2007
A Novel Role for the Semaphorin Sema4D in the Induction of Allo-responses
Duran-Struuck R, Tawara I, Lowler K, Clouthier S, Weisiger E, Rogers C, Luker G, Kumanogoh A, Liu C, Ferrara J, Reddy P. A Novel Role for the Semaphorin Sema4D in the Induction of Allo-responses. Transplantation And Cellular Therapy 2007, 13: 1294.e1-1294.e11. PMID: 17950916, PMCID: PMC2278022, DOI: 10.1016/j.bbmt.2007.07.014.Peer-Reviewed Original ResearchConceptsBone marrow transplantT cellsWT T cellsDendritic cellsBALB/c recipient miceIntrinsic T cell defectPreservation of GVLAllo-immune responsesLess TNF-alphaTumor-free survivalT cell defectsAntigen presenting cellsWild-type T cellsCertain immune responsesP815 murine mastocytoma cell lineT cell-APC interactionsFree survivalHost diseaseIL-12p70Leukemia responseOrgan damageSema4D expressionMarrow transplantCytotoxic functionSyngeneic recipients
2004
Paradoxical effects of interleukin-18 on the severity of acute graft-versus-host disease mediated by CD4+ and CD8+ T-cell subsets after experimental allogeneic bone marrow transplantation
Min C, Maeda Y, Lowler K, Liu C, Clouthier S, Lofthus D, Weisiger E, Ferrara J, Reddy P. Paradoxical effects of interleukin-18 on the severity of acute graft-versus-host disease mediated by CD4+ and CD8+ T-cell subsets after experimental allogeneic bone marrow transplantation. Blood 2004, 104: 3393-3399. PMID: 15280194, DOI: 10.1182/blood-2004-02-0763.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAnimalsAntibodies, MonoclonalApoptosisBone Marrow TransplantationCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCytokinesDisease Models, AnimalFemaleGraft vs Host DiseaseHistocompatibility Antigens Class IHistocompatibility Antigens Class IIInterleukin-18Interleukin-18 Receptor alpha SubunitMiceMice, Inbred C57BLReceptors, InterleukinReceptors, Interleukin-18Severity of Illness IndexT-Lymphocytes, CytotoxicTransplantation, HomologousConceptsAllogeneic bone marrow transplantationBone marrow transplantationExperimental allogeneic bone marrow transplantationDonor T cellsIL-18T cellsAcute GVHDAcute graftHost diseaseInterleukin-18Marrow transplantationClinical allogeneic bone marrow transplantationMajor histocompatibility complex class IIHistocompatibility complex class IIEndogenous IL-18Experimental acute graftT cell subsetsParadoxical effectFas-dependent mannerLess GVHDCytotoxic functionHistopathologic parametersGVHDClass IIFas expression