2024
Automated detection of early signs of irreversible ischemic change on CTA source images in patients with large vessel occlusion
Mak A, Matouk C, Avery E, Behland J, Haider S, Frey D, Madai V, Vajkoczy P, Griessenauer C, Zand R, Hendrix P, Abedi V, Sanelli P, Falcone G, Petersen N, Sansing L, Sheth K, Payabvash S, Malhotra A. Automated detection of early signs of irreversible ischemic change on CTA source images in patients with large vessel occlusion. PLOS ONE 2024, 19: e0304962. PMID: 38870240, PMCID: PMC11175522, DOI: 10.1371/journal.pone.0304962.Peer-Reviewed Original ResearchConceptsDiffusion-weighted imagingLarge vessel occlusionIrreversible ischemic changesPoor functional outcomeFunctional outcomesIschemic changesInfarct volumeAlberta Stroke Program Early CT ScorePredicting poor functional outcomeVessel occlusionFollow-up diffusion-weighted imagingAnterior circulation LVO strokeCTA source imagesReceiver operating characteristic curveExpert human readersPredicting final infarctionASPECTS regionsAdmission CTANon-inferior performanceBaseline CTACT scoreFinal infarctEndovascular therapyHU attenuationValidation cohort
2023
Comprehensive analysis of the impact of procedure time and the ‘golden hour’ in subpopulations of stroke thrombectomy patients
Ash M, Dimisko L, Chalhoub R, Howard B, Cawley C, Matouk C, Pabaney A, Spiotta A, Jabbour P, Maier I, Wolfe S, T A, Kim J, Psychogios M, Mascitelli J, Starke R, Shaban A, Yoshimura S, De Leacy R, Kan P, Fragata I, Polifka A, Arthur A, Park M, Crosa R, Williamson R, Dumont T, Levitt M, Al Kasab S, Tjoumakaris S, Liman J, Saad H, Samaniego E, Fargen K, Grossberg J, Alawieh A. Comprehensive analysis of the impact of procedure time and the ‘golden hour’ in subpopulations of stroke thrombectomy patients. Journal Of NeuroInterventional Surgery 2023, 16: 1069-1075. PMID: 37875342, DOI: 10.1136/jnis-2023-020792.Peer-Reviewed Original ResearchSymptomatic intracranial hemorrhageSubpopulation of patientsProcedure timePosterior circulation strokeModified Rankin ScaleTissue plasminogen activatorEndovascular thrombectomyCirculation strokePoor outcomeGroin puncture to successful recanalizationAlberta Stroke Program Early CT ScoreAssociated with worse clinical outcomesRate of symptomatic intracranial hemorrhageIV tissue plasminogen activatorSymptomatic intracranial hemorrhage rateEffects of procedure timeIV tPA treatmentAge groupsOnset-to-groin timeAssociated with higher oddsAcute ischemic strokeCT scoreIntracranial hemorrhageDelayed presentationMulticenter study