2017
Irradiation of Red Blood Cells and Alloimmunization
Tormey CA, Hendrickson JE. Irradiation of Red Blood Cells and Alloimmunization. Lab Medicine 2017, 48: 172-177. PMID: 28340248, DOI: 10.1093/labmed/lmx018.Peer-Reviewed Original ResearchConceptsAlloimmunization rateRBC alloimmunization rateTime of transfusionRBC unit transfusionPostoperative bleedingRed blood cell damageRed blood cellsRBC transfusionCommon diagnosisImmunosuppressive disordersTransfusion recipientsBlood cell damageAnimal modelsStudy subjectsTransfusionControl groupRBC antigensAntibody screeningRBC unitsPatientsBlood cellsCell damageRBCsOxidative damageDiagnosis
2016
Bridging channel dendritic cells induce immunity to transfused red blood cells
Calabro S, Gallman A, Gowthaman U, Liu D, Chen P, Liu J, Krishnaswamy JK, Nascimento MS, Xu L, Patel SR, Williams A, Tormey CA, Hod EA, Spitalnik SL, Zimring JC, Hendrickson JE, Stowell SR, Eisenbarth SC. Bridging channel dendritic cells induce immunity to transfused red blood cells. Journal Of Experimental Medicine 2016, 213: 887-896. PMID: 27185856, PMCID: PMC4886363, DOI: 10.1084/jem.20151720.Peer-Reviewed Original ResearchConceptsSplenic dendritic cellsDendritic cellsRBC transfusionT cellsImmune responseRed blood cell transfusionBlood cell transfusionT cell primingConventional dendritic cellsDetrimental immune responsesB cell responsesNaive T cellsT cell helpMurine transfusion modelRBC transfusion supportTime of transfusionRBC alloantigensCell transfusionDC subsetsAllogeneic RBCsRed blood cellsRenal failureTransfusion supportMajor complicationsCell priming