2018
Noradrenergic Dysfunction in Alzheimer's and Parkinson's Diseases—An Overview of Imaging Studies
Peterson AC, Li CR. Noradrenergic Dysfunction in Alzheimer's and Parkinson's Diseases—An Overview of Imaging Studies. Frontiers In Aging Neuroscience 2018, 10: 127. PMID: 29765316, PMCID: PMC5938376, DOI: 10.3389/fnagi.2018.00127.Peer-Reviewed Original ResearchNoradrenergic dysfunctionParkinson's diseaseAlzheimer's diseaseDefault mode networkMRI studiesImaging studiesPathogenesis of ADPostmortem anatomical studiesConventional therapeutic strategiesControl network activityStructural MRI studiesMagnetic resonance imagingFunctional MRI studyHuman imaging studiesLC degenerationCerebral cortexNoradrenergic projectionsDopaminergic neurotransmissionNoradrenergic systemTherapeutic strategiesMedication developmentFunctional alterationsCognitive declineCognitive impairmentDysfunction
2017
Proactive Control: Neural Oscillatory Correlates of Conflict Anticipation and Response Slowing
Chang A, Ide JS, Li HH, Chen CC, Li CR. Proactive Control: Neural Oscillatory Correlates of Conflict Anticipation and Response Slowing. ENeuro 2017, 4: eneuro.0061-17.2017. PMID: 28560315, PMCID: PMC5446487, DOI: 10.1523/eneuro.0061-17.2017.Peer-Reviewed Original ResearchConceptsStop-signal taskProactive controlConflict anticipationReaction timeTrial behavioral adjustmentsPrevious functional MRI studiesNeural oscillatory correlatesFunctional MRI studyDelta-theta bandLower theta bandDifferent behavioral paradigmsOscillatory correlatesNeural processesLow beta bandResponse slowingBehavioral adjustmentBehavioral paradigmsFunctional MRITime-frequency activityBehavioral strategiesElectrophysiological studiesElectrophysiological substrateMRI studiesBrain regionsRT clusters
2010
Biological markers of the effects of intravenous methylphenidate on improving inhibitory control in cocaine-dependent patients
Li CS, Morgan PT, Matuskey D, Abdelghany O, Luo X, Chang JL, Rounsaville BJ, Ding YS, Malison RT. Biological markers of the effects of intravenous methylphenidate on improving inhibitory control in cocaine-dependent patients. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 14455-14459. PMID: 20660731, PMCID: PMC2922598, DOI: 10.1073/pnas.1002467107.Peer-Reviewed Original ResearchConceptsMiddle frontal cortexStop-signal reaction timeCocaine-dependent patientsWhole-brain linear regressionLonger stop-signal reaction timesFunctional MRI studyInhibitory controlInhibition-related activationBlood pressureIntravenous methylphenidatePeripheral biomarkersSignal reaction timeFrontal cortexStop-signal taskIndividualized treatmentHealthy individualsMRI studiesVentromedial prefrontal cortexSpecific neural mechanismsCocaine dependenceBiological markersPrefrontal cortexPatientsMethylphenidate responseSignal task