Gender-related neuroanatomical differences in alcohol dependence: findings from the ENIGMA Addiction Working Group
Rossetti MG, Patalay P, Mackey S, Allen NB, Batalla A, Bellani M, Chye Y, Cousijn J, Goudriaan AE, Hester R, Hutchison K, Li CR, Martin-Santos R, Momenan R, Sinha R, Schmaal L, Sjoerds Z, Solowij N, Suo C, van Holst RJ, Veltman DJ, Yücel M, Thompson PM, Conrod P, Garavan H, Brambilla P, Lorenzetti V. Gender-related neuroanatomical differences in alcohol dependence: findings from the ENIGMA Addiction Working Group. NeuroImage Clinical 2021, 30: 102636. PMID: 33857771, PMCID: PMC8065340, DOI: 10.1016/j.nicl.2021.102636.Peer-Reviewed Original ResearchMeSH KeywordsAlcoholismBrainFemaleGray MatterHumansMagnetic Resonance ImagingMaleNeuroanatomySex FactorsConceptsENIGMA Addiction Working GroupAlcohol dependenceNeuroanatomical differencesAlcohol-dependent menSmaller amygdala volumesGlobal brain measuresGender-related differencesClinical outcomesControl menCorpus callosumAmygdala volumeNeurobiological effectsGM volumeGender differencesSmaller amygdalaStandard drinksBrain regionsIntracranial volumeWorking GroupTotal GMBrain measuresCerebellar GMNeurobiological substratesWomenEducation yearsSex differences in the neuroanatomy of alcohol dependence: hippocampus and amygdala subregions in a sample of 966 people from the ENIGMA Addiction Working Group
Grace S, Rossetti MG, Allen N, Batalla A, Bellani M, Brambilla P, Chye Y, Cousijn J, Goudriaan AE, Hester R, Hutchison K, Labuschagne I, Momenan R, Martin-Santos R, Rendell P, Solowij N, Sinha R, Li CR, Schmaal L, Sjoerds Z, Suo C, Terrett G, van Holst RJ, Veltman DJ, Yücel M, Thompson P, Conrod P, Mackey S, Garavan H, Lorenzetti V. Sex differences in the neuroanatomy of alcohol dependence: hippocampus and amygdala subregions in a sample of 966 people from the ENIGMA Addiction Working Group. Translational Psychiatry 2021, 11: 156. PMID: 33664226, PMCID: PMC7933136, DOI: 10.1038/s41398-021-01204-1.Peer-Reviewed Original ResearchMeSH KeywordsAlcoholismAmygdalaFemaleHippocampusHumansMagnetic Resonance ImagingMaleNeuroanatomySex CharacteristicsConceptsENIGMA Addiction Working GroupAlcohol dependenceAmygdala subregionsAlcohol-dependent malesUnderlying neurobiological mechanismsSex differencesSubfield volumesTotal amygdalaAlcohol doseBasolateral nucleusAnimal modelsMale controlsWorking GroupAmygdalar subregionsMental healthNeurobiological mechanismsComparison groupCognitive problemsHippocampusMalesFemalesDistinct mechanismsLittle evidenceGroupAmygdala