2022
Differences in the management of thyroid nodules in children and adolescents as compared to adults
Goldfarb M, Dinauer C. Differences in the management of thyroid nodules in children and adolescents as compared to adults. Current Opinion In Endocrinology Diabetes And Obesity 2022, 29: 466-473. PMID: 35777975, DOI: 10.1097/med.0000000000000754.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPediatric thyroid nodulesThyroid nodulesFine-needle aspiration biopsyRisk of malignancyRisk stratification systemSpecific risk factorsAppropriate imaging modalityNeedle aspiration biopsyCertain genetic syndromesYounger patientsNonoperative approachClinical managementRadiofrequency ablationRisk factorsPretest probabilityAspiration biopsyMiRNA classifierSpecific molecular testsMolecular testingUltrasound characteristicsAge groupsGenetic syndromesClinical usePatientsBenign nodulesTreatment of hypothyroidism in infants, children and adolescents
Rodriguez L, Dinauer C, Francis G. Treatment of hypothyroidism in infants, children and adolescents. Trends In Endocrinology And Metabolism 2022, 33: 522-532. PMID: 35537910, DOI: 10.1016/j.tem.2022.04.007.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsTreatment of hypothyroidismLow birth weightBirth weightCongenital hypothyroidismNormal thyrotropin levelsAmerican Thyroid AssociationSubset of childrenSubclinical hypothyroidismThyrotropin levelsTreatment guidelinesThyroid AssociationHypothyroidismTreatmentChildrenDiagnosisPreferred methodLevothyroxineGeneral consensusObesityInfantsSyndrome
2021
Management of Pediatric Graves Disease
Quintanilla-Dieck L, Khalatbari HK, Dinauer CA, Rastatter JC, Chelius DC, Katowitz WR, Shindo ML, Parisi MT, Kazahaya K. Management of Pediatric Graves Disease. JAMA Otolaryngology - Head & Neck Surgery 2021, 147: 1110-1118. PMID: 34647991, DOI: 10.1001/jamaoto.2021.2715.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsGraves' diseaseClinical presenting signsPediatric Graves' diseaseSustained remission rateRadioactive iodine therapyFirst-line treatmentSpecific clinical characteristicsMultidisciplinary approachIodine therapyRemission rateClinical characteristicsDefinitive treatmentMedical therapyPediatric patientsPresenting signMedical managementPediatric populationAntithyroid drugsTherapeutic optionsCertain patientsTreatment optionsOptimal treatmentThyroid ultrasonographyPediatric expertsNuclear medicine
2020
Pediatric differentiated thyroid carcinoma: An update from the APSA Cancer Committee
Christison-Lagay ER, Baertschiger RM, Dinauer C, Francis G, Malek M, Lautz T, Aldrink J, Grant C, Rhee D, Ehrlich P, Dasgupta R, Abdessalam S, Committee O. Pediatric differentiated thyroid carcinoma: An update from the APSA Cancer Committee. Journal Of Pediatric Surgery 2020, 55: 2273-2283. PMID: 32553450, DOI: 10.1016/j.jpedsurg.2020.05.003.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsThyroid cancerPediatric DTCAPSA Cancer CommitteeSurgical therapeutic approachUnresectable progressive diseaseLymph node basinCornerstone of treatmentAutoimmune thyroid diseaseLong-term recurrenceFine-needle aspirationNode basinTotal thyroidectomyProgressive diseaseSurgical resectionRadiological featuresSurvival outcomesCancer CommitteeThyroid diseaseTreatment strategiesFamily historyTreatment decisionsNeedle aspirationTherapeutic approachesThyroid carcinomaIodine deficiencyLarge-scale second-hit AIP deletion causing a pediatric growth hormone-secreting pituitary adenoma: Case report and review of literature
Gummadavelli A, Dinauer C, McGuone D, Vining EM, Erson-Omay EZ, Omay SB. Large-scale second-hit AIP deletion causing a pediatric growth hormone-secreting pituitary adenoma: Case report and review of literature. Journal Of Clinical Neuroscience 2020, 78: 420-422. PMID: 32336638, DOI: 10.1016/j.jocn.2020.04.103.Peer-Reviewed Original ResearchRecurrence and Complications in Pediatric and Adolescent Papillary Thyroid Cancer in a High-Volume Practice
Rubinstein JC, Herrick-Reynolds K, Dinauer C, Morotti R, Solomon D, Callender GG, Christison-Lagay ER. Recurrence and Complications in Pediatric and Adolescent Papillary Thyroid Cancer in a High-Volume Practice. Journal Of Surgical Research 2020, 249: 58-66. PMID: 31923715, DOI: 10.1016/j.jss.2019.12.002.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge FactorsChildFemaleFollow-Up StudiesHospitals, High-VolumeHumansLymph NodesLymphatic MetastasisMaleNeoplasm Recurrence, LocalPostoperative ComplicationsPrognosisRetrospective StudiesRisk AssessmentRisk FactorsSurvival AnalysisThyroid Cancer, PapillaryThyroid GlandThyroid NeoplasmsThyroidectomyTreatment OutcomeYoung AdultConceptsPediatric papillary thyroid cancerLateral neck diseaseNeck diseasePapillary thyroid cancerNode involvementThyroid cancerExact testLymph node involvementCentral neck dissectionExtent of diseasePredictors of recurrenceRetrospective case seriesNon-Caucasian raceCox proportional hazardsLateral node involvementHigh-volume practiceFisher's exact testDisease recurrenceLymphovascular invasionMedian ageNeck dissectionCase seriesIndependent predictorsRetrospective reviewTumor size
2018
Lymph node ratio predicts recurrence in pediatric papillary thyroid cancer
Rubinstein JC, Dinauer C, Herrick-Reynolds K, Morotti R, Callender GG, Christison-Lagay ER. Lymph node ratio predicts recurrence in pediatric papillary thyroid cancer. Journal Of Pediatric Surgery 2018, 54: 129-132. PMID: 30361076, DOI: 10.1016/j.jpedsurg.2018.10.010.Peer-Reviewed Original ResearchConceptsPapillary thyroid cancerPediatric patientsTotal thyroidectomyNeck dissectionThyroid cancerN1b papillary thyroid cancerPediatric papillary thyroid cancerProphylactic central neck dissectionRegional lymph node metastasisCentral neck dissectionRetrospective case seriesLymph node metastasisRadical neck dissectionTime of presentationLikelihood of recurrenceTime of operationMedian ageMedian durationMetastatic LNsNode metastasisCase seriesPediatric populationPrognostic predictorSingle institutionSingle recurrence
2017
Pathologic Characteristics, Natural History, and Prognostic Implications of BRAFV600E Mutation in Pediatric Papillary Thyroid Carcinoma
Hardee S, Prasad ML, Hui P, Dinauer CA, Morotti RA. Pathologic Characteristics, Natural History, and Prognostic Implications of BRAFV600E Mutation in Pediatric Papillary Thyroid Carcinoma. Pediatric And Developmental Pathology 2017, 20: 206-212. PMID: 28521635, DOI: 10.1177/1093526616689628.Peer-Reviewed Original ResearchConceptsPapillary thyroid cancerPediatric papillary thyroid cancerPrognostic implicationsPediatric papillary thyroid carcinomaNegative casesBRAF-negative casesBRAF-negative patientsBRAF-positive casesTertiary medical centerAggressive clinical coursePapillary thyroid carcinomaSurgical pathology diagnosisCommon genetic aberrationsNegative patientsAggressive courseClinical coursePathologic characteristicsCase seriesClinical outcomesRetrospective reviewAggressive featuresPediatric casesRecurrence rateRetrospective studySingle institution
2016
NTRK fusion oncogenes in pediatric papillary thyroid carcinoma in northeast United States
Prasad ML, Vyas M, Horne MJ, Virk RK, Morotti R, Liu Z, Tallini G, Nikiforova MN, Christison-Lagay ER, Udelsman R, Dinauer CA, Nikiforov YE. NTRK fusion oncogenes in pediatric papillary thyroid carcinoma in northeast United States. Cancer 2016, 122: 1097-1107. PMID: 26784937, DOI: 10.1002/cncr.29887.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentCarcinomaCarcinoma, PapillaryChildDNA Mutational AnalysisFemaleHigh-Throughput Nucleotide SequencingHumansMaleMutationNew EnglandNuclear Pore Complex ProteinsOncogene Proteins, FusionProto-Oncogene MasProto-Oncogene ProteinsProto-Oncogene Proteins B-rafProto-Oncogene Proteins c-etsProto-Oncogene Proteins c-retReceptor, trkAReceptor, trkCRepressor ProteinsReverse Transcriptase Polymerase Chain ReactionThyroid Cancer, PapillaryThyroid Neoplasms
2015
Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer
Francis GL, Waguespack SG, Bauer AJ, Angelos P, Benvenga S, Cerutti JM, Dinauer CA, Hamilton J, Hay ID, Luster M, Parisi MT, Rachmiel M, Thompson GB, Yamashita S. Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid 2015, 25: 716-759. PMID: 25900731, PMCID: PMC4854274, DOI: 10.1089/thy.2014.0460.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsDifferentiated thyroid cancerAmerican Thyroid AssociationThyroid cancerThyroid nodulesUnited States Preventive Services Task ForceFine needle aspiration cytologyRadioactive iodine therapyLong-term outcomesManagement of childrenFollicular thyroid cancerTask ForceScientific evidenceYears of ageLong-term harmIodine therapyPostoperative stagingAggressive treatmentThyrotropin suppressionClinical presentationPreoperative stagingSurgical managementOptimal careThyroid AssociationAspiration cytologyHigh riskC-Cell Neoplasia in Asymptomatic Carriers of RET Mutation in Extracellular Cysteine-Rich and Intracellular Tyrosine Kinase Domain
Abi-Raad R, Virk RK, Dinauer CA, Prasad A, Morotti RA, Breuer CK, Sosa JA, Udelsman R, Rivkees SA, Prasad ML. C-Cell Neoplasia in Asymptomatic Carriers of RET Mutation in Extracellular Cysteine-Rich and Intracellular Tyrosine Kinase Domain. Human Pathology 2015, 46: 1121-1128. PMID: 26033033, DOI: 10.1016/j.humpath.2015.04.011.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultCarcinoma, NeuroendocrineChildChild, PreschoolFemaleGenetic Predisposition to DiseaseGerm-Line MutationHeterozygoteHumansInfantMaleMiddle AgedMultiple Endocrine NeoplasiaProtein Structure, TertiaryProto-Oncogene MasProto-Oncogene Proteins c-retThyroid NeoplasmsYoung AdultConceptsMedullary thyroid carcinomaMultiple endocrine neoplasia type 2C-cell hyperplasiaAsymptomatic carriersC-cell neoplasiaRET mutationsMTC familiesHigh-risk RET mutationsIntracellular tyrosine kinase domainTyrosine kinase domainC-cell diseaseC-cell pathologyLymph node metastasisCodon 918 mutationYounger median ageReceptor tyrosine kinase proteinTotal thyroidectomyProgressive diseaseMedian ageNode metastasisThyroid carcinomaType 2Germline mutationsTyrosine kinase proteinFormer group
2011
The Treatment of Differentiated Thyroid Cancer in Children: Emphasis on Surgical Approach and Radioactive Iodine Therapy
Rivkees SA, Mazzaferri EL, Verburg FA, Reiners C, Luster M, Breuer CK, Dinauer CA, Udelsman R. The Treatment of Differentiated Thyroid Cancer in Children: Emphasis on Surgical Approach and Radioactive Iodine Therapy. Endocrine Reviews 2011, 32: 798-826. PMID: 21880704, PMCID: PMC3591676, DOI: 10.1210/er.2011-0011.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsDifferentiated thyroid cancerPediatric thyroid cancerRadioactive iodine therapyThyroid cancerIodine therapyCentral compartment lymph node dissectionHigh-volume thyroid surgeonPediatric differentiated thyroid cancerLymph node dissectionRisk of recurrenceHigh recurrence rateFollicular thyroid cancerBest care optionsDTC managementNode dissectionTotal thyroidectomyExcellent prognosisProspective trialRemnant ablationInitial diagnosisRandomized trialsRecurrence rateResidual diseaseSurgical approachThyroid surgeons
2008
Differentiated thyroid cancer in children: diagnosis and management
Dinauer CA, Breuer C, Rivkees SA. Differentiated thyroid cancer in children: diagnosis and management. Current Opinion In Oncology 2008, 20: 59-65. PMID: 18043257, DOI: 10.1097/cco.0b013e3282f30220.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsDifferentiated thyroid cancerThyroid cancerOptimal treatmentDifferentiated thyroid cancer treatmentPediatric thyroid cancerLymph node dissectionTime of diagnosisLarge case seriesCommon endocrine malignancyThyroid cancer treatmentAdvanced diseaseTotal thyroidectomyAdult patientsRemnant ablationYounger patientsPediatric patientsCase seriesSurgical approachFavorable outcomeEndocrine malignancyUnusual diseaseClinical approachRadioactive iodineCancerPatients
2007
Thyroid Cancer in Children
Dinauer C, Francis GL. Thyroid Cancer in Children. Endocrinology And Metabolism Clinics Of North America 2007, 36: 779-806. PMID: 17673128, DOI: 10.1016/j.ecl.2007.04.002.ChaptersConceptsDetectable serum thyroglobulinThyroid cancerSerum thyroglobulinNegative whole-body scanNegative imaging studiesManagement of childrenChildhood thyroid cancerRobust immune responseWhole-body scanYears of ageHigh-risk categoryGrowth factor expression patternsRecurrent diseaseUncommon tumorCurrent guidelinesImmune responseHigh riskImaging studiesCancerUnique subsetGenetic mutationsLimited dataChildrenPatientsThyroglobulinAn Optimal Treatment for Pediatric Graves’ Disease Is Radioiodine
Rivkees SA, Dinauer C. An Optimal Treatment for Pediatric Graves’ Disease Is Radioiodine. The Journal Of Clinical Endocrinology & Metabolism 2007, 92: 797-800. PMID: 17341574, DOI: 10.1210/jc.2006-1239.Commentaries, Editorials and LettersConceptsGraves' diseaseAntithyroid medicationRadioactive iodineThyroid cancerSide effectsLong-term adverse side effectsPediatric Graves' diseaseAcute side effectsLong-term remissionTreatment of hyperthyroidismAdverse side effectsMajority of childrenCurative therapyThyroid irradiationPediatric populationSpontaneous remissionOptimal treatmentSufficient dosesDefinite riskTreatment approachesMedicationsEffective cureDiseaseRemissionChildren
2004
The MACIS Score Predicts the Clinical Course of Papillary Thyroid Carcinoma in Children and Adolescents
Powers PA, Dinauer CA, Tuttle RM, Francis GL. The MACIS Score Predicts the Clinical Course of Papillary Thyroid Carcinoma in Children and Adolescents. Journal Of Pediatric Endocrinology And Metabolism 2004, 17: 339-344. PMID: 15112910, DOI: 10.1515/jpem.2004.17.3.339.Peer-Reviewed Original Research
2003
Treatment of Recurrent Papillary Thyroid Carcinoma in Children and Adolescents
Powers PA, Dinauer CA, Tuttle RM, Francis GL. Treatment of Recurrent Papillary Thyroid Carcinoma in Children and Adolescents. Journal Of Pediatric Endocrinology And Metabolism 2003, 16: 1033-1040. PMID: 14513881, DOI: 10.1515/jpem.2003.16.7.1033.Peer-Reviewed Original ResearchConceptsRecurrent papillary thyroid carcinomaPapillary thyroid carcinomaThyroid carcinomaYears of ageThird remissionCervical nodesPersistent diseaseClinical coursePoor prognosisSecond recurrenceHigh mortalityRemissionChildrenCarcinomaRecurrenceMortalityTreatmentAdultsPrevious dataPatientsPrognosisDiseaseTumor Size and Extent of Disease at Diagnosis Predict the Response to Initial Therapy for Papillary Thyroid Carcinoma in Children and Adolescents
Powers PA, Dinauer CA, Tuttle RM, Robie DK, McClellan DR, Francis GL. Tumor Size and Extent of Disease at Diagnosis Predict the Response to Initial Therapy for Papillary Thyroid Carcinoma in Children and Adolescents. Journal Of Pediatric Endocrinology And Metabolism 2003, 16: 693-702. PMID: 12880118, DOI: 10.1515/jpem.2003.16.5.693.Peer-Reviewed Original ResearchConceptsPapillary thyroid carcinomaExtent of diseaseLarger tumor sizeTumor sizeExtensive diseaseInitial treatmentThyroid carcinomaRadioactive iodine treatmentClass IV patientsInitial therapyFirst remissionIV patientsPersistent diseaseMultifocal diseasePatientsClass IIIRemissionClass IIIodine treatmentDiseaseClass IDiagnosisTreatmentCarcinomaChildren
2002
Intense Expression of the B7-2 Antigen Presentation Coactivator Is an Unfavorable Prognostic Indicator for Differentiated Thyroid Carcinoma of Children and Adolescents
Shah R, Banks K, Patel A, Dogra S, Terrell R, Powers PA, Fenton C, Dinauer CA, Tuttle RM, Francis GL. Intense Expression of the B7-2 Antigen Presentation Coactivator Is an Unfavorable Prognostic Indicator for Differentiated Thyroid Carcinoma of Children and Adolescents. The Journal Of Clinical Endocrinology & Metabolism 2002, 87: 4391-4397. PMID: 12213904, DOI: 10.1210/jc.2002-011262.Peer-Reviewed Original ResearchConceptsB7-2 expressionThyroid carcinomaLymphocytic infiltrationB7-1B7-2Immune responseAdjacent thyroidImproved disease-free survivalDisease-free survivalTumor-associated lymphocytesDifferentiated thyroid carcinomaProbability of remissionUnfavorable prognostic indicatorB7-1 expressionFollicular thyroid carcinomaLong-term survivalHigh-power fieldBenign thyroid lesionsPrognostic indicatorThyroid diseaseAntigen presentationBenign tumorsMalignant tumorsCarcinomaThyroid lesionsNitrotyrosine, inducible nitric oxide synthase (iNOS), and endothelial nitric oxide synthase (eNOS) are increased in thyroid tumors from children and adolescents
Patel A, Fenton C, Terrell R, Powers P, Dinauer C, Tuttle R, Francis G. Nitrotyrosine, inducible nitric oxide synthase (iNOS), and endothelial nitric oxide synthase (eNOS) are increased in thyroid tumors from children and adolescents. Journal Of Endocrinological Investigation 2002, 25: 675-683. PMID: 12240898, DOI: 10.1007/bf03345100.Peer-Reviewed Original ResearchConceptsInducible nitric oxide synthaseEndothelial nitric oxide synthaseFollicular thyroid carcinomaPapillary thyroid carcinomaNitric oxide synthaseAutoimmune lesionsBenign adenomasMultinodular goiterNitric oxideThyroid tumorsNormal thyroidOxide synthaseThyroid carcinomaAutoimmune thyroid diseaseNeuronal NO synthaseVascular endothelial growth factorHigh-power field