ResearchConceptsBlood group alloantibodiesVeterans Affairs Medical CenterInitial negative testingTransfusion service recordsTransfusion-related alloimmunizationDuration of followHemolytic transfusion reactionsMonths of detectionFirst antibodyMale patientsTransfusion reactionsMedical CenterAlloantibodiesNegative testingAntibody detectionYear of inductionStudy designAntigenic specificityAntibodiesMilitary veteransPatientsMore yearsTwo-thirdsService recordsMen
2008
Delayed intravascular haemolysis following multiple asymptomatic ABO‐incompatible red blood cell transfusions in a patient with hepatic failure
Tormey CA, Stack G. Delayed intravascular haemolysis following multiple asymptomatic ABO‐incompatible red blood cell transfusions in a patient with hepatic failure. Vox Sanguinis 2008, 95: 232-235. PMID: 19121188, DOI: 10.1111/j.1423-0410.2008.01085.x.Peer-Reviewed Original ResearchConceptsABO-incompatible red blood cell (RBC) transfusionsRed blood cell transfusionBlood cell transfusionFresh frozen plasmaCell transfusionHepatic failureDelayed Haemolytic Transfusion ReactionAnamnestic antibody responseLow complement levelsHaemolytic transfusion reactionsOnset of haemolysisFirst transfusionRBC transfusionComplement levelsIncompatible transfusionsAntibody responseAntibody titresHepatic diseaseTransfusion reactionsIntravascular haemolysisTransfusionPatientsRBC unitsB RBCsHaemolysis