2016
A Diagnostic Score for Insulin Resistance in Nondiabetic Patients with Ischemic Stroke or Transient Ischemic Attack
Xu J, Viscoli CM, Ford GA, Gorman M, Kernan WN, Investigators I. A Diagnostic Score for Insulin Resistance in Nondiabetic Patients with Ischemic Stroke or Transient Ischemic Attack. Journal Of Stroke And Cerebrovascular Diseases 2016, 25: 1705-1712. PMID: 27080156, PMCID: PMC5749402, DOI: 10.1016/j.jstrokecerebrovasdis.2016.03.043.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedArea Under CurveBiomarkersBlood GlucoseBlood PressureBody Mass IndexBrain IschemiaFemaleGlucose Metabolism DisordersHumansInsulinInsulin ResistanceIschemic Attack, TransientLipoproteins, HDLMaleMiddle AgedMultivariate AnalysisObesity, AbdominalPredictive Value of TestsRandomized Controlled Trials as TopicReproducibility of ResultsRisk FactorsROC CurveSex FactorsStrokeTriglyceridesWaist-Hip RatioConceptsTransient ischemic attackBody mass indexInsulin resistanceMultivariable regression analysisNondiabetic patientsIschemic strokeIschemic attackAbdominal obesityValidation cohortTriglyceride/high-density lipoprotein ratioHigh-density lipoprotein ratioRecent ischemic strokeHomeostasis model assessmentSystolic blood pressureLaboratory test valuesRegression analysisElevated waistHOMA-IRLipoprotein ratioBlood pressureMass indexMultivariable analysisStroke patientsHip ratioMale gender
2014
Pioglitazone for secondary prevention after ischemic stroke and transient ischemic attack: Rationale and design of the Insulin Resistance Intervention after Stroke Trial
Viscoli CM, Brass LM, Carolei A, Conwit R, Ford GA, Furie KL, Gorman M, Guarino PD, Inzucchi SE, Lovejoy AM, Parsons MW, Peduzzi PN, Ringleb PA, Schwartz GG, Spence JD, Tanne D, Young LH, Kernan WN, investigators I. Pioglitazone for secondary prevention after ischemic stroke and transient ischemic attack: Rationale and design of the Insulin Resistance Intervention after Stroke Trial. American Heart Journal 2014, 168: 823-829.e6. PMID: 25458644, PMCID: PMC4254508, DOI: 10.1016/j.ahj.2014.07.016.Peer-Reviewed Original ResearchMeSH KeywordsAdultCognition DisordersDose-Response Relationship, DrugDouble-Blind MethodFemaleHumansHypoglycemic AgentsInsulin ResistanceIschemic Attack, TransientMaleMiddle AgedMyocardial InfarctionPatient Outcome AssessmentPioglitazoneRisk AssessmentRisk FactorsSecondary PreventionStrokeSurvival AnalysisThiazolidinedionesConceptsTransient ischemic attackMyocardial infarctionIschemic attackVascular eventsIschemic strokeSecondary preventionIRIS trialInsulin resistanceHomeostasis model assessment-insulin resistanceModel assessment-insulin resistanceEffectiveness of pioglitazoneInsulin Resistance InterventionRecent ischemic strokeRecurrent vascular eventsAssessment-insulin resistanceIschemic vascular eventsAcute coronary syndromeInsulin-resistant patientsInsulin-sensitizing drugsEligible patientsIndex strokeNondiabetic patientsCardiovascular outcomesCause mortalityCoronary syndrome
2011
Boosting enrolment in clinical trials: validation of a regional network model
Kernan W, Viscoli C, Brass L, Amatangelo M, Birch A, Clark W, Conwit R, Furie K, Gorman M, Pesapane B, Kleindorfer D, Lovejoy A, Osborne J, Silliman S, Zweifler R, Horwitz R. Boosting enrolment in clinical trials: validation of a regional network model. Clinical Trials 2011, 8: 645-653. PMID: 21824978, PMCID: PMC3852692, DOI: 10.1177/1740774511414925.Peer-Reviewed Original ResearchConceptsClinical trialsTransient ischemic attackNames of patientsEligible patientsIschemic attackStroke preventionDrug adherenceStroke therapyActive surveillanceAverage monthly rateHome visitsPatientsHospitalTrial researchParticipant costsOutreach NetworkMultiple hospitalsTrialsStudy intervalNational InstituteEnrollmentMonthly rateStrokeParticipantsReproducible method
2008
Medical Students' Assessment of Education and Training in Women's Health and in Sex and Gender Differences
Henrich JB, Viscoli CM, Abraham GD. Medical Students' Assessment of Education and Training in Women's Health and in Sex and Gender Differences. Journal Of Women's Health 2008, 17: 815-827. PMID: 18537483, PMCID: PMC2942771, DOI: 10.1089/jwh.2007.0589.Peer-Reviewed Original ResearchConceptsAmerican Medical Women's AssociationFourth-year studentsMedical student assessmentAllopathic medical schoolsU.S. medical studentsStudent AssessmentSchool characteristicsYear studentsStudent sexMedical schoolsMedical studentsClinical skillsStudentsCurriculumModerate preparednessSchoolsOnline surveyPreparednessGender differencesWomen's healthTeachingEducationTopicSkillsRatingsDisagreement Between Students and Preceptors Regarding the Value of Teaching Behaviors for Ambulatory Care Settings
Kernan WN, Hershman W, Alper EJ, Lee MY, Viscoli CM, Perry JR, O'Connor PG. Disagreement Between Students and Preceptors Regarding the Value of Teaching Behaviors for Ambulatory Care Settings. Teaching And Learning In Medicine 2008, 20: 143-150. PMID: 18444201, DOI: 10.1080/10401330801991667.Peer-Reviewed Original ResearchConceptsPercentage of studentsTeaching behaviorsTeaching effectivenessU.S. schoolsClinical instructionMedical studentsStudentsPreceptorsDelegate responsibilityAmbulatory care settingsEarly negotiationsMutual satisfactionSchoolsInstructionLearningHistory takingAmbulatory careResponsibilityDiscussionRespondentsSatisfactionNegotiationsPurposeSettingTaking
2005
Major Risk Factors for Intracerebral Hemorrhage in the Young Are Modifiable
Feldmann E, Broderick JP, Kernan WN, Viscoli CM, Brass LM, Brott T, Morgenstern LB, Wilterdink JL, Horwitz RI. Major Risk Factors for Intracerebral Hemorrhage in the Young Are Modifiable. Stroke 2005, 36: 1881-1885. PMID: 16081867, DOI: 10.1161/01.str.0000177480.62341.6b.Peer-Reviewed Original ResearchConceptsPrimary intracerebral hemorrhageIntracerebral hemorrhageMajor risk factorRisk factorsHemorrhagic strokeCase subjectsIndependent risk factorHistory of strokeCurrent cigarette smokingCase-control studyType of strokeMultivariate regression analysisCigarette smokingStroke ProjectControl subjectsStructural lesionsArteriovenous malformationsBrain lesionsEligibility criteriaStrokeYoung menAlcoholic drinksFurther studiesHemorrhageMenopause
2003
Major Risk Factors for Aneurysmal Subarachnoid Hemorrhage in the Young Are Modifiable
Broderick JP, Viscoli CM, Brott T, Kernan WN, Brass LM, Feldmann E, Morgenstern LB, Wilterdink JL, Horwitz RI. Major Risk Factors for Aneurysmal Subarachnoid Hemorrhage in the Young Are Modifiable. Stroke 2003, 34: 1375-1381. PMID: 12764233, DOI: 10.1161/01.str.0000074572.91827.f4.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge DistributionBody Mass IndexCase-Control StudiesCocaine-Related DisordersCohort StudiesComorbidityCooperative BehaviorFemaleHumansHypertensionLogistic ModelsMaleMiddle AgedOdds RatioPhenylpropanolamineRisk FactorsSex DistributionSmokingStrokeSubarachnoid HemorrhageThinnessUnited StatesConceptsAneurysmal subarachnoid hemorrhageSubarachnoid hemorrhageRisk factorsLower body mass indexIndependent risk factorCurrent cigarette smokersPrevalent risk factorsBody mass indexMajor risk factorCase-control studyYears of ageRandom digit dialingWarrants further studyHemorrhagic strokeIntracerebral hemorrhageCigarette smokersMass indexPreventable diseaseWomen 18Multivariable modelFamily historyCase subjectsAssociation of caffeineCocaine useHemorrhageUse of Ephedra-containing products and risk for hemorrhagic stroke
Morgenstern LB, Viscoli CM, Kernan WN, Brass LM, Broderick JP, Feldmann E, Wilterdink JL, Brott T, Horwitz RI. Use of Ephedra-containing products and risk for hemorrhagic stroke. Neurology 2003, 60: 132-135. PMID: 12525737, DOI: 10.1212/01.wnl.0000042092.20411.5b.Peer-Reviewed Original Research
1997
Functional recovery after myocardial infarction in men: the independent effects of social class.
Ickovics JR, Viscoli CM, Horwitz RI. Functional recovery after myocardial infarction in men: the independent effects of social class. Annals Of Internal Medicine 1997, 127: 518-25. PMID: 9313019, DOI: 10.7326/0003-4819-127-7-199710010-00003.Peer-Reviewed Original ResearchConceptsBeta-Blocker Heart Attack TrialHeart Attack TrialMyocardial infarctionFunctional recoveryAttack TrialNew York Heart Association functional classPsychosocial factorsYork Heart Association functional classFunctional status 1 yearDouble-blind clinical trialCardiovascular-related illnessesPertinent prognostic factorsAcute myocardial infarctionIndependent effectsYears of agePrimary outcomePrognostic factorsClinical outcomesFunctional statusProspective dataClinical trialsInfarctionHigher social classMen 29Baseline assessment
1993
Beta-blockers after myocardial infarction: influence of first-year clinical course on long-term effectiveness.
Viscoli CM, Horwitz RI, Singer BH. Beta-blockers after myocardial infarction: influence of first-year clinical course on long-term effectiveness. Annals Of Internal Medicine 1993, 118: 99-105. PMID: 8416325, DOI: 10.7326/0003-4819-118-2-199301150-00004.Peer-Reviewed Original ResearchConceptsBeta-blocker therapyClinical courseVital statusMyocardial infarctionLong-term beneficial effectsPlacebo-controlled trialRecurrent ischemic eventsInitiation of therapyCongestive heart failureHeart Attack TrialLong-term therapeutic benefitHeterogeneous clinical courseYears of ageLong-term effectivenessEligible patientsSevere comorbiditiesBeta blockersIschemic eventsHeart failureTrial entryAttack TrialClinical centersSubsequent riskWomen 30High risk
1990
Treatment adherence and risk of death after a myocardial infarction
Horwitz RI, Viscoli CM, Donaldson R, Murray C, Ransohoff D, Horwitz R, Berkman L, Horwitz S, Ransohoff D, Sindelar J. Treatment adherence and risk of death after a myocardial infarction. The Lancet 1990, 336: 542-545. PMID: 1975045, DOI: 10.1016/0140-6736(90)92095-y.Peer-Reviewed Original ResearchConceptsRisk of deathTreatment adherenceMyocardial infarctionPoor adherersBeta-Blocker Heart Attack TrialPost-infarction mortalityHeart Attack TrialGood adherersTreatment regimenAttack TrialClinical severitySociodemographic featuresInfarctionAdherersAdherenceDeathMortalityRiskSeverityPlaceboRegimenSmokingPatientsPropranololTrialsDifferences between women and men in survival after myocardial infarction. Biology or methodology?
Fiebach NH, Viscoli CM, Horwitz RI. Differences between women and men in survival after myocardial infarction. Biology or methodology? JAMA 1990, 263: 1092-6. PMID: 2299781, DOI: 10.1001/jama.263.8.1092.Peer-Reviewed Original ResearchConceptsMyocardial infarctionMortality rateHospital survivorsRisk factorsPrevious heart failureHospital mortality rateRetrospective cohort studyIndependent risk factorObserved mortality rateHospital deathCohort studyMultivariate adjustmentHeart failureVentricular functionBaseline differencesSubsequent mortalityInfarctionMortalityWomenMenImpact of genderSurvivorsSurvivalHypertensionGender