2024
Progressive alterations of resting-state hypothalamic dysconnectivity in schizophrenia
Li X, Zeng J, Liu N, Yang C, Tao B, Sun H, Gong Q, Zhang W, Li C, Lui S. Progressive alterations of resting-state hypothalamic dysconnectivity in schizophrenia. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2024, 135: 111127. PMID: 39181307, DOI: 10.1016/j.pnpbp.2024.111127.Peer-Reviewed Original ResearchHypothalamic functional connectivityBilateral anterior cingulate cortexAnterior cingulate cortexFunctional connectivityFES patientsCingulate cortexFC decreaseRight thalamusChronically treated schizophrenia patientsHealthy controlsSeed-based functional connectivityFirst-episode patientsPathogenesis of schizophreniaNature of schizophreniaAge-related declineAntipsychotic treatmentAntipsychotic medicationRight caudateLeft putamenIllness durationAnalysis of covarianceSchizophreniaDiagnostic groupsHC groupHypothalamus dysfunctionGray matter volumetric correlates of the polygenic risk of depression: A study of the Human Connectome Project data
Fu X, Chen Y, Luo X, Ide J, Li C. Gray matter volumetric correlates of the polygenic risk of depression: A study of the Human Connectome Project data. European Neuropsychopharmacology 2024, 87: 2-12. PMID: 38936229, DOI: 10.1016/j.euroneuro.2024.06.004.Peer-Reviewed Original ResearchGray matter volumeRegional gray matter volumeGenetic risk of depressionPhenotype of depressionPolygenic risk scoresVoxel-based morphometryRisk of depressionAchenbach Adult Self-ReportRight cerebellum crus ICerebellar gray matter volumeAnterior cingulate volumesPathophysiology of depressionAnterior cingulate cortexCerebellum crus IDSM-oriented scalesMarkers of depressionLeft postcentral gyrusAdult Self-ReportRight gyrus rectusGenetic riskNeural endophenotypesHuman Connectome Project dataDrinking severityHuman Connectome ProjectCingulate volumesThe Neural Correlates of Individual Differences in Reinforcement Learning during Pain Avoidance and Reward Seeking
Le T, Oba T, Couch L, McInerney L, Li C. The Neural Correlates of Individual Differences in Reinforcement Learning during Pain Avoidance and Reward Seeking. ENeuro 2024, 11: eneuro.0437-23.2024. PMID: 38365840, PMCID: PMC10901196, DOI: 10.1523/eneuro.0437-23.2024.Peer-Reviewed Original ResearchConceptsSuperior frontal gyrusReward-seekingCingulate cortexNeural correlatesPain avoidanceAction biasDorsal anterior cingulate cortexLeft posterior cingulate cortexAction-outcome associationsGo/No-Go taskAnterior cingulate cortexPosterior cingulate cortexImpact of outcomesHigher learning rateReward trialsFrontal gyrusAvoidance learningMidcingulate cortexNeural substratesAssociative learningAction tendenciesPre-SMAAssociated with activationPrecentral gyrusPostcentral gyrus
2023
Age-related reduction in trait anxiety: Behavioral and neural evidence of automaticity in negative facial emotion processing
Chaudhary S, Zhang S, Zhornitsky S, Chen Y, Chao H, Li C. Age-related reduction in trait anxiety: Behavioral and neural evidence of automaticity in negative facial emotion processing. NeuroImage 2023, 276: 120207. PMID: 37263454, PMCID: PMC10330646, DOI: 10.1016/j.neuroimage.2023.120207.Peer-Reviewed Original ResearchConceptsFaster reaction timesNegative emotionsAge-related declineEmotional stimuliTrait anxietyAge-related reductionReaction timeEmotion regulation literatureSalient emotional stimuliPositive emotional stimuliFacial emotion processingPrefrontal cortical responsesRostral anterior cingulate cortexWhole-brain regressionAnterior cingulate activityDefault mode networkAnterior cingulate cortexEmotion regulationNeural evidenceEmotion processingDorsolateral PFCStimulus registrationDiminished anxietyPsychophysiological interactionEmotional circuitsThe effects of age on the severity of problem drinking: Mediating effects of positive alcohol expectancy and neural correlates
Chaudhary S, Chen Y, Zhornitsky S, Le T, Zhang S, Chao H, Dominguez J, Li C. The effects of age on the severity of problem drinking: Mediating effects of positive alcohol expectancy and neural correlates. Addiction Biology 2023, 28: e13278. PMID: 37252876, DOI: 10.1111/adb.13278.Peer-Reviewed Original ResearchConceptsPositive alcohol expectanciesAlcohol Use Disorders Identification TestAlcohol expectanciesAlcohol use disorderNeural correlatesCue responsesPath analysisProblem drinkingAlcohol misuseEffect of ageAUDIT scoresRostral anterior cingulate cortexWhole-brain regressionAlcohol cue exposureMiddle occipital cortexModerate alcohol use disorderAlcohol Expectancy QuestionnaireAnterior cingulate cortexAlcohol use severityBilateral rostral anterior cingulate cortexPsychological mechanismsBilateral parahippocampal gyrusCue exposureNeural processesSeverity of problems
2022
Shared and distinct neural activity during anticipation and outcome of win and loss: A meta-analysis of the monetary incentive delay task
Chen Y, Chaudhary S, Li C. Shared and distinct neural activity during anticipation and outcome of win and loss: A meta-analysis of the monetary incentive delay task. NeuroImage 2022, 264: 119764. PMID: 36427755, PMCID: PMC9837714, DOI: 10.1016/j.neuroimage.2022.119764.Peer-Reviewed Original ResearchConceptsSupplementary motor areaMonetary incentive delay taskMedial orbitofrontal cortexBilateral anterior insulaLoss outcomesAnterior insulaLoss anticipationIncentive delay taskBilateral striatumPrecentral gyrusCingulate cortexBilateral medial orbitofrontal cortexDorsal anterior cingulate cortexRight occipital cortexDelay taskAnterior cingulate cortexPosterior cingulate cortexNeural correlatesActivation likelihood estimationRight thalamusMotor areaOccipital cortexRegional activityDistinct neural activityStriatum
2021
Lower prefrontal cortical synaptic vesicle binding in cocaine use disorder: An exploratory 11C‐UCB‐J positron emission tomography study in humans
Angarita GA, Worhunsky PD, Naganawa M, Toyonaga T, Nabulsi NB, Li C, Esterlis I, Skosnik PD, Radhakrishnan R, Pittman B, Gueorguieva R, Potenza MN, Finnema SJ, Huang Y, Carson RE, Malison RT. Lower prefrontal cortical synaptic vesicle binding in cocaine use disorder: An exploratory 11C‐UCB‐J positron emission tomography study in humans. Addiction Biology 2021, 27: e13123. PMID: 34852401, PMCID: PMC8891080, DOI: 10.1111/adb.13123.Peer-Reviewed Original ResearchConceptsCocaine use disorderAnterior cingulate cortexRecent cocaine useSynaptic densityMedial orbitofrontal cortexPrefrontal cortexCocaine useOrbitofrontal cortexUse disordersVentromedial prefrontal cortexPositron emission tomography scanPositron emission tomography studyEmission tomography scanSynaptic vesicle glycoprotein 2AHealthy control subjectsVolume of distributionEmission tomography studiesAcute cocaineControl subjectsTomography scanCocaine exposurePreclinical studiesHC subjectsDendritic spinesLifetime cocaine useGray matter volumes of the insula and anterior cingulate cortex and their dysfunctional roles in cigarette smoking
Chen Y, Chaudhary S, Wang W, Li C. Gray matter volumes of the insula and anterior cingulate cortex and their dysfunctional roles in cigarette smoking. Addiction Neuroscience 2021, 1: 100003. PMID: 37220533, PMCID: PMC10201991, DOI: 10.1016/j.addicn.2021.100003.Peer-Reviewed Original ResearchGray matter volumeAnterior cingulate cortexYears of smokingHeavy smokersMatter volumeCingulate cortexSalience networkSmaller gray matter volumeSupplementary motor areaNicotine dependence scoresDorsal anterior cingulate cortexVoxel-based morphometryStructural imaging studiesMedial prefrontal cortexInternalizing scoresChronic smokingCigarette smokingFagerstrom TestInsula gray matter volumeMotor areaNicotine addictionSmokersSmokingImaging studiesDependence scoresSex differences in attention deficit hyperactivity symptom severity and functional connectivity of the dorsal striatum in young adults
Chen Y, Li G, Ide J, Luo X, Li C. Sex differences in attention deficit hyperactivity symptom severity and functional connectivity of the dorsal striatum in young adults. Neuroimage Reports 2021, 1: 100025. DOI: 10.1016/j.ynirp.2021.100025.Peer-Reviewed Original ResearchAttention deficit hyperactivity disorderADHD total scoreGroup 2Functional connectivityDorsal striatumGroup 3Symptom severityGroup 1Sex differencesTotal scoreFrontal gyrusRight inferior parietal gyrusRight superior frontal gyrusBasal ganglia dysfunctionCaudate functional connectivitySupplementary motor areaDorsal anterior cingulate cortexAnterior cingulate cortexSeed-based correlationSuperior frontal gyrusGreater symptom severityInferior parietal gyrusDeficit hyperactivity disorderGanglia dysfunctionInferior frontal gyrusNeural correlates of individual variation in two-back working memory and the relationship with fluid intelligence
Li G, Chen Y, Le TM, Wang W, Tang X, Li CR. Neural correlates of individual variation in two-back working memory and the relationship with fluid intelligence. Scientific Reports 2021, 11: 9980. PMID: 33976306, PMCID: PMC8113462, DOI: 10.1038/s41598-021-89433-8.Peer-Reviewed Original ResearchConceptsDorsal anterior cingulate cortexN-back performanceRight anterior insulaStandard Progressive Matrices testFluid intelligenceNeural correlatesReaction timePre-supplementary motor areaRaven's Standard Progressive Matrices testN-back taskIndividual variationHuman Connectome Project datasetProgressive Matrices TestProlonged response timeBilateral frontoparietal cortexAnterior cingulate cortexTwo-backNeural basisDorsal precuneusRSPM performanceNeural processesNeural substratesAnterior insulaCerebral correlatesCorrect itemsDistinct patterns of prefrontal cortical disengagement during inhibitory control in addiction: A meta-analysis based on population characteristics
Le TM, Potvin S, Zhornitsky S, Li CR. Distinct patterns of prefrontal cortical disengagement during inhibitory control in addiction: A meta-analysis based on population characteristics. Neuroscience & Biobehavioral Reviews 2021, 127: 255-269. PMID: 33933507, PMCID: PMC8411123, DOI: 10.1016/j.neubiorev.2021.04.028.Peer-Reviewed Original ResearchConceptsDorsal anterior cingulate cortexMiddle frontal gyrusHealthy controlsLeft dorsal anterior cingulate cortexMFG activationSubstance use statusPrefrontal cortical dysfunctionAnterior cingulate cortexPrefrontal cortical regionsResponse inhibitionPopulation characteristicsImpaired task performanceInhibitory control deficitsCortical dysfunctionCerebral functionBenefits of abstinenceNicotine usersCortical activationCingulate cortexCortical regionsFrontal gyrusBrain activationDrug addictionUse statusControl deficits
2020
Neural Responses to Reward in a Gambling Task: Sex Differences and Individual Variation in Reward-Driven Impulsivity
Li G, Zhang S, Le TM, Tang X, Li CR. Neural Responses to Reward in a Gambling Task: Sex Differences and Individual Variation in Reward-Driven Impulsivity. Cerebral Cortex Communications 2020, 1: tgaa025. PMID: 32864617, PMCID: PMC7446303, DOI: 10.1093/texcom/tgaa025.Peer-Reviewed Original ResearchGambling TaskNeural processesImpulse controlRegional activationSex differencesDorsal anterior cingulate cortexPrefrontal cortical activationAnterior cingulate cortexReaction timeHuman Connectome ProjectCautious respondingReward sensitivityIndividual variationNeural responsesBehavioral measuresAngular gyrusLonger reaction timesPrefrontal cortexImpulsivityCingulate cortexCortical activationConnectome ProjectHigher activationTaskRewardAge-Related Changes in the Neural Processes of Reward-Directed Action and Inhibition of Action
Le TM, Chao H, Levy I, Li CR. Age-Related Changes in the Neural Processes of Reward-Directed Action and Inhibition of Action. Frontiers In Psychology 2020, 11: 1121. PMID: 32587547, PMCID: PMC7298110, DOI: 10.3389/fpsyg.2020.01121.Peer-Reviewed Original ResearchInhibition of actionFunctional brain changesRostral anterior cingulate cortexWhole-brain multiple regressionAnterior cingulate cortexMiddle frontal gyrusAge-related changesFunctional magnetic resonanceBrain changesPostcentral gyrusCingulate cortexAnterior insulaFrontal gyrusTrialsProlonged response timeSuccess trialsGo trialsNeural activationReward-directed actionNegative modulationAgeAction inhibitionBrain substratesAge-related slowingReduced activity
2019
Neural correlates of reward-directed action and inhibition of action
Le TM, Zhang S, Zhornitsky S, Wang W, Li CR. Neural correlates of reward-directed action and inhibition of action. Cortex 2019, 123: 42-56. PMID: 31747630, DOI: 10.1016/j.cortex.2019.10.007.Peer-Reviewed Original ResearchConceptsRostral anterior cingulate cortexInhibition of actionGo trialsReward-directed actionGoal-directed actionsInferior parietal cortexMiddle frontal cortexAnterior cingulate cortexMain effectSignificant main effectVisual attentionNeural correlatesGo taskResponse executionReward valuationNeural processesBrain activationHealthy human adultsNeural responsesReward magnitudeConjunction analysisLarge rewardDorsal ACCCingulate cortexParietal cortexInterdependent Neural Correlates of Reward and Punishment Sensitivity During Rewarded Action and Inhibition of Action
Le TM, Wang W, Zhornitsky S, Dhingra I, Zhang S, Li CR. Interdependent Neural Correlates of Reward and Punishment Sensitivity During Rewarded Action and Inhibition of Action. Cerebral Cortex 2019, 30: 1662-1676. PMID: 31667492, PMCID: PMC7132903, DOI: 10.1093/cercor/bhz194.Peer-Reviewed Original ResearchConceptsInhibition of actionNeural correlatesReinforcement Sensitivity TheoryRostral anterior cingulate cortexMiddle frontal gyrusAnterior cingulate cortexPunishment sensitivityReinforcement sensitivityMFG activityIndividual differencesNeural processesReward QuestionnaireTrait sensitivityBrain correlatesNeural substratesFrontal gyrusGo responseRewarded actionsSensitivity theoryIncorrect responsesMediation analysisCingulate cortexRegional activationBehavioral approachAvoidance behaviorThe effects of age on cerebral responses to self-initiated actions during social interactions: An exploratory study
Wang W, Zhornitsky S, Chao HH, Levy I, Joormann J, Li CR. The effects of age on cerebral responses to self-initiated actions during social interactions: An exploratory study. Behavioural Brain Research 2019, 378: 112301. PMID: 31644928, PMCID: PMC6893150, DOI: 10.1016/j.bbr.2019.112301.Peer-Reviewed Original ResearchConceptsSelf-initiated actionsSocial interactionSocial anxietyCyberball taskNeural processesOccipital cortexBall tossPregenual anterior cingulate cortexAnterior cingulate cortexSex differencesSocial exclusionAnxiety Scale scoresBehavioral performanceOrbitofrontal cortexCingulate cortexSubjective reportsBehavioral burdenEffect of ageObserved sex differencesYoung adultsCerebral responsesAge-related diminutionGame sessionsAnxietyCortexStriatal functional connectivity in chronic ketamine users: a pilot study
Hung CC, Zhang S, Chen CM, Duann JR, Lin CP, Lee TS, Li CR. Striatal functional connectivity in chronic ketamine users: a pilot study. The American Journal Of Drug And Alcohol Abuse 2019, 46: 31-43. PMID: 31264888, PMCID: PMC8627683, DOI: 10.1080/00952990.2019.1624764.Peer-Reviewed Original ResearchConceptsDuration of useChronic ketamine usersKetamine usersKetamine useKetamine misuseOrbitofrontal cortexFunctional connectivityStriatal functional connectivityState functional connectivityLeft orbitofrontal cortexBIS-11 scoresDorsal anterior cingulate cortexVoxel-wise connectivityAnterior cingulate cortexMagnetic resonance imagingOFC connectivityHealthy controlsBilateral cerebellumStriatal connectivityCingulate cortexResonance imagingControl dysfunctionVentral striatumZ-scorePilot study
2018
Exploring Age-Related Changes in Resting State Functional Connectivity of the Amygdala: From Young to Middle Adulthood
Xiao T, Zhang S, Lee LE, Chao HH, van Dyck C, Li CR. Exploring Age-Related Changes in Resting State Functional Connectivity of the Amygdala: From Young to Middle Adulthood. Frontiers In Aging Neuroscience 2018, 10: 209. PMID: 30061823, PMCID: PMC6055042, DOI: 10.3389/fnagi.2018.00209.Peer-Reviewed Original ResearchResting-state functional connectivityAmygdala resting-state functional connectivityDorsal medial prefrontal cortexAnterior cingulate cortexAge-related differencesFunctional connectivityEmotion regulationAge-related changesPrefrontal cortexPositive resting-state functional connectivityNegative rsFCCingulate cortexEmotion regulatory mechanismsMiddle adulthoodVentromedial prefrontal cortexLife-span developmentState functional connectivityPosterior cingulate cortexMedial prefrontal cortexCognitive processingMaladaptive developmentAmygdala interactionsEmotional disordersIntrinsic connectivityAmygdala circuitsThalamic Cortical Error–Related Responses in Adult Social Drinkers: Sex Differences and Problem Alcohol Use
Ide JS, Zhornitsky S, Chao HH, Zhang S, Hu S, Wang W, Krystal JH, Li CR. Thalamic Cortical Error–Related Responses in Adult Social Drinkers: Sex Differences and Problem Alcohol Use. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2018, 3: 868-877. PMID: 29859929, PMCID: PMC6177312, DOI: 10.1016/j.bpsc.2018.04.008.Peer-Reviewed Original ResearchConceptsWhole-brain linear regressionError-related activationSex differencesBilateral dorsal anterior cingulate cortexAlcohol Use Disorders Identification Test (AUDIT) scoresSocial drinkersDorsal anterior cingulate cortexSubstance use disordersAnterior cingulate cortexFunctional magnetic resonance imagingMagnetic resonance imagingSuperior temporal cortexStatistical parametric mappingProblem alcohol useBilateral thalamusAlcohol drinkersAdult social drinkersStop-signal taskMale social drinkersTemporal cortexUse disordersCerebral activationIndependent sample t-testCingulate cortexSubcortical regionsResting state functional connectivity of the amygdala and problem drinking in non-dependent alcohol drinkers
Hu S, Ide JS, Chao HH, Zhornitsky S, Fischer KA, Wang W, Zhang S, Li CR. Resting state functional connectivity of the amygdala and problem drinking in non-dependent alcohol drinkers. Drug And Alcohol Dependence 2018, 185: 173-180. PMID: 29454928, PMCID: PMC5889735, DOI: 10.1016/j.drugalcdep.2017.11.026.Peer-Reviewed Original ResearchConceptsState functional connectivityDorsal anterior cingulate cortexAlcohol misuseAlcohol drinkersFunctional connectivityInvolvement scoreProblem drinkingSubstance useWhole-brain rsFCComorbid substance useAmygdala-prefrontal cortical circuitAnterior cingulate cortexStatistical parametric mappingPotential sex differencesPrefrontal cortical structuresAmygdala connectivityCortical functionCortical circuitsCingulate cortexAmygdalaCortical structuresParametric mappingSex differencesDrinkingDrinkers