2015
Role of VGF-Derived Carboxy-Terminal Peptides in Energy Balance and Reproduction: Analysis of “Humanized” Knockin Mice Expressing Full-Length or Truncated VGF
Sadahiro M, Erickson C, Lin WJ, Shin AC, Razzoli M, Jiang C, Fargali S, Gurney A, Kelley KA, Buettner C, Bartolomucci A, Salton SR. Role of VGF-Derived Carboxy-Terminal Peptides in Energy Balance and Reproduction: Analysis of “Humanized” Knockin Mice Expressing Full-Length or Truncated VGF. Endocrinology 2015, 156: 1724-1738. PMID: 25675362, PMCID: PMC4398760, DOI: 10.1210/en.2014-1826.Peer-Reviewed Original ResearchConceptsEnergy expenditureRole of VGFWild-type miceKnockin mouse modelGlucose toleranceFemale miceGlucose homeostasisMouse modelBody weightReproductive functionKnockin miceVGF peptidesMiceVGF proteinMetabolic phenotypeInfertile miceSingle nucleotide polymorphismsFat storageTerminal peptidesTargeted deletionCarboxy-terminal peptideVGFObesityCritical regulatorC-terminal region
2013
The role of neurotrophins in major depressive disorder
Jiang C, Salton S. The role of neurotrophins in major depressive disorder. Translational Neuroscience 2013, 4: 46-58. PMID: 23691270, PMCID: PMC3656715, DOI: 10.2478/s13380-013-0103-8.Peer-Reviewed Original ResearchBrain-derived neurotrophic factorDepressive behaviorRole of neurotrophinsMajor depressive disorderTransgenic mouse modelStability of synapsesComplex brain circuitryAntidepressant effectsDendritic lengthSpine densityNeurotrophic factorDepressive disorderNeuronal cytoarchitectureNucleus accumbensMouse modelAnalyses of knockoutBrain circuitryPrefrontal cortexNeurotrophinsGrowth factorSingle nucleotide polymorphismsCritical modulatorHuman genetic studiesSubtle alterationsNucleotide polymorphisms