2024
Externally orienting cues improve cognitive control in OCD
Bednarek L, Glover S, Ma X, Pittenger C, Pushkarskaya H. Externally orienting cues improve cognitive control in OCD. Journal Of Behavior Therapy And Experimental Psychiatry 2024, 84: 101959. PMID: 38531125, PMCID: PMC11192454, DOI: 10.1016/j.jbtep.2024.101959.Peer-Reviewed Original ResearchANT-RObsessive thoughtsWarning cueFlanker taskAlerting benefitsModels of obsessive-compulsive disorderHealthy controlsRevised attention network testObsessive-compulsive disorderAttention Network TestSelf-report measuresConflict costsCognitive controlContamination symptomsIncongruent trialsNeurocognitive tasksExecutive functionAttention taskSymptom severityNetwork TestAssociated with severityDistracted participantsCuesExternally orienting cuesFlanker
2023
Prefrontal allopregnanolone mediates the adverse effects of acute stress in a mouse model of tic pathophysiology
Cadeddu R, Van Zandt M, Santovito L, Odeh K, Anderson C, Flanagan D, Nordkild P, Pinna G, Pittenger C, Bortolato M. Prefrontal allopregnanolone mediates the adverse effects of acute stress in a mouse model of tic pathophysiology. Neuropsychopharmacology 2023, 48: 1288-1299. PMID: 37198434, PMCID: PMC10354086, DOI: 10.1038/s41386-023-01603-6.Peer-Reviewed Original ResearchConceptsEffects of allopregnanoloneTourette syndromeCholinergic interneuronsAcute stressPrefrontal cortexPrepulse inhibitionTic pathophysiologyMouse modelAdverse effectsStriatal cholinergic interneuronsDeficient prepulse inhibitionSeverity of ticsPost-mortem studiesPharmacological antagonismPPI deficitsNeurosteroid allopregnanoloneMale miceAdministration doseAllopregnanoloneAnimal modelsBehavioral pathologySymptom severityAcute stressorYoung adulthoodAP levels
2018
Exploring Retrospective Biases in Obsessive-Compulsive Disorder: an Experience-Sampling Study
MacLaren Kelly J, Kertz S, Simpson R, Bloch M, Pittenger C. Exploring Retrospective Biases in Obsessive-Compulsive Disorder: an Experience-Sampling Study. Journal Of Technology In Behavioral Science 2018, 4: 297-302. DOI: 10.1007/s41347-018-0078-y.Peer-Reviewed Original ResearchObsessive-compulsive disorderExperience-sampling methodRecall biasesRetrospective ratingsExperience Sampling StudyParticipants' retrospective ratingsSymptom severityOCD symptom severityYale-Brown Obsessive Compulsive ScalePotential recall biasesObsessive Compulsive ScaleRetrospective biasesCompulsive disorderSymptom changeCompulsive ScaleRetrospective reportsCurrent studyBiasesDistressRecall biasRetrospective estimatesProgress monitoringFuture directionsRatingsSymptom assessment