2015
Primary and secondary alterations of white matter connectivity in schizophrenia: A study on first-episode and chronic patients using whole-brain tractography-based analysis
Wu C, Hwang T, Chen Y, Hsu Y, Lo Y, Liu C, Hwu H, Liu C, Hsieh M, Chien Y, Chen C, Tseng W. Primary and secondary alterations of white matter connectivity in schizophrenia: A study on first-episode and chronic patients using whole-brain tractography-based analysis. Schizophrenia Research 2015, 169: 54-61. PMID: 26443482, DOI: 10.1016/j.schres.2015.09.023.Peer-Reviewed Original ResearchConceptsDorsolateral prefrontal cortexBilateral DLPFCFirst-episode patientsWhite matter connectivityFirst-episodeChronic patientsBilateral dorsolateral prefrontal cortexFirst-episode schizophreniaWidespread white matter abnormalitiesBilateral temporal polesDebilitating mental disorderReduced white matter connectivityRight arcuate fasciculusSuperior longitudinal fasciculus IDuration of illnessAssociated with clinical variablesCallosal fibersBetween-group analysisWhite matter tractsWhite matter abnormalitiesPrefrontal cortexImpaired connectivityTemporal poleArcuate fasciculusCerebral white matter
2011
Characterization of HCV Interactions with Toll-Like Receptors and RIG-I in Liver Cells
Eksioglu E, Zhu H, Bayouth L, Bess J, Liu H, Nelson D, Liu C. Characterization of HCV Interactions with Toll-Like Receptors and RIG-I in Liver Cells. PLOS ONE 2011, 6: e21186. PMID: 21695051, PMCID: PMC3117876, DOI: 10.1371/journal.pone.0021186.Peer-Reviewed Original ResearchMeSH KeywordsCell DeathCell Line, TumorDEAD Box Protein 58DEAD-box RNA HelicasesDown-RegulationHepacivirusHost-Pathogen InteractionsHumansInterferon-betaLiverProtein BindingReceptors, ImmunologicSignal TransductionTNF-Related Apoptosis-Inducing LigandToll-Like ReceptorsViral Envelope ProteinsVirus ReplicationConceptsHuh7.5 cellsViral replicationHCV chronic patientsExpression of TLR3Toll-like receptorsHCV envelope proteinsExpression levelsRIG-I expressionHCV interactionChronic patientsHCVTRAIL pathwayViral escapeViral infectionInnate immunityViral pathogenesisTLR3Induction of apoptosisAntiviral stateIFN inductionLow expression levelsLiver cellsLH86Envelope proteinIFN