2015
RIG-I-Induced Type I IFNs Promote Regeneration of the Intestinal Stem Cell Compartment during Acute Tissue Damage
Fischer J, Bscheider M, Eisenkolb G, Wintges A, Lindemans C, Heidegger S, Monette S, Calafiore M, Rodriguez K, Lieberman S, Liu C, Peschel C, Docampo M, Velardi E, Jenq R, Hanash A, Dudakov J, Haas T, van den Brink M, Poeck H. RIG-I-Induced Type I IFNs Promote Regeneration of the Intestinal Stem Cell Compartment during Acute Tissue Damage. Blood 2015, 126: 3072. DOI: 10.1182/blood.v126.23.3072.3072.Peer-Reviewed Original ResearchTotal body irradiationEpithelial regenerationAllogeneic hematopoietic stem cell transplantationHematopoietic stem cell transplantationAcute intestinal injuryEpithelial cellsIntestinal barrier damageStem cell transplantationAcute tissue damageType I IFNsType I IFNActivation of RIGInnovative therapeutic strategiesIntestinal epithelial cellsRegenerative functionMechanism of actionHost diseaseIntestinal injuryBody irradiationBarrier damageCell transplantationDeficient miceViral challengePreclinical modelsWorse graft
2014
IL-22 Is an Intestinal Stem Cell Growth Factor, and IL-22 Administration in Vivo Reduces Morbidity and Mortality in Murine GvHD
Lindemans C, Mertelsmann A, O’Connor M, Dudakov J, Jenq R, Velardi E, Young L, Smith O, Lawrence G, Luo N, Ivanov J, Hua G, Martin M, Liu C, Kolesnick R, Van Den Brink M, Hanash A. IL-22 Is an Intestinal Stem Cell Growth Factor, and IL-22 Administration in Vivo Reduces Morbidity and Mortality in Murine GvHD. Blood 2014, 124: 651. DOI: 10.1182/blood.v124.21.651.651.Peer-Reviewed Original ResearchInnate lymphoid cellsIL-22 administrationIL-22Small intestineLymphoid cellsGut GVHDGrowth factorAllogeneic hematopoietic stem cell transplantationDay sevenWild-type B6 miceHematopoietic stem cell transplantationStroma-derived growth factorsAllo-HSCT modelClinical GVHD scoresExpansion of Lgr5Post-transplant immunodeficiencyStem cell transplantationNumber of Lgr5Paneth cell numbersGut microbial floraCell growth factorMechanism of actionGVHD pathologyGVHD scoresReduces Morbidity
2011
Survivin inhibition is critical for Bcl‐2 family inhibitor, ABT‐263 to induce apoptosis in liver cancer cells
zhao X, Ogunwobi O, Nelson D, Liu C. Survivin inhibition is critical for Bcl‐2 family inhibitor, ABT‐263 to induce apoptosis in liver cancer cells. The FASEB Journal 2011, 25: 563.13-563.13. DOI: 10.1096/fasebj.25.1_supplement.563.13.Peer-Reviewed Original ResearchYM-155Liver cancer cellsABT-263HCC cellsProtein expressionCancer cellsABT-263 treatmentNormal hepatocytesMechanism of actionHCC cell apoptosisBcl-2 inhibitorsSurvivin protein expressionBcl-2 family inhibitorsHCC managementSignificant apoptotic effectHigh dosesLow dosesSurvivin expressionNovel Bcl-2 inhibitorSurvivin inhibitionSurvivin inhibitorChemotherapeutic alternativesInhibitory effectCell apoptosisSurvivin siRNA
2008
Histone deacetylase inhibition modulates indoleamine 2,3-dioxygenase–dependent DC functions and regulates experimental graft-versus-host disease in mice
Reddy P, Sun Y, Toubai T, Duran-Struuck R, Clouthier S, Weisiger E, Maeda Y, Tawara I, Krijanovski O, Gatza E, Liu C, Malter C, Mascagni P, Dinarello C, Ferrara J. Histone deacetylase inhibition modulates indoleamine 2,3-dioxygenase–dependent DC functions and regulates experimental graft-versus-host disease in mice. Journal Of Clinical Investigation 2008, 118: 2562-2573. PMID: 18568076, PMCID: PMC2430497, DOI: 10.1172/jci34712.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CDBone Marrow TransplantationCytokinesDendritic CellsEnzyme InhibitorsFemaleGene ExpressionGraft vs Host DiseaseHistone Deacetylase InhibitorsHumansHydroxamic AcidsIndoleamine-Pyrrole 2,3,-DioxygenaseLipopolysaccharidesLymphocyte ActivationMiceMice, Inbred BALB CMice, Inbred C3HMice, Inbred C57BLMice, Inbred StrainsMice, KnockoutRNA, Small InterferingSurvival AnalysisT-LymphocytesVorinostatConceptsDC functionHDAC inhibitorsSuberoylanilide hydroxamic acidHost diseaseExperimental graftBlockade of IDOPretreatment of DCsAllogeneic BM transplantationBM-derived cellsImmune-mediated diseasesExpression of CD40Expression of indoleamineBM transplantation modelExposure of DCsInduction of IDOVivo functional roleHistone deacetylase inhibitionHistone deacetylase inhibitorsMechanism of actionProinflammatory cytokinesBM transplantationWT DCsTransplantation modelImmunomodulatory functionsDeacetylase inhibition