2023
Relationships of in vivo brain norepinephrine transporter and age, BMI, and gender
Koohsari S, Sadabad F, Pittman B, Gallezot J, Carson R, van Dyck C, Li C, Potenza M, Matuskey D. Relationships of in vivo brain norepinephrine transporter and age, BMI, and gender. Synapse 2023, 77: e22279. PMID: 37382240, PMCID: PMC10416616, DOI: 10.1002/syn.22279.Peer-Reviewed Original ResearchConceptsBody mass indexMultilinear reference tissue model 2Gender-related differencesBrain norepinephrine transportersNorepinephrine transporterAge-related declineStructural MR scansBrain regionsReference tissue model 2Mass indexRaphe nucleusLocus coeruleusOccipital cortexBMI relationshipHealthy adultsHigh-resolution research tomographAvailable radiotracersHealthy participantsMR scansAgeAnatomic templateReference regionNegative associationNet availabilityPotential age
2019
The interrelationship of body mass index with gray matter volume and resting-state functional connectivity of the hypothalamus
Le TM, Liao DL, Ide J, Zhang S, Zhornitsky S, Wang W, Li CR. The interrelationship of body mass index with gray matter volume and resting-state functional connectivity of the hypothalamus. International Journal Of Obesity 2019, 44: 1097-1107. PMID: 31796869, PMCID: PMC8643195, DOI: 10.1038/s41366-019-0496-8.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBody Mass IndexBody WeightFemaleGray MatterHumansHypothalamusMagnetic Resonance ImagingMaleNerve NetYoung AdultConceptsResting-state functional connectivityWhole-brain multiple regressionGray matter volumeInsula connectivityBody mass indexFunctional connectivitySeed-based resting-state functional connectivityMatter volumeSuperior parietal lobuleVoxel-based morphometry analysisMultiple regressionConclusionsThe current findingsBody weightCognitive controlMultiple brain circuitsBrain mechanismsIndividual differencesInhibitory controlParietal lobuleHypothalamic connectivityMass indexMediation analysisBrain circuitsHigher body mass indexCurrent findings