2016
Energy sources identify metabolic phenotypes in pancreatic cancer
Liang C, Qin Y, Zhang B, Ji S, Shi S, Xu W, Liu J, Xiang J, Liang D, Hu Q, Liu L, Liu C, Luo G, Ni Q, Xu J, Yu X. Energy sources identify metabolic phenotypes in pancreatic cancer. Acta Biochimica Et Biophysica Sinica 2016, 48: 969-979. PMID: 27649892, DOI: 10.1093/abbs/gmw097.Peer-Reviewed Original ResearchConceptsPancreatic ductal adenocarcinomaWarburg phenotypeMetabolic phenotypeInducing different metabolic phenotypesCancer metabolic reprogrammingPancreatic ductal adenocarcinoma treatmentHallmarks of cancerStratified pancreatic ductal adenocarcinomaIndividual metabolic phenotypeMetabolic reprogrammingMetabolic pathwaysMetabolic typeDuctal adenocarcinomaMalignant tumorsHeterogeneous diseasePhenotypeTherapeutic approachesEnergy metabolismMetabolic featuresMetabolic diseasesMetabolic inhibitorsNutritional substratesMetabolite detectionDiseaseGlutaminolysis
2014
The UPF1 RNA surveillance gene is commonly mutated in pancreatic adenosquamous carcinoma
Liu C, Karam R, Zhou Y, Su F, Ji Y, Li G, Xu G, Lu L, Wang C, Song M, Zhu J, Wang Y, Zhao Y, Foo W, Zuo M, Valasek M, Javle M, Wilkinson M, Lu Y. The UPF1 RNA surveillance gene is commonly mutated in pancreatic adenosquamous carcinoma. Nature Medicine 2014, 20: 596-598. PMID: 24859531, PMCID: PMC4048332, DOI: 10.1038/nm.3548.Peer-Reviewed Original ResearchMeSH KeywordsAlternative SplicingBase SequenceCarcinoma, AdenosquamousGene ComponentsHEK293 CellsHumansImmunohistochemistryIn Situ Nick-End LabelingMolecular Sequence DataMutagenesisMutationNonsense Mediated mRNA DecayPancreatic NeoplasmsReal-Time Polymerase Chain ReactionReverse Transcriptase Polymerase Chain ReactionRNA HelicasesSequence Analysis, DNATrans-Activators