Induction of the activating transcription factor-4 in the intratumoral CD8+ T cells sustains their viability and anti-tumor activities
Lu Z, Bae E, Verginadis I, Zhang H, Cho C, McBrearty N, George S, Diehl J, Koumenis C, Bradley L, Fuchs S. Induction of the activating transcription factor-4 in the intratumoral CD8+ T cells sustains their viability and anti-tumor activities. Cancer Immunology, Immunotherapy 2022, 72: 815-826. PMID: 36063172, PMCID: PMC10317204, DOI: 10.1007/s00262-022-03286-2.Peer-Reviewed Original ResearchConceptsActivity of CD8Tumor-derived factorsT cellsTumor microenvironmentTranscription factor 4Anti-tumor immunityImmune suppressive factorsFactor 4Anti-tumor activityFunction of ATF4Anti-cancer therapyIntratumoral CD8Cytotoxic CD8Immune therapyTherapeutic regimensAntigenic stimulationCD8Suppressive factorsT lymphocytesMouse modelImpaired activationWild-type counterpartsSelective ablationTherapyInduction of ATF4Ablation of T cell-associated PD-1H enhances functionality and promotes adoptive immunotherapy
Hu L, Chen L, Xiao Z, Zheng X, Chen Y, Xian N, Cho C, Luo L, Huang G, Chen L. Ablation of T cell-associated PD-1H enhances functionality and promotes adoptive immunotherapy. JCI Insight 2022, 7: e148247. PMID: 34905507, PMCID: PMC8855794, DOI: 10.1172/jci.insight.148247.Peer-Reviewed Original ResearchConceptsPD-1HT cellsAdoptive immunotherapyT cell-mediated immune responsesT-cell adoptive immunotherapyAdoptive T-cell therapyCell-mediated immune responsesTumor-infiltrating CD8Antitumor activityT-cell therapySyngeneic mouse tumorsCAR T cellsDeath-1 homologExperimental tumor modelsAdoptive transferActivated CD8Coinhibitory moleculesCytokine productionDeficient miceImmune responseHuman xenograftsCD8Tumor microenvironmentTumor modelMouse tumors