2021
Management of Pediatric Graves Disease
Quintanilla-Dieck L, Khalatbari HK, Dinauer CA, Rastatter JC, Chelius DC, Katowitz WR, Shindo ML, Parisi MT, Kazahaya K. Management of Pediatric Graves Disease. JAMA Otolaryngology - Head & Neck Surgery 2021, 147: 1110-1118. PMID: 34647991, DOI: 10.1001/jamaoto.2021.2715.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsGraves' diseaseClinical presenting signsPediatric Graves' diseaseSustained remission rateRadioactive iodine therapyFirst-line treatmentSpecific clinical characteristicsMultidisciplinary approachIodine therapyRemission rateClinical characteristicsDefinitive treatmentMedical therapyPediatric patientsPresenting signMedical managementPediatric populationAntithyroid drugsTherapeutic optionsCertain patientsTreatment optionsOptimal treatmentThyroid ultrasonographyPediatric expertsNuclear medicine
2020
Pediatric differentiated thyroid carcinoma: An update from the APSA Cancer Committee
Christison-Lagay ER, Baertschiger RM, Dinauer C, Francis G, Malek M, Lautz T, Aldrink J, Grant C, Rhee D, Ehrlich P, Dasgupta R, Abdessalam S, Committee O. Pediatric differentiated thyroid carcinoma: An update from the APSA Cancer Committee. Journal Of Pediatric Surgery 2020, 55: 2273-2283. PMID: 32553450, DOI: 10.1016/j.jpedsurg.2020.05.003.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAdolescentChildChild, PreschoolFemaleHumansNeoplasm Recurrence, LocalThyroid NeoplasmsThyroid NoduleThyroidectomyConceptsThyroid cancerPediatric DTCAPSA Cancer CommitteeSurgical therapeutic approachUnresectable progressive diseaseLymph node basinCornerstone of treatmentAutoimmune thyroid diseaseLong-term recurrenceFine-needle aspirationNode basinTotal thyroidectomyProgressive diseaseSurgical resectionRadiological featuresSurvival outcomesCancer CommitteeThyroid diseaseTreatment strategiesFamily historyTreatment decisionsNeedle aspirationTherapeutic approachesThyroid carcinomaIodine deficiencyRecurrence and Complications in Pediatric and Adolescent Papillary Thyroid Cancer in a High-Volume Practice
Rubinstein JC, Herrick-Reynolds K, Dinauer C, Morotti R, Solomon D, Callender GG, Christison-Lagay ER. Recurrence and Complications in Pediatric and Adolescent Papillary Thyroid Cancer in a High-Volume Practice. Journal Of Surgical Research 2020, 249: 58-66. PMID: 31923715, DOI: 10.1016/j.jss.2019.12.002.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge FactorsChildFemaleFollow-Up StudiesHospitals, High-VolumeHumansLymph NodesLymphatic MetastasisMaleNeoplasm Recurrence, LocalPostoperative ComplicationsPrognosisRetrospective StudiesRisk AssessmentRisk FactorsSurvival AnalysisThyroid Cancer, PapillaryThyroid GlandThyroid NeoplasmsThyroidectomyTreatment OutcomeYoung AdultConceptsPediatric papillary thyroid cancerLateral neck diseaseNeck diseasePapillary thyroid cancerNode involvementThyroid cancerExact testLymph node involvementCentral neck dissectionExtent of diseasePredictors of recurrenceRetrospective case seriesNon-Caucasian raceCox proportional hazardsLateral node involvementHigh-volume practiceFisher's exact testDisease recurrenceLymphovascular invasionMedian ageNeck dissectionCase seriesIndependent predictorsRetrospective reviewTumor size
2018
Lymph node ratio predicts recurrence in pediatric papillary thyroid cancer
Rubinstein JC, Dinauer C, Herrick-Reynolds K, Morotti R, Callender GG, Christison-Lagay ER. Lymph node ratio predicts recurrence in pediatric papillary thyroid cancer. Journal Of Pediatric Surgery 2018, 54: 129-132. PMID: 30361076, DOI: 10.1016/j.jpedsurg.2018.10.010.Peer-Reviewed Original ResearchConceptsPapillary thyroid cancerPediatric patientsTotal thyroidectomyNeck dissectionThyroid cancerN1b papillary thyroid cancerPediatric papillary thyroid cancerProphylactic central neck dissectionRegional lymph node metastasisCentral neck dissectionRetrospective case seriesLymph node metastasisRadical neck dissectionTime of presentationLikelihood of recurrenceTime of operationMedian ageMedian durationMetastatic LNsNode metastasisCase seriesPediatric populationPrognostic predictorSingle institutionSingle recurrence
2017
Pathologic Characteristics, Natural History, and Prognostic Implications of BRAFV600E Mutation in Pediatric Papillary Thyroid Carcinoma
Hardee S, Prasad ML, Hui P, Dinauer CA, Morotti RA. Pathologic Characteristics, Natural History, and Prognostic Implications of BRAFV600E Mutation in Pediatric Papillary Thyroid Carcinoma. Pediatric And Developmental Pathology 2017, 20: 206-212. PMID: 28521635, DOI: 10.1177/1093526616689628.Peer-Reviewed Original ResearchConceptsPapillary thyroid cancerPediatric papillary thyroid cancerPrognostic implicationsPediatric papillary thyroid carcinomaNegative casesBRAF-negative casesBRAF-negative patientsBRAF-positive casesTertiary medical centerAggressive clinical coursePapillary thyroid carcinomaSurgical pathology diagnosisCommon genetic aberrationsNegative patientsAggressive courseClinical coursePathologic characteristicsCase seriesClinical outcomesRetrospective reviewAggressive featuresPediatric casesRecurrence rateRetrospective studySingle institution
2011
The Treatment of Differentiated Thyroid Cancer in Children: Emphasis on Surgical Approach and Radioactive Iodine Therapy
Rivkees SA, Mazzaferri EL, Verburg FA, Reiners C, Luster M, Breuer CK, Dinauer CA, Udelsman R. The Treatment of Differentiated Thyroid Cancer in Children: Emphasis on Surgical Approach and Radioactive Iodine Therapy. Endocrine Reviews 2011, 32: 798-826. PMID: 21880704, PMCID: PMC3591676, DOI: 10.1210/er.2011-0011.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsDifferentiated thyroid cancerPediatric thyroid cancerRadioactive iodine therapyThyroid cancerIodine therapyCentral compartment lymph node dissectionHigh-volume thyroid surgeonPediatric differentiated thyroid cancerLymph node dissectionRisk of recurrenceHigh recurrence rateFollicular thyroid cancerBest care optionsDTC managementNode dissectionTotal thyroidectomyExcellent prognosisProspective trialRemnant ablationInitial diagnosisRandomized trialsRecurrence rateResidual diseaseSurgical approachThyroid surgeons
2008
Differentiated thyroid cancer in children: diagnosis and management
Dinauer CA, Breuer C, Rivkees SA. Differentiated thyroid cancer in children: diagnosis and management. Current Opinion In Oncology 2008, 20: 59-65. PMID: 18043257, DOI: 10.1097/cco.0b013e3282f30220.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsChildHumansIodine RadioisotopesModels, BiologicalNeoplasm StagingPrognosisThyroid NeoplasmsThyroidectomyConceptsDifferentiated thyroid cancerThyroid cancerOptimal treatmentDifferentiated thyroid cancer treatmentPediatric thyroid cancerLymph node dissectionTime of diagnosisLarge case seriesCommon endocrine malignancyThyroid cancer treatmentAdvanced diseaseTotal thyroidectomyAdult patientsRemnant ablationYounger patientsPediatric patientsCase seriesSurgical approachFavorable outcomeEndocrine malignancyUnusual diseaseClinical approachRadioactive iodineCancerPatients
2007
Thyroid Cancer in Children
Dinauer C, Francis GL. Thyroid Cancer in Children. Endocrinology And Metabolism Clinics Of North America 2007, 36: 779-806. PMID: 17673128, DOI: 10.1016/j.ecl.2007.04.002.ChaptersConceptsDetectable serum thyroglobulinThyroid cancerSerum thyroglobulinNegative whole-body scanNegative imaging studiesManagement of childrenChildhood thyroid cancerRobust immune responseWhole-body scanYears of ageHigh-risk categoryGrowth factor expression patternsRecurrent diseaseUncommon tumorCurrent guidelinesImmune responseHigh riskImaging studiesCancerUnique subsetGenetic mutationsLimited dataChildrenPatientsThyroglobulin
2003
Tumor Size and Extent of Disease at Diagnosis Predict the Response to Initial Therapy for Papillary Thyroid Carcinoma in Children and Adolescents
Powers PA, Dinauer CA, Tuttle RM, Robie DK, McClellan DR, Francis GL. Tumor Size and Extent of Disease at Diagnosis Predict the Response to Initial Therapy for Papillary Thyroid Carcinoma in Children and Adolescents. Journal Of Pediatric Endocrinology And Metabolism 2003, 16: 693-702. PMID: 12880118, DOI: 10.1515/jpem.2003.16.5.693.Peer-Reviewed Original ResearchConceptsPapillary thyroid carcinomaExtent of diseaseLarger tumor sizeTumor sizeExtensive diseaseInitial treatmentThyroid carcinomaRadioactive iodine treatmentClass IV patientsInitial therapyFirst remissionIV patientsPersistent diseaseMultifocal diseasePatientsClass IIIRemissionClass IIIodine treatmentDiseaseClass IDiagnosisTreatmentCarcinomaChildren
1999
Extensive surgery improves recurrence-free survival for children and young patients with class I papillary thyroid carcinoma
Dinauer C, Tuttle R, Robie D, McClellan D, Francis G. Extensive surgery improves recurrence-free survival for children and young patients with class I papillary thyroid carcinoma. Journal Of Pediatric Surgery 1999, 34: 1799-1804. PMID: 10626858, DOI: 10.1016/s0022-3468(99)90316-0.Peer-Reviewed Original ResearchConceptsPapillary thyroid cancerRisk of complicationsExtensive surgeryRadioactive iodineHigh riskThyroid hormonesRecurrent papillary thyroid cancerIncidence of complicationsRecurrence-free survivalRisk of recurrenceYears of agePapillary thyroid carcinomaInitial surgeryPermanent hypoparathyroidismSubtotal thyroidectomyTotal thyroidectomyAdjunctive therapySurgical complicationsSurgical groupYounger patientsMultifocal diseaseMultifocal tumorsContralateral lobeOptimal treatmentThyroid cancer