2021
Fibrinogen/Albumin Ratio as a Promising Marker for Predicting Survival in Pancreatic Neuroendocrine Neoplasms
Deng S, Fan Z, Xia H, Gong Y, Qian Y, Huang Q, Cheng H, Jin K, Xiao Z, Luo G, Yu X, Liu C. Fibrinogen/Albumin Ratio as a Promising Marker for Predicting Survival in Pancreatic Neuroendocrine Neoplasms. Cancer Management And Research 2021, 13: 107-115. PMID: 33447083, PMCID: PMC7802789, DOI: 10.2147/cmar.s275173.Peer-Reviewed Original ResearchProgression-free survivalFibrinogen/albumin ratioIndependent risk factorOverall survivalPoor OSPan-NENsCutoff valuePrognostic valueMultivariate analysisAssociated with poor OSRisk factorsGrade 3 tumorsStage IV tumorsOptimal cutoff valuePancreatic neuroendocrine neoplasmsNonfunctioning tumorsIV tumorsNeuroendocrine neoplasmsPrimary endpointSecondary endpointsPredictive biomarkersClinicopathological characteristicsPredicting prognosisUnivariate analysisPredicting survival
2020
Dynamics and Correlation Among Viral Positivity, Seroconversion, and Disease Severity in COVID-19
Fu Y, Li Y, Guo E, He L, Liu J, Yang B, Li F, Wang Z, Li Y, Xiao R, Liu C, Huang Y, Wu X, Lu F, You L, Qin T, Wang C, Li K, Wu P, Ma D, Sun C, Chen G. Dynamics and Correlation Among Viral Positivity, Seroconversion, and Disease Severity in COVID-19. Annals Of Internal Medicine 2020, 174: m20-3337. PMID: 33284684, PMCID: PMC7745119, DOI: 10.7326/m20-3337.Peer-Reviewed Original ResearchConceptsIndependent risk factorLaboratory-confirmed COVID-19Noncritically ill patientsViral positivityCritically ill patientsIll patientsDisease severityLow IgM titersRisk factorsViral polymerase chain reactionIgM titersCourse of coronavirus disease 2019Serum inflammatory markersIgM positive rateClinically diagnosed casesIgG positivity rateViral positivity rateMedian durationSpecialty care centersSeroconversion ratesAdult patientsInflammatory markersSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Polymerase chain reactionPrior history of acute pancreatitis predicts poor survival in patients with resectable pancreatic ductal adenocarcinoma
Gong Y, Fan Z, Luo G, Huang Q, Qian Y, Cheng H, Jin K, Ni Q, Yu X, Liu C. Prior history of acute pancreatitis predicts poor survival in patients with resectable pancreatic ductal adenocarcinoma. Pancreatology 2020, 20: 716-721. PMID: 32249060, DOI: 10.1016/j.pan.2020.02.016.Peer-Reviewed Original ResearchConceptsHistory of APPancreatic ductal adenocarcinomaResectable pancreatic ductal adenocarcinomaPancreatic ductal adenocarcinoma patientsLog-rank testAcute pancreatitisSurgical resectionDuctal adenocarcinomaPoor survivalHazard ratioHistory of acute pancreatitisDiagnosis of pancreatic ductal adenocarcinomaAssociated with poor survivalIndependent survival predictorMultivariable-adjusted hazard ratiosKaplan-Meier methodRetrospective cohort studyCox proportional hazards modelsProportional hazards modelOverall survivalRemote historyClinical characteristicsCohort studyMultivariate analysisRisk factors
2017
Epigenetic Regulations in the Pathogenesis of HCC and the Clinical Application
Puszyk W, Robertson K, Liu C. Epigenetic Regulations in the Pathogenesis of HCC and the Clinical Application. 2017, 69-93. DOI: 10.1007/978-3-319-68082-8_5.Peer-Reviewed Original ResearchNonalcoholic fatty liver diseaseDevelopment of hepatocellular carcinomaHepatocellular carcinoma casesHepatocellular carcinomaHepatitis B virusHepatitis C virusRisk factorsChronic infectionNonalcoholic steatohepatitisViral hepatocellular carcinomaChronic cigarette smokingIndependent risk factorPathogenesis of hepatocellular carcinomaConsumption of excess caloriesLiver cancer casesFatty liver diseaseProgress to nonalcoholic steatohepatitisExposure to environmental factorsHCC casesLiver malignanciesConsumption of alcoholCancer casesB virusC virusLiver disease
2013
Linking metabolism and epigenetic regulation in development of hepatocellular carcinoma
Puszyk W, Le Trinh T, Chapple S, Liu C. Linking metabolism and epigenetic regulation in development of hepatocellular carcinoma. Laboratory Investigation 2013, 93: 983-990. PMID: 23917878, PMCID: PMC4028619, DOI: 10.1038/labinvest.2013.94.Peer-Reviewed Original ResearchConceptsHepatocellular carcinomaLate-stage hepatocellular carcinomaDevelopment of HCCAltered liver metabolismHepatitis B virusMajor risk factorProgression of HCCHepatitis CLiver functionB virusMicro RNA expressionRisk factorsLiver metabolismMetabolic organSurvival rateCancerRNA expressionCommon formCarcinomaUnderlying metabolic processesLiverExogenous environmental factorsEnvironmental factorsExcessive consumptionExposure
2012
Regulation of intestinal inflammation by microbiota following allogeneic bone marrow transplantation
Jenq R, Ubeda C, Taur Y, Menezes C, Khanin R, Dudakov J, Liu C, West M, Singer N, Equinda M, Gobourne A, Lipuma L, Young L, Smith O, Ghosh A, Hanash A, Goldberg J, Aoyama K, Blazar B, Pamer E, van den Brink M. Regulation of intestinal inflammation by microbiota following allogeneic bone marrow transplantation. Journal Of Experimental Medicine 2012, 209: 903-911. PMID: 22547653, PMCID: PMC3348096, DOI: 10.1084/jem.20112408.Peer-Reviewed Original ResearchConceptsAllogeneic bone marrow transplantationBone marrow transplantationIntestinal inflammationMarrow transplantationAllogeneic BMT recipientsPotential risk factorsSubsequent GVHDHost diseaseBMT recipientsRisk factorsGVHDMouse modelResident gut microbesInflammationIntestinal microbiotaSignificant protectionGut floraHuman recipientsHuman floraInitial onsetGut microbesLongitudinal studyTransplantationMicrobiotaMice
2009
NOD2 regulates hematopoietic cell function during graft-versus-host disease
Penack O, Smith O, Cunningham-Bussel A, Liu X, Rao U, Yim N, Na I, Holland A, Ghosh A, Lu S, Jenq R, Liu C, Murphy G, Brandl K, van den Brink M. NOD2 regulates hematopoietic cell function during graft-versus-host disease. Journal Of Experimental Medicine 2009, 206: 2101-2110. PMID: 19737867, PMCID: PMC2757869, DOI: 10.1084/jem.20090623.Peer-Reviewed Original ResearchConceptsAntigen-presenting cellsNOD2 deficiencyHost diseaseCrohn's diseaseExperimental allogeneic bone marrow transplantationAllogeneic bone marrow transplantationHost antigen-presenting cellsAllo-BMT recipientsDevelopment of GVHDExperimental colitis modelHematopoietic cellsHost hematopoietic cellsDonor T cellsIndependent risk factorBone marrow chimerasBone marrow transplantationChimeric recipientsIntestinal inflammationProinflammatory stateColitis modelMarrow transplantationNOD2 mutationsRisk factorsT cellsPaneth cells
2005
40 THE NATURAL HISTORY OF CRYPTOGENIC CIRRHOSIS FOLLOWING ORTHOTOPIC LIVER TRANSPLANTATION: A HISTORICAL COHORT STUDY
Abdelmalek M, Mudaliar K, Liu C, Reed A, Nelson D, Asal N, Stacpoole P. 40 THE NATURAL HISTORY OF CRYPTOGENIC CIRRHOSIS FOLLOWING ORTHOTOPIC LIVER TRANSPLANTATION: A HISTORICAL COHORT STUDY. Journal Of Investigative Medicine 2005, 53: s393. DOI: 10.2310/6650.2005.00205.39.Peer-Reviewed Original ResearchNonalcoholic fatty liver diseaseLiver transplantationCryptogenic cirrhosisSteatosis gradeClinical dataMean age 53Repeat liver transplantationYr post-LTFatty liver diseaseInsulin resistance syndromeCardiovascular disease deathsPost-LTPre-LTMELD scoreGlycemic controlHDL cholesterolLiver biopsyInflammatory activityLDL cholesterolLiver diseaseDisease deathsResistance syndromeSingle pathologistClinicopathologic correlationRisk factors