2022
Recording of ’COVID-19 vaccine declined‘: a cohort study on 57.9 million National Health Service patients’ records in situ using OpenSAFELY, England, 8 December 2020 to 25 May 2021
Curtis HJ, Inglesby P, MacKenna B, Croker R, Hulme WJ, Rentsch CT, Bhaskaran K, Mathur R, Morton CE, Bacon SC, Smith RM, Evans D, Mehrkar A, Tomlinson L, Walker AJ, Bates C, Hickman G, Ward T, Morley J, Cockburn J, Davy S, Williamson EJ, Eggo RM, Parry J, Hester F, Harper S, O’Hanlon S, Eavis A, Jarvis R, Avramov D, Griffiths P, Fowles A, Parkes N, Evans SJ, Douglas IJ, Smeeth L, Goldacre B. Recording of ’COVID-19 vaccine declined‘: a cohort study on 57.9 million National Health Service patients’ records in situ using OpenSAFELY, England, 8 December 2020 to 25 May 2021. Eurosurveillance 2022, 27: 2100885. PMID: 35983770, PMCID: PMC9389857, DOI: 10.2807/1560-7917.es.2022.27.33.2100885.Peer-Reviewed Original ResearchConceptsCOVID-19 vaccinationCOVID-19 vaccineCohort studyPriority patientsRetrospective cohort studyPrimary care recordsMore deprived areasUnvaccinated patientsSubsequent vaccinationSouth Asian peopleSouth Asian populationGeneral practicePatientsCare recordsClinical record systemsVaccinationNHS EnglandPatient recordsVaccineDeprived areasAsian populationsOpenSAFELYDemographic subgroupsRecord systemDemographic factors
2021
OpenSAFELY NHS Service Restoration Observatory 1: primary care clinical activity in England during the first wave of COVID-19
Curtis HJ, MacKenna B, Croker R, Inglesby P, Walker AJ, Morley J, Mehrkar A, Morton CE, Bacon S, Hickman G, Bates C, Evans D, Ward T, Cockburn J, Davy S, Bhaskaran K, Schultze A, Rentsch CT, Williamson EJ, Hulme WJ, McDonald HI, Tomlinson L, Mathur R, Drysdale H, Eggo RM, Wing K, Wong AY, Forbes H, Parry J, Hester F, Harper S, Evans SJ, Douglas IJ, Smeeth L, Goldacre B, . OpenSAFELY NHS Service Restoration Observatory 1: primary care clinical activity in England during the first wave of COVID-19. British Journal Of General Practice 2021, 72: bjgp.2021.0380. PMID: 34750105, PMCID: PMC8589464, DOI: 10.3399/bjgp.2021.0380.Peer-Reviewed Original ResearchConceptsClinical activityGeneral practicePre-pandemic levelsNormal levelsPrimary care dataHealthcare activitiesAsthma reviewCohort studyRespiratory symptomsRespiratory infectionsDisease reviewDiseases codesRespiratory diseaseLaboratory testsNHS EnglandPatient recordsCare dataSustained dropCOVD-19 pandemicCOVID-19COVID-19 pandemicMost laboratory testsBroader recoverySmall reductionPandemicClinical coding of long COVID in English primary care: a federated analysis of 58 million patient records in situ using OpenSAFELY
Walker AJ, MacKenna B, Inglesby P, Tomlinson L, Rentsch CT, Curtis HJ, Morton CE, Morley J, Mehrkar A, Bacon S, Hickman G, Bates C, Croker R, Evans D, Ward T, Cockburn J, Davy S, Bhaskaran K, Schultze A, Williamson EJ, Hulme WJ, McDonald HI, Mathur R, Eggo RM, Wing K, Wong AY, Forbes H, Tazare J, Parry J, Hester F, Harper S, O’Hanlon S, Eavis A, Jarvis R, Avramov D, Griffiths P, Fowles A, Parkes N, Douglas IJ, Evans SJ, Smeeth L, Goldacre B, . Clinical coding of long COVID in English primary care: a federated analysis of 58 million patient records in situ using OpenSAFELY. British Journal Of General Practice 2021, 71: bjgp.2021.0301. PMID: 34340970, PMCID: PMC8340730, DOI: 10.3399/bjgp.2021.0301.Peer-Reviewed Original ResearchConceptsLong COVIDEnglish primary carePrimary careDiagnostic codesPopulation-based cohort studyAcute COVID-19Different diagnostic thresholdsProportion of peoplePlanning of servicesPersistent symptomsCohort studyGeneral practiceClinicians' understandingDiagnostic thresholdNHS EnglandPatient recordsClinical codesClinical codingCareCOVID-19East of EnglandPatientsDemographic factorsCOVIDWeeks
2020
Factors associated with COVID-19-related death using OpenSAFELY
Williamson EJ, Walker AJ, Bhaskaran K, Bacon S, Bates C, Morton CE, Curtis HJ, Mehrkar A, Evans D, Inglesby P, Cockburn J, McDonald HI, MacKenna B, Tomlinson L, Douglas IJ, Rentsch CT, Mathur R, Wong AYS, Grieve R, Harrison D, Forbes H, Schultze A, Croker R, Parry J, Hester F, Harper S, Perera R, Evans SJW, Smeeth L, Goldacre B. Factors associated with COVID-19-related death using OpenSAFELY. Nature 2020, 584: 430-436. PMID: 32640463, PMCID: PMC7611074, DOI: 10.1038/s41586-020-2521-4.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge DistributionAge FactorsAgedAged, 80 and overAgingAsian PeopleAsthmaBetacoronavirusBlack PeopleCohort StudiesCoronavirus InfectionsCOVID-19Diabetes MellitusFemaleHumansHypertensionMaleMiddle AgedPandemicsPneumonia, ViralProportional Hazards ModelsRisk AssessmentSARS-CoV-2Sex CharacteristicsSmokingState MedicineYoung AdultConceptsCOVID-19-related deathsPrimary care electronic health recordsPrimary care recordsLarge cohort studyCoronavirus disease 2019Electronic health recordsSevere asthmaCohort studyClinical factorsSouth Asian peopleSevere outcomesDisease 2019Medical conditionsHigh riskOpenSAFELYWhite ethnicityCare recordsNHS EnglandPatient recordsPatient dataHealth recordsDeathGreater ageAsian peopleRisk