2021
Gender-related neuroanatomical differences in alcohol dependence: findings from the ENIGMA Addiction Working Group
Rossetti MG, Patalay P, Mackey S, Allen NB, Batalla A, Bellani M, Chye Y, Cousijn J, Goudriaan AE, Hester R, Hutchison K, Li CR, Martin-Santos R, Momenan R, Sinha R, Schmaal L, Sjoerds Z, Solowij N, Suo C, van Holst RJ, Veltman DJ, Yücel M, Thompson PM, Conrod P, Garavan H, Brambilla P, Lorenzetti V. Gender-related neuroanatomical differences in alcohol dependence: findings from the ENIGMA Addiction Working Group. NeuroImage Clinical 2021, 30: 102636. PMID: 33857771, PMCID: PMC8065340, DOI: 10.1016/j.nicl.2021.102636.Peer-Reviewed Original ResearchConceptsENIGMA Addiction Working GroupAlcohol dependenceNeuroanatomical differencesAlcohol-dependent menSmaller amygdala volumesGlobal brain measuresGender-related differencesClinical outcomesControl menCorpus callosumAmygdala volumeNeurobiological effectsGM volumeGender differencesSmaller amygdalaStandard drinksBrain regionsIntracranial volumeWorking GroupTotal GMBrain measuresCerebellar GMNeurobiological substratesWomenEducation yearsSex differences in neural responses to reward and the influences of individual reward and punishment sensitivity
Dhingra I, Zhang S, Zhornitsky S, Wang W, Le TM, Li CR. Sex differences in neural responses to reward and the influences of individual reward and punishment sensitivity. BMC Neuroscience 2021, 22: 12. PMID: 33639845, PMCID: PMC7913329, DOI: 10.1186/s12868-021-00618-3.Peer-Reviewed Original ResearchConceptsMonetary incentive delay taskFunctional magnetic resonance imagingNeural responsesSex differencesReward-related brain activationBilateral orbitofrontal cortexMagnetic resonance imagingIncentive delay taskWhole-brain regressionVisual cortexResonance imagingOrbitofrontal cortexBrain activationWomenSuccess rateFMRI studyMenDelay taskImaging literatureNeural sensitivityCortexNeural basisAffective functionsHigher SR scoresLarge wins
2019
Cue-elicited craving, thalamic activity, and physiological arousal in adult non-dependent drinkers
Wang W, Zhornitsky S, Le TM, Dhingra I, Zhang S, Krystal JH, Li CR. Cue-elicited craving, thalamic activity, and physiological arousal in adult non-dependent drinkers. Journal Of Psychiatric Research 2019, 116: 74-82. PMID: 31202048, PMCID: PMC6606341, DOI: 10.1016/j.jpsychires.2019.06.005.Peer-Reviewed Original ResearchConceptsSkin conductance responsesPhysiological arousalThalamic activityNeural processesNeutral cue exposureMediation analysisHigher skin conductance responsesCue exposure paradigmCue-related activationsCue-elicited cravingCue-elicited drugNon-dependent drinkersImportant sex differencesSkin conductance dataPharmacological therapyAlcohol drinkersNeural targetsAlcohol cravingExposure paradigmCue exposureNeural correlatesNeural basisConductance responsesWomenCue activity
2009
Gender Differences in Cognitive Control: an Extended Investigation of the Stop Signal Task
Li CS, Zhang S, Duann JR, Yan P, Sinha R, Mazure CM. Gender Differences in Cognitive Control: an Extended Investigation of the Stop Signal Task. Brain Imaging And Behavior 2009, 3: 262-276. PMID: 19701485, PMCID: PMC2728908, DOI: 10.1007/s11682-009-9068-1.Peer-Reviewed Original ResearchRegional brain activationTrial reaction timeStop-signal taskCognitive controlBrain activationGo-trial reaction timesRight inferior parietal lobuleGender differencesReaction timeSub-cortical areasInferior parietal lobuleFunctional magnetic resonancePost-SEClinical conditionsControl disordersCortical activationClinical implicationsParietal lobuleInitiate studiesResponse inhibitionNeural processesSignal taskGreater activationWomenMen
2006
Gender differences in the neural correlates of response inhibition during a stop signal task
Li CS, Huang C, Constable RT, Sinha R. Gender differences in the neural correlates of response inhibition during a stop signal task. NeuroImage 2006, 32: 1918-1929. PMID: 16806976, DOI: 10.1016/j.neuroimage.2006.05.017.Peer-Reviewed Original ResearchConceptsStop-signal taskBrain activationResponse inhibitionGreater activationSignal taskAnterior cingulate cortexRegional brain activationNeural correlatesCognitive-motor tasksGender differencesFunctional magnetic resonanceStop-signal inhibitionMotor thalamusGlobus pallidusSubcortical areasYears of educationMotor circuitryCingulate cortexBrain regionsCaudate tailMotor tasksWomenSuccess rateLower statistical thresholdMen