2013
Atypical E2F Dependent Dysregulation Of Cell Cycling By Microrna-142 Regulates T-Cell Responses and Experimental Graft-Versus-Host Disease
Sun Y, Oravecz-Wilson K, Saunders T, Wang Y, Toubai T, Mathewson N, Liu C, Hou G, Cummings E, Ross C, Reddy P. Atypical E2F Dependent Dysregulation Of Cell Cycling By Microrna-142 Regulates T-Cell Responses and Experimental Graft-Versus-Host Disease. Blood 2013, 122: 136. DOI: 10.1182/blood.v122.21.136.136.Peer-Reviewed Original ResearchT cell responsesKO T cellsWT T cellsT cellsGVHD mortalityCell responsesDay 7 post-BMTBALB/c animalsRatio of TregPeripheral blood examinationDonor T cellsT cell immunityBone marrow studyMiR-142Conventional T cellsLower IL-2Naïve T cellsSecondary lymphoid organsIL-6 productionSimilar absolute numbersNovel therapeutic strategiesT cell cyclingWT littermate controlsSignificant differencesImmune system function
2007
Lymphopenia-induced proliferation of donor T cells reduces their capacity for causing acute graft-versus-host disease
Maeda Y, Tawara I, Teshima T, Liu C, Hashimoto D, Matsuoka K, Tanimoto M, Reddy P. Lymphopenia-induced proliferation of donor T cells reduces their capacity for causing acute graft-versus-host disease. Experimental Hematology 2007, 35: 274-286. PMID: 17258076, DOI: 10.1016/j.exphem.2006.10.010.Peer-Reviewed Original ResearchConceptsAllogeneic bone marrow transplantationDonor T cellsBone marrow transplantationLymphopenia-induced proliferationNaïve T cellsT cellsHost diseaseAcute GVHD severityAnti-tumor immunityT cell subsetsPhenotype T cellsMurine experimental modelAnti-tumor functionAcute graftGVHD mortalitySevere GVHDGVHD severityAllograft rejectionMarrow transplantationCell depletionCell subsetsGVHDBiochemical parametersExperimental modelGraft