2023
Inflammatory disequilibrium and lateral ventricular enlargement in treatment-resistant schizophrenia
Chen W, Gou M, Wang L, Li N, Li W, Tong J, Zhou Y, Xie T, Yu T, Feng W, Li Y, Chen S, Tian B, Tan S, Wang Z, Pan S, Luo X, Zhang P, Huang J, Tian L, Li C, Tan Y. Inflammatory disequilibrium and lateral ventricular enlargement in treatment-resistant schizophrenia. European Neuropsychopharmacology 2023, 72: 18-29. PMID: 37058967, DOI: 10.1016/j.euroneuro.2023.03.014.Peer-Reviewed Original ResearchConceptsAnti-inflammatory cytokinesInflammatory disequilibriumImmune-inflammatory response systemPlasma cytokine levelsTreatment-resistant schizophreniaLateral ventricular enlargementLarger lateral ventricle volumesPro-inflammatory cytokinesLateral ventricle volumeNegative Syndrome ScalePotential pathophysiological processesEnzyme-linked immunosorbentHigher PANSS scoresImmune imbalanceCytokine levelsT helperInflammatory imbalanceImmune biomarkersVentricular enlargementClinical manifestationsRegulatory cytokinesHealthy controlsPANSS scoresTh-17Subcortical volumes
2022
Subcortical structures associated with childhood trauma and perceived stress in schizophrenia
Fan F, Tan S, Liu S, Chen S, Huang J, Wang Z, Yang F, Li CR, Tan Y. Subcortical structures associated with childhood trauma and perceived stress in schizophrenia. Psychological Medicine 2022, 53: 5654-5662. PMID: 36154670, DOI: 10.1017/s0033291722002860.Peer-Reviewed Original ResearchConceptsGray matter volumeAmygdala gray matter volumeSubcortical gray matter volumesClinical symptomsEarly life traumaChildhood traumaSubcortical structuresCortical gray matter volumePerceived stressTotal cortical gray matter volumeAge-matched controlsSmaller amygdala volumesStructural brain imagingClinical featuresClinical manifestationsTrauma ScoreHealthy controlsChildhood trauma scoresLong-term effectsAmygdala volumePatientsMatter volumeEarly childhood traumaSmaller amygdalaVolumetric correlates
2015
Altered resting‐state functional connectivity of the insula in young adults with Internet gaming disorder
Zhang JT, Yao YW, Li CS, Zang YF, Shen ZJ, Liu L, Wang LJ, Liu B, Fang XY. Altered resting‐state functional connectivity of the insula in young adults with Internet gaming disorder. Addiction Biology 2015, 21: 743-751. PMID: 25899520, PMCID: PMC4615265, DOI: 10.1111/adb.12247.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityHealthy control subjectsSuperior temporal gyrusAnterior cingulate cortexPosterior insulaAnterior insulaStronger resting-state functional connectivityGender-matched healthy control subjectsMagnetic resonance imaging studyInternet gaming disorderAngular gyrusSupplemental motor areaResonance imaging studyFunctional magnetic resonance imaging studyClinical manifestationsControl subjectsFunctional abnormalitiesPostcentral gyrusMotor areaPrecentral gyrusCingulate cortexImaging studiesIGD subjectsTemporal gyrusCore symptoms