The effects of age on rabbit MCL fibroblast matrix synthesis in response to TGF-β1 or EGF
Deie M, Marui T, Allen C, Hildebrand K, Georgescu H, Niyibizi C, Woo S. The effects of age on rabbit MCL fibroblast matrix synthesis in response to TGF-β1 or EGF. Mechanisms Of Ageing And Development 1997, 97: 121-130. PMID: 9226631, DOI: 10.1016/s0047-6374(97)00049-3.Peer-Reviewed Original ResearchConceptsMedial collateral ligamentEffect of ageEpidermal growth factorTotal protein synthesisMCL fibroblastsGrowth factorImmature rabbitsProtein synthesisSenescent groupCollateral ligamentTGF-β1Baseline levelsOwn controlDifferent dosesLigament fibroblastsLess collagenCollagen synthesisEGF doseRabbitsAgeSignificant reductionDoseDosesMatrix synthesisFibroblasts