Embryonic ablation of neuronal VGF increases energy expenditure and reduces body weight
Jiang C, Lin WJ, Sadahiro M, Shin AC, Buettner C, Salton SR. Embryonic ablation of neuronal VGF increases energy expenditure and reduces body weight. Neuropeptides 2016, 64: 75-83. PMID: 28024880, PMCID: PMC5478485, DOI: 10.1016/j.npep.2016.12.005.Peer-Reviewed Original ResearchConceptsVGF knockout miceKnockout miceBody weightPeripheral endocrineEnergy expenditureAdult miceVGF-derived peptide TLQP-21Peptide TLQP-21Diet-induced obesityEmbryonic CNS neuronsICV deliverySynapsin-CreAAV-CreTLQP-21Arcuate nucleusCNS neuronsVentromedial hypothalamusReduced adiposityFemale miceMale miceEmbryonic ablationAdult neuronsExcitatory neuronsHypermetabolic phenotypeEmbryonic neurons