2023
Relationships of in vivo brain norepinephrine transporter and age, BMI, and gender
Koohsari S, Sadabad F, Pittman B, Gallezot J, Carson R, van Dyck C, Li C, Potenza M, Matuskey D. Relationships of in vivo brain norepinephrine transporter and age, BMI, and gender. Synapse 2023, 77: e22279. PMID: 37382240, PMCID: PMC10416616, DOI: 10.1002/syn.22279.Peer-Reviewed Original ResearchConceptsBody mass indexMultilinear reference tissue model 2Gender-related differencesBrain norepinephrine transportersNorepinephrine transporterAge-related declineStructural MR scansBrain regionsReference tissue model 2Mass indexRaphe nucleusLocus coeruleusOccipital cortexBMI relationshipHealthy adultsHigh-resolution research tomographAvailable radiotracersHealthy participantsMR scansAgeAnatomic templateReference regionNegative associationNet availabilityPotential age
2019
Imaging the effects of age on proactive control in healthy adults
Hu S, Job M, Jenks SK, Chao HH, Li CR. Imaging the effects of age on proactive control in healthy adults. Brain Imaging And Behavior 2019, 13: 1526-1537. PMID: 31011949, PMCID: PMC6812594, DOI: 10.1007/s11682-019-00103-w.Peer-Reviewed Original ResearchConceptsInferior occipital gyrusStop-signal reaction timePrefrontal cortexProactive controlProactive inhibitionOlder adultsReactive inhibitionSuperior parietal lobuleSequential effectsEffect of ageSignal reaction timeCaudate headDistinct neural processesParacentral lobuleTrial reaction timeVentromedial prefrontal cortexLateral prefrontal cortexHealthy adultsNeural changesNeural plasticityOccipital gyrusParietal lobuleReaction timeYoung adultsBelief ModelCerebral responses to self-initiated action during social interactions
Wang W, Zhornitsky S, Li C, Zhang S, Ide JS, Joormann J, Li CR. Cerebral responses to self-initiated action during social interactions. Cognitive, Affective, & Behavioral Neuroscience 2019, 19: 1521-1535. PMID: 30941709, PMCID: PMC6774916, DOI: 10.3758/s13415-019-00711-5.Peer-Reviewed Original ResearchConceptsSelf-initiated actionsSocial interactionSocial communication needsSocial behavioral disordersPosterior cortical activationSocial exclusionHealthy adultsMind processingCyberball gameSocial anxietySocial emotionsNeural correlatesPercentage of trialsSubjective awarenessAngular gyrusNeural markersCortical activationCortical activityBall tossBehavioral disordersCerebral responsesFuture researchCommunication needsExtant studiesOwn volition
2017
Barratt Impulsivity in Healthy Adults Is Associated with Higher Gray Matter Concentration in the Parietal Occipital Cortex that Represents Peripheral Visual Field
Ide JS, Tung HC, Yang CT, Tseng YC, Li CR. Barratt Impulsivity in Healthy Adults Is Associated with Higher Gray Matter Concentration in the Parietal Occipital Cortex that Represents Peripheral Visual Field. Frontiers In Human Neuroscience 2017, 11: 222. PMID: 28522966, PMCID: PMC5415556, DOI: 10.3389/fnhum.2017.00222.Peer-Reviewed Original ResearchGray matter volumeGray matter concentrationPeripheral visual fieldOccipital cortexBarratt impulsivityVisual fieldYoung adultsPrefrontal cortical areasParietal-occipital cortexHigher impulsivity scoresMotor subscoresCortical volumeCortical areasMatter volumeCerebral structuresHealthy adultsClinical importanceHealthy populationNeuropsychiatric conditionsFrontal dysfunctionAlcohol useImpulsive individualsAdultsImpulsivity scoresNeural correlates
2016
Methylphenidate Modulates Functional Network Connectivity to Enhance Attention
Rosenberg MD, Zhang S, Hsu WT, Scheinost D, Finn ES, Shen X, Constable RT, Li CS, Chun MM. Methylphenidate Modulates Functional Network Connectivity to Enhance Attention. Journal Of Neuroscience 2016, 36: 9547-9557. PMID: 27629707, PMCID: PMC5039242, DOI: 10.1523/jneurosci.1746-16.2016.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderSustained attentionWhole-brain connectivity patternsFunctional brain networksHyperactivity disorderBrain networksConnectivity patternsConnectome-based predictive modeling approachWhole-brain functional connectivity patternsWhole-brain functional connectivity networksSustained attention taskStop-signal taskDose of methylphenidateFunctional network connectivityCausal roleFunctional connectivity patternsHealthy adultsAttention taskCognitive abilitiesPromising neuromarkerNetwork strengthBehavioral predictionsADHD treatmentConnectivity signaturesFunctional connectivity networksThe Effects of Methylphenidate on Resting-State Functional Connectivity of the Basal Nucleus of Meynert, Locus Coeruleus, and Ventral Tegmental Area in Healthy Adults
Kline RL, Zhang S, Farr OM, Hu S, Zaborszky L, Samanez-Larkin GR, Li CS. The Effects of Methylphenidate on Resting-State Functional Connectivity of the Basal Nucleus of Meynert, Locus Coeruleus, and Ventral Tegmental Area in Healthy Adults. Frontiers In Human Neuroscience 2016, 10: 149. PMID: 27148006, PMCID: PMC4834346, DOI: 10.3389/fnhum.2016.00149.Peer-Reviewed Original ResearchResting-state functional connectivityEffects of methylphenidateAttention deficit hyperactivity disorderLocus coeruleusPositive connectivityNegative connectivityFunctional connectivityBrain resting-state functional connectivityHealthy adultsDeficit hyperactivity disorderBasal nucleusDose of methylphenidateMiddle occipital gyrusSeed regionVTA/SNcVentral tegmental area/substantia nigraCognitive controlVentral tegmental areaHyperactivity disorderOccipital gyrusT-testCatecholaminergic signalingTwo-sample t-testMethylphenidatePrecentral gyrus
2015
Resting-State Functional Connectivity of the Locus Coeruleus in Humans: In Comparison with the Ventral Tegmental Area/Substantia Nigra Pars Compacta and the Effects of Age
Zhang S, Hu S, Chao HH, Li CR. Resting-State Functional Connectivity of the Locus Coeruleus in Humans: In Comparison with the Ventral Tegmental Area/Substantia Nigra Pars Compacta and the Effects of Age. Cerebral Cortex 2015, 26: 3413-3427. PMID: 26223261, PMCID: PMC4961017, DOI: 10.1093/cercor/bhv172.Peer-Reviewed Original ResearchConceptsVentral tegmental area/substantia nigra pars compactaSubstantia nigra pars compactaLocus coeruleusPars compactaFunctional connectivityResting-state functional connectivityCerebral functional connectivityNumerous animal studiesFronto-parietal cortexRight anterior insulaResting-state fMRI dataEffect of ageCerebral cortexNoradrenergic inputCognitive motor controlAnimal studiesCortex decreasesHealthy adultsCerebellum increasesMidbrain nucleiBilateral amygdalaMidbrain structuresAnterior insulaCognitive manifestationsMotor control
2014
The effects of methylphenidate on resting-state striatal, thalamic and global functional connectivity in healthy adults
Farr OM, Zhang S, Hu S, Matuskey D, Abdelghany O, Malison RT, Li CS. The effects of methylphenidate on resting-state striatal, thalamic and global functional connectivity in healthy adults. The International Journal Of Neuropsychopharmacology 2014, 17: 1177-1191. PMID: 24825078, PMCID: PMC4506752, DOI: 10.1017/s1461145714000674.Peer-Reviewed Original ResearchConceptsEffects of methylphenidateResting-state connectivityFunctional connectivityResting-state functional connectivityFrontal executive areasRegional brain activationAmygdala/hippocampusPrefrontal cortical connectivityDorsal striatumHealthy adultsCognitive performanceBrain activationExecutive areasGlobal functional connectivityCatecholaminergic signalingMotor cortexBrain regionsBrain functionPrimary motor cortexCortical connectivityCerebral connectivityMemory circuitsCatecholaminergic dysfunctionMethylphenidatePsychiatric disordersThe Effects of Methylphenidate on Cerebral Activations to Salient Stimuli in Healthy Adults
Farr OM, Hu S, Matuskey D, Zhang S, Abdelghany O, Li CS. The Effects of Methylphenidate on Cerebral Activations to Salient Stimuli in Healthy Adults. Experimental And Clinical Psychopharmacology 2014, 22: 154-165. PMID: 24188171, PMCID: PMC4105943, DOI: 10.1037/a0034465.Peer-Reviewed Original ResearchConceptsStop-signal taskSalient stimuliSaliency processingFunctional MRIAttention deficit hyperactivity disorderRight inferior parietal cortexHigh motivational valueDeficit hyperactivity disorderEffects of methylphenidateInferior parietal cortexHealthy adultsNeural basisCognitive functioningMotivational valueAttention disordersHyperactivity disorderBilateral caudate headCatecholaminergic signalingMethylphenidate groupParietal cortexCerebral activationHigher activationCatecholaminergic treatmentPrimary motor cortexCerebral activity
2013
Ventromedial prefrontal cortex and the regulation of physiological arousal
Zhang S, Hu S, Chao HH, Ide JS, Luo X, Farr OM, Li CS. Ventromedial prefrontal cortex and the regulation of physiological arousal. Social Cognitive And Affective Neuroscience 2013, 9: 900-908. PMID: 23620600, PMCID: PMC4090954, DOI: 10.1093/scan/nst064.Peer-Reviewed Original ResearchConceptsSkin conductance levelVentromedial prefrontal cortexPrefrontal cortexDorsal anterior cingulate cortexCausal roleAnterior cingulate cortexFunctional magnetic resonance imagingMagnetic resonance imagingCerebral blood oxygenationSkin conductance measurementsHealthy adultsPhysiological arousalUnderstanding of dysfunctionCingulate cortexResonance imagingBrain regionsBlood oxygenationAnxiety disordersAltered controlCortexGranger causality analysisSkin conductance responsesBehavioral tasksPhasic skin conductance responsesSkin conductance
2012
The effects of age on cerebral activations: internally versus externally driven processes
Hu S, Chao H, Winkler AD, Li CS. The effects of age on cerebral activations: internally versus externally driven processes. Frontiers In Aging Neuroscience 2012, 4: 4. PMID: 22536185, PMCID: PMC3334814, DOI: 10.3389/fnagi.2012.00004.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingCerebral activationRegional brain activationAge-related decreaseCognitive processesPrepotent responsesPsychological constructsCognitive functioningSignal taskBrain activationGo trialsFMRI dataGo signalSE trialsEffect of ageImaging literatureYoung adultsStop signalHealthy adultsInfluence of ageSeeming inconsistencyAdultsMagnetic resonance imagingYears of ageFunctioning
2011
Neural processes of preparatory control for stop signal inhibition
Hu S, Li C. Neural processes of preparatory control for stop signal inhibition. Human Brain Mapping 2011, 33: 2785-2796. PMID: 21976392, PMCID: PMC3293936, DOI: 10.1002/hbm.21399.Peer-Reviewed Original ResearchConceptsStop-signal reaction timeFunctional magnetic resonance imagingMotor inhibitionShorter stop-signal reaction timesPrefrontal cortexRight orbital frontal cortexMotor executionPrimary motor cortexOrbital frontal cortexSignal inhibitionMagnetic resonance imagingPosterior cingulate cortexInferior parietal lobuleRight prefrontal cortexMotor cortexSignal reaction timeBilateral putamenFrontal cortexHealthy adultsVentromedial prefrontal cortexCingulate cortexResonance imagingPreparatory inhibitionParietal lobuleStop-signal trials
2010
Dissociable Processes of Cognitive Control during Error and Non-Error Conflicts: A Study of the Stop Signal Task
Hendrick OM, Ide JS, Luo X, Li CS. Dissociable Processes of Cognitive Control during Error and Non-Error Conflicts: A Study of the Stop Signal Task. PLOS ONE 2010, 5: e13155. PMID: 20949134, PMCID: PMC2950843, DOI: 10.1371/journal.pone.0013155.Peer-Reviewed Original Research