2024
Inflammatory Response and Defects on Myelin Integrity in the Olfactory System of K18hACE2 Mice Infected with SARS-CoV-2
Martin-Lopez E, Brennan B, Mao T, Spence N, Meller S, Han K, Yahiaoui N, Wang C, Iwasaki A, Greer C. Inflammatory Response and Defects on Myelin Integrity in the Olfactory System of K18hACE2 Mice Infected with SARS-CoV-2. ENeuro 2024, 11: eneuro.0106-24.2024. PMID: 38834299, PMCID: PMC11185043, DOI: 10.1523/eneuro.0106-24.2024.Peer-Reviewed Original ResearchOlfactory bulbOlfactory epitheliumPiriform cortexOlfactory tractOlfactory systemSARS-CoV-2Projection neuronsMyelination defectsOlfactory sensory neuronsLateral olfactory tractLoss of olfactionRespiratory epithelial cellsLamina propria macrophagesSARS-CoV-2 infectionInfected SCDays of infectionIntegrity of myelinOlfactory dysfunctionInfected microgliaSensitive to infectionOlfactory deficitsSensory neuronsSustentacular cellsNasal cavityNeuronal conduction
2015
Dendrodendritic synapses in the mouse olfactory bulb external plexiform layer
Bartel DL, Rela L, Hsieh L, Greer CA. Dendrodendritic synapses in the mouse olfactory bulb external plexiform layer. The Journal Of Comparative Neurology 2015, 523: 1145-1161. PMID: 25420934, PMCID: PMC4390432, DOI: 10.1002/cne.23714.Peer-Reviewed Original ResearchConceptsExternal plexiform layerDendrodendritic synapsesPlexiform layerSynaptic densityOlfactory bulb projection neuronsReciprocal dendrodendritic synapsesGranule cell spinesPostsynaptic scaffolding proteinOdor informationIR punctaProjection neuronsSecondary dendritesInhibitory synapsesT cellsInhibitory inputsCell synapseGranule cellsSynaptic circuitsSynaptic propertiesCell bodiesSynapsesCurrent spreadDendritesSynapseTemporal coding
2014
Segregated labeling of olfactory bulb projection neurons based on their birthdates
Imamura F, Greer CA. Segregated labeling of olfactory bulb projection neurons based on their birthdates. European Journal Of Neuroscience 2014, 41: 147-156. PMID: 25393912, PMCID: PMC4300262, DOI: 10.1111/ejn.12784.Peer-Reviewed Original ResearchConceptsExternal plexiform layerMitral cell layerOlfactory bulb projection neuronsSuperficial external plexiform layerProjection neuronsMitral cellsOlfactory bulbInnervation patternSoma locationOB projection neuronsMain olfactory bulbAccessory olfactory bulbMouse olfactory bulbTiming of neurogenesisSecondary dendritesPlexiform layerCell dendritesBrdU injectionLaminar organizationUtero electroporationNeuronsDistinct subsetsEmbryonic dayCell layerMitral
2013
Pax6 regulates Tbr1 and Tbr2 expressions in olfactory bulb mitral cells
Imamura F, Greer CA. Pax6 regulates Tbr1 and Tbr2 expressions in olfactory bulb mitral cells. Molecular And Cellular Neuroscience 2013, 54: 58-70. PMID: 23353076, PMCID: PMC3622182, DOI: 10.1016/j.mcn.2013.01.002.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDNA-Binding ProteinsDopaminergic NeuronsEye ProteinsGABAergic NeuronsGene Expression Regulation, DevelopmentalHomeodomain ProteinsInterneuronsMiceMitosisNeural Stem CellsNeurogenesisNeurogliaOlfactory BulbPaired Box Transcription FactorsPAX6 Transcription FactorRepressor ProteinsT-Box Domain ProteinsConceptsExogenous expressionRegulation of Pax6Expression of Tbr1Mitral cell developmentCell precursorsFate determinationCell fateRadial glial cellsMitral cellsCell developmentTbr2 expressionPax6Embryonic olfactory bulbCortical projection neuronsOlfactory bulb mitral cellsPostmitotic precursorsPrecursor cellsUtero electroporationVentricular zoneNumber of cellsDopaminergic interneuronsTbr1Projection neuronsExpressionGlial cells
2010
Age-induced disruption of selective olfactory bulb synaptic circuits
Richard MB, Taylor SR, Greer CA. Age-induced disruption of selective olfactory bulb synaptic circuits. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 15613-15618. PMID: 20679234, PMCID: PMC2932573, DOI: 10.1073/pnas.1007931107.Peer-Reviewed Original ResearchConceptsMouse OBLayer-specific alterationsAfferent synaptic inputExternal plexiform layerPrimary sensory cortexAge-related alterationsAge-related cognitive deficitsNeuronal lossOlfactory bulb circuitryProjection neuronsPlexiform layerOB glomeruliQuantitative morphometric analysisSynaptic densityGlomerular layerInterneuron subpopulationsOlfactory functionOSN axonsSynaptic inputsSensory cortexOB layersSynaptic circuitsSensory functionOB circuitryCognitive deficits
2009
Dendritic Branching of Olfactory Bulb Mitral and Tufted Cells: Regulation by TrkB
Imamura F, Greer CA. Dendritic Branching of Olfactory Bulb Mitral and Tufted Cells: Regulation by TrkB. PLOS ONE 2009, 4: e6729. PMID: 19707543, PMCID: PMC2727791, DOI: 10.1371/journal.pone.0006729.Peer-Reviewed Original ResearchConceptsMitral/TrkB activationOlfactory bulbApical dendritesDendritic developmentLateral dendriteDendritic branchingExternal plexiform layerReciprocal dendrodendritic synapsesEarly postnatal daysOlfactory bulb mitralTrkB neurotrophin receptorMammalian olfactory bulbSame odor receptorOlfactory sensory neuronsTufted CellsDendrodendritic synapsesTrkB receptorsDendritic differentiationOB neuronsProjection neuronsPlexiform layerNeurotrophin receptorPostnatal daySensory neurons