The Fibronectin III‐1 Domain Activates a PI3‐Kinase/Akt Signaling Pathway Leading to αvβ5 Integrin Activation and TRAIL Resistance in Human Lung Cancer Cells
Cho C, McKeown‐Longo P. The Fibronectin III‐1 Domain Activates a PI3‐Kinase/Akt Signaling Pathway Leading to αvβ5 Integrin Activation and TRAIL Resistance in Human Lung Cancer Cells. The FASEB Journal 2016, 30: lb82-lb82. DOI: 10.1096/fasebj.30.1_supplement.lb82.Peer-Reviewed Original ResearchLung cancer cellsTRAIL resistanceNon-small cell lung cancerH460 lung cancer cellsCancer cellsCell lung cancerHuman lung cancer cellsLung cancer resistancePI3K/Akt pathwayTumor-stroma interfaceCancer cell resistanceAkt Signaling PathwayΑvβ5 integrin receptorLung cancerImmunohistochemical stainingTumor stromaFirst Type III domainFnIII-1cDrug resistanceBlood vesselsAkt pathwayCancer resistanceSignaling pathwaysFibronectin contributesSubsequent apoptosis