2005
Psychotic Spectrum Disorders and Alcohol Abuse: A Review of Pharmacotherapeutic Strategies and a Report on the Effectiveness of Naltrexone and Disulfiram
Petrakis IL, Nich C, Ralevski E. Psychotic Spectrum Disorders and Alcohol Abuse: A Review of Pharmacotherapeutic Strategies and a Report on the Effectiveness of Naltrexone and Disulfiram. Schizophrenia Bulletin 2005, 32: 644-654. PMID: 16887890, PMCID: PMC2632271, DOI: 10.1093/schbul/sbl010.Peer-Reviewed Original ResearchConceptsPsychotic spectrum disordersPharmacotherapeutic strategiesSchizoaffective disorderBipolar disorderMental illnessAlcohol dependenceBetter alcohol use outcomesEffectiveness of naltrexoneIntensive psychosocial treatmentComorbid mental illnessUse of disulfiramAxis I DisordersSubstance use disordersSpectrum disorderActive medicationAlcohol use outcomesPharmacotherapeutic optionsSignificant morbidityMedication complianceClinical trialsI disordersPsychosocial treatmentsGeneral populationSpecific treatmentAlcohol abuseNaltrexone and Disulfiram in Patients with Alcohol Dependence and Comorbid Psychiatric Disorders
Petrakis IL, Poling J, Levinson C, Nich C, Carroll K, Rounsaville B, Group V. Naltrexone and Disulfiram in Patients with Alcohol Dependence and Comorbid Psychiatric Disorders. Biological Psychiatry 2005, 57: 1128-1137. PMID: 15866552, DOI: 10.1016/j.biopsych.2005.02.016.Peer-Reviewed Original ResearchConceptsPsychiatric disordersAlcohol dependenceVeterans Administration Outpatient ClinicAxis I psychiatric disordersComorbid psychiatric disordersUse of disulfiramTreatment of alcoholismEvent Monitoring SystemAlcohol-dependent individualsActive medicationAdverse eventsSecondary outcomesPrimary outcomeMedication complianceOutpatient clinicSignificant group differencesGGT levelsMedication studiesPsychiatric symptomsAlcohol consumptionNaltrexoneAlcohol cravingDrug AdministrationConsecutive weeksPlacebo
2004
Efficacy of Disulfiram and Cognitive Behavior Therapy in Cocaine-DependentOutpatients: A Randomized Placebo-Controlled Trial
Carroll KM, Fenton LR, Ball SA, Nich C, Frankforter TL, Shi J, Rounsaville BJ. Efficacy of Disulfiram and Cognitive Behavior Therapy in Cocaine-DependentOutpatients: A Randomized Placebo-Controlled Trial. JAMA Psychiatry 2004, 61: 264-272. PMID: 14993114, PMCID: PMC3675448, DOI: 10.1001/archpsyc.61.3.264.Peer-Reviewed Original ResearchConceptsCocaine useGeneral populationCocaine dependenceEfficacy of disulfiramUrine toxicology screenOutpatient substance abuse treatment programsBehavior therapyConcurrent alcohol useSubstance abuse treatment programsCurrent cocaine dependenceCognitive behavior therapyDisulfiram useRandomized PlaceboDisulfiram therapyMedication complianceToxicology screenIdentical capsulesEffective therapyPlaceboCocaine-dependent individualsSelf-reported frequencyPromising treatmentPlacebo conditionInterpersonal psychotherapyTherapy
2001
Targeting Behavioral Therapies to Enhance Naltrexone Treatment of Opioid Dependence: Efficacy of Contingency Management and Significant Other Involvement
Carroll KM, Ball SA, Nich C, O'Connor PG, Eagan DA, Frankforter TL, Triffleman EG, Shi J, Rounsaville BJ. Targeting Behavioral Therapies to Enhance Naltrexone Treatment of Opioid Dependence: Efficacy of Contingency Management and Significant Other Involvement. JAMA Psychiatry 2001, 58: 755-761. PMID: 11483141, PMCID: PMC3651594, DOI: 10.1001/archpsyc.58.8.755.Peer-Reviewed Original ResearchConceptsDrug-free urine specimensNaltrexone treatmentFamily counseling sessionsContingency managementOpioid dependenceTreatment retentionUrine specimensBehavioral therapyOpioid-dependent individualsCounseling sessionsDrug use outcomesSubstance abuse outcomesNaltrexone complianceNaltrexone therapyOpioid useAvailable pharmacotherapiesMedication complianceSpecific pharmacotherapySignificant improvementTherapyUse outcomesAbuse outcomesPrincipal outcomePharmacotherapyTreatment