2020
A Comparison of the Differences Between Dutch and American Thyroid Association Guidelines for the Management of Pediatric Thyroid Cancer
Dinauer C. A Comparison of the Differences Between Dutch and American Thyroid Association Guidelines for the Management of Pediatric Thyroid Cancer. Clinical Thyroidology 2020, 32: 525-528. DOI: 10.1089/ct.2020;32.525-528.Commentaries, Editorials and LettersCytomorphologic features of thyroid disease in patients with DICER1 mutations: A report of cytology–histopathology correlation in 7 patients
Darbinyan A, Morotti R, Cai G, Prasad ML, Christison‐Lagay E, Dinauer C, Adeniran AJ. Cytomorphologic features of thyroid disease in patients with DICER1 mutations: A report of cytology–histopathology correlation in 7 patients. Cancer Cytopathology 2020, 128: 746-756. PMID: 32897650, DOI: 10.1002/cncy.22329.Peer-Reviewed Original ResearchConceptsDICER1 mutationsThyroid diseaseThyroid carcinomaScreening of patientsFine-needle aspiration samplesMonitoring of patientsDiagnostic cytologic featuresPapillary thyroid carcinomaGermline DICER1 mutationsThyroid fine-needle aspiration samplesFNA evaluationUndetermined significanceDifferent somatic variantsThyroid cancerScant colloidNeoplastic lesionsHistopathological analysisCytomorphologic featuresDICER1 syndromeModerate cellularityCytologic featuresFollicular carcinomaFollicular lesionsInconspicuous nucleoliFollicular neoplasmTotal Thyroidectomy Remains Appropriate as Initial Treatment for Children with Papillary Thyroid Cancer That Frequently Harbors Occult Bilateral Disease
Dinauer C. Total Thyroidectomy Remains Appropriate as Initial Treatment for Children with Papillary Thyroid Cancer That Frequently Harbors Occult Bilateral Disease. Clinical Thyroidology 2020, 32: 333-336. DOI: 10.1089/ct.2020;32.333-336.Commentaries, Editorials and LettersPediatric differentiated thyroid carcinoma: An update from the APSA Cancer Committee
Christison-Lagay ER, Baertschiger RM, Dinauer C, Francis G, Malek M, Lautz T, Aldrink J, Grant C, Rhee D, Ehrlich P, Dasgupta R, Abdessalam S, Committee O. Pediatric differentiated thyroid carcinoma: An update from the APSA Cancer Committee. Journal Of Pediatric Surgery 2020, 55: 2273-2283. PMID: 32553450, DOI: 10.1016/j.jpedsurg.2020.05.003.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsThyroid cancerPediatric DTCAPSA Cancer CommitteeSurgical therapeutic approachUnresectable progressive diseaseLymph node basinCornerstone of treatmentAutoimmune thyroid diseaseLong-term recurrenceFine-needle aspirationNode basinTotal thyroidectomyProgressive diseaseSurgical resectionRadiological featuresSurvival outcomesCancer CommitteeThyroid diseaseTreatment strategiesFamily historyTreatment decisionsNeedle aspirationTherapeutic approachesThyroid carcinomaIodine deficiencyPostoperative Preablation TSH-Stimulated Thyroglobulin May Predict Outcome of Differentiated Thyroid Cancer in Children
Dinauer C. Postoperative Preablation TSH-Stimulated Thyroglobulin May Predict Outcome of Differentiated Thyroid Cancer in Children. Clinical Thyroidology 2020, 32: 131-134. DOI: 10.1089/ct.2020;32.131-134.Commentaries, Editorials and LettersRecurrence and Complications in Pediatric and Adolescent Papillary Thyroid Cancer in a High-Volume Practice
Rubinstein JC, Herrick-Reynolds K, Dinauer C, Morotti R, Solomon D, Callender GG, Christison-Lagay ER. Recurrence and Complications in Pediatric and Adolescent Papillary Thyroid Cancer in a High-Volume Practice. Journal Of Surgical Research 2020, 249: 58-66. PMID: 31923715, DOI: 10.1016/j.jss.2019.12.002.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge FactorsChildFemaleFollow-Up StudiesHospitals, High-VolumeHumansLymph NodesLymphatic MetastasisMaleNeoplasm Recurrence, LocalPostoperative ComplicationsPrognosisRetrospective StudiesRisk AssessmentRisk FactorsSurvival AnalysisThyroid Cancer, PapillaryThyroid GlandThyroid NeoplasmsThyroidectomyTreatment OutcomeYoung AdultConceptsPediatric papillary thyroid cancerLateral neck diseaseNeck diseasePapillary thyroid cancerNode involvementThyroid cancerExact testLymph node involvementCentral neck dissectionExtent of diseasePredictors of recurrenceRetrospective case seriesNon-Caucasian raceCox proportional hazardsLateral node involvementHigh-volume practiceFisher's exact testDisease recurrenceLymphovascular invasionMedian ageNeck dissectionCase seriesIndependent predictorsRetrospective reviewTumor size
2018
Lymph node ratio predicts recurrence in pediatric papillary thyroid cancer
Rubinstein JC, Dinauer C, Herrick-Reynolds K, Morotti R, Callender GG, Christison-Lagay ER. Lymph node ratio predicts recurrence in pediatric papillary thyroid cancer. Journal Of Pediatric Surgery 2018, 54: 129-132. PMID: 30361076, DOI: 10.1016/j.jpedsurg.2018.10.010.Peer-Reviewed Original ResearchConceptsPapillary thyroid cancerPediatric patientsTotal thyroidectomyNeck dissectionThyroid cancerN1b papillary thyroid cancerPediatric papillary thyroid cancerProphylactic central neck dissectionRegional lymph node metastasisCentral neck dissectionRetrospective case seriesLymph node metastasisRadical neck dissectionTime of presentationLikelihood of recurrenceTime of operationMedian ageMedian durationMetastatic LNsNode metastasisCase seriesPediatric populationPrognostic predictorSingle institutionSingle recurrence
2017
Balancing the benefits and harms of thyroid cancer surveillance in survivors of Childhood, adolescent and young adult cancer: Recommendations from the international Late Effects of Childhood Cancer Guideline Harmonization Group in collaboration with the PanCareSurFup Consortium
Clement SC, Kremer LCM, Verburg FA, Simmons JH, Goldfarb M, Peeters RP, Alexander EK, Bardi E, Brignardello E, Constine LS, Dinauer CA, Drozd VM, Felicetti F, Frey E, Heinzel A, van den Heuvel-Eibrink MM, Huang SA, Links TP, Lorenz K, Mulder RL, Neggers SJ, van Dijkum E, Oeffinger KC, van Rijn RR, Rivkees SA, Ronckers CM, Schneider AB, Skinner R, Wasserman JD, Wynn T, Hudson MM, Nathan PC, van Santen HM. Balancing the benefits and harms of thyroid cancer surveillance in survivors of Childhood, adolescent and young adult cancer: Recommendations from the international Late Effects of Childhood Cancer Guideline Harmonization Group in collaboration with the PanCareSurFup Consortium. Cancer Treatment Reviews 2017, 63: 28-39. PMID: 29202445, DOI: 10.1016/j.ctrv.2017.11.005.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsDifferentiated thyroid cancerChildhood Cancer Guideline Harmonization GroupInternational Late EffectsThyroid cancer surveillanceYoung adult cancerPanCareSurFup ConsortiumCancer surveillanceLate effectsAdult cancersInternational multidisciplinary panelSurvivors of childhoodTreatment of childhoodRelevant medical specialtiesHealth care providersNeck palpationSurveillance recommendationsSurveillance modalitiesThyroid cancerMultidisciplinary panelScreening practicesConsensus recommendationsThyroid ultrasoundCare providersAppropriate managementThyroid glandThe Pediatric Thyroid Nodule and Papillary Thyroid Cancer Management
Rivkees S, Dinauer C. The Pediatric Thyroid Nodule and Papillary Thyroid Cancer Management. 2017, 199-216. DOI: 10.1007/978-3-319-43618-0_13.ChaptersDifferentiated thyroid cancerPediatric thyroid cancerThyroid cancerPediatric differentiated thyroid cancerPediatric thyroid nodulesRisk of recurrenceThyroid cancer managementHigh recurrence rateBest care optionsDTC managementInitial therapyExcellent prognosisProspective trialRandomized trialsRecurrence ratePotential complicationsTreatment recommendationsCancer managementHigh incidenceRare diseaseTreatment approachesAdvanced stageUncommon occurrenceCare optionsThyroid nodules
2016
NTRK fusion oncogenes in pediatric papillary thyroid carcinoma in northeast United States
Prasad ML, Vyas M, Horne MJ, Virk RK, Morotti R, Liu Z, Tallini G, Nikiforova MN, Christison-Lagay ER, Udelsman R, Dinauer CA, Nikiforov YE. NTRK fusion oncogenes in pediatric papillary thyroid carcinoma in northeast United States. Cancer 2016, 122: 1097-1107. PMID: 26784937, DOI: 10.1002/cncr.29887.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentCarcinomaCarcinoma, PapillaryChildDNA Mutational AnalysisFemaleHigh-Throughput Nucleotide SequencingHumansMaleMutationNew EnglandNuclear Pore Complex ProteinsOncogene Proteins, FusionProto-Oncogene MasProto-Oncogene ProteinsProto-Oncogene Proteins B-rafProto-Oncogene Proteins c-etsProto-Oncogene Proteins c-retReceptor, trkAReceptor, trkCRepressor ProteinsReverse Transcriptase Polymerase Chain ReactionThyroid Cancer, PapillaryThyroid Neoplasms
2015
Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer
Francis GL, Waguespack SG, Bauer AJ, Angelos P, Benvenga S, Cerutti JM, Dinauer CA, Hamilton J, Hay ID, Luster M, Parisi MT, Rachmiel M, Thompson GB, Yamashita S. Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid 2015, 25: 716-759. PMID: 25900731, PMCID: PMC4854274, DOI: 10.1089/thy.2014.0460.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsDifferentiated thyroid cancerAmerican Thyroid AssociationThyroid cancerThyroid nodulesUnited States Preventive Services Task ForceFine needle aspiration cytologyRadioactive iodine therapyLong-term outcomesManagement of childrenFollicular thyroid cancerTask ForceScientific evidenceYears of ageLong-term harmIodine therapyPostoperative stagingAggressive treatmentThyrotropin suppressionClinical presentationPreoperative stagingSurgical managementOptimal careThyroid AssociationAspiration cytologyHigh risk
2013
Differentiated thyroid cancer in children
Bauer A, Francis G, Waguespack S, Dinauer C. Differentiated thyroid cancer in children. 2013, 106-118. DOI: 10.2217/ebo.12.534.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsDifferentiated thyroid cancerThyroid cancerHigh-volume thyroid surgeonPostoperative radioiodine therapyLymph node dissectionLife-long surveillanceLong-term sequelaePapillary thyroid cancerPediatric hospital settingLong-term riskRAI therapyResectable diseaseNode dissectionRecurrent diseaseSurgical resectionPediatric patientsRadioiodine therapyCancer 5Distant metastasisPreoperative stagingRepeat dosingThyroid surgeonsDisease progressionHospital settingPediatric cancer
2011
The Treatment of Differentiated Thyroid Cancer in Children: Emphasis on Surgical Approach and Radioactive Iodine Therapy
Rivkees SA, Mazzaferri EL, Verburg FA, Reiners C, Luster M, Breuer CK, Dinauer CA, Udelsman R. The Treatment of Differentiated Thyroid Cancer in Children: Emphasis on Surgical Approach and Radioactive Iodine Therapy. Endocrine Reviews 2011, 32: 798-826. PMID: 21880704, PMCID: PMC3591676, DOI: 10.1210/er.2011-0011.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsDifferentiated thyroid cancerPediatric thyroid cancerRadioactive iodine therapyThyroid cancerIodine therapyCentral compartment lymph node dissectionHigh-volume thyroid surgeonPediatric differentiated thyroid cancerLymph node dissectionRisk of recurrenceHigh recurrence rateFollicular thyroid cancerBest care optionsDTC managementNode dissectionTotal thyroidectomyExcellent prognosisProspective trialRemnant ablationInitial diagnosisRandomized trialsRecurrence rateResidual diseaseSurgical approachThyroid surgeons
2009
Chapter 98 The Use of 131Iodine in the Treatment of Graves’ Disease in Children
Rivkees S, Dinauer C. Chapter 98 The Use of 131Iodine in the Treatment of Graves’ Disease in Children. 2009, 942-955. DOI: 10.1016/b978-0-12-374135-6.00098-4.ChaptersGraves' diseaseRadioactive iodineThyroid cancerSide effectsLong-term adverse side effectsLong-term remission ratesRecurrent laryngeal nerve paresisPreferred definitive treatmentTreatment of GravesAcute side effectsBone marrow suppressionLaryngeal nerve paresisLong-term complicationsSerious adverse reactionsCurrent treatment optionsHigh cure ratesLarge thyroid glandForm of surgeryAdverse side effectsGenetic damageAntithyroid medicationDefinitive therapyNerve paresisPermanent hypoparathyroidismRemission rate
2008
Differentiated thyroid cancer in children: diagnosis and management
Dinauer CA, Breuer C, Rivkees SA. Differentiated thyroid cancer in children: diagnosis and management. Current Opinion In Oncology 2008, 20: 59-65. PMID: 18043257, DOI: 10.1097/cco.0b013e3282f30220.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsDifferentiated thyroid cancerThyroid cancerOptimal treatmentDifferentiated thyroid cancer treatmentPediatric thyroid cancerLymph node dissectionTime of diagnosisLarge case seriesCommon endocrine malignancyThyroid cancer treatmentAdvanced diseaseTotal thyroidectomyAdult patientsRemnant ablationYounger patientsPediatric patientsCase seriesSurgical approachFavorable outcomeEndocrine malignancyUnusual diseaseClinical approachRadioactive iodineCancerPatients
2007
Thyroid Cancer in Children
Dinauer C, Francis GL. Thyroid Cancer in Children. Endocrinology And Metabolism Clinics Of North America 2007, 36: 779-806. PMID: 17673128, DOI: 10.1016/j.ecl.2007.04.002.ChaptersConceptsDetectable serum thyroglobulinThyroid cancerSerum thyroglobulinNegative whole-body scanNegative imaging studiesManagement of childrenChildhood thyroid cancerRobust immune responseWhole-body scanYears of ageHigh-risk categoryGrowth factor expression patternsRecurrent diseaseUncommon tumorCurrent guidelinesImmune responseHigh riskImaging studiesCancerUnique subsetGenetic mutationsLimited dataChildrenPatientsThyroglobulinAn Optimal Treatment for Pediatric Graves’ Disease Is Radioiodine
Rivkees SA, Dinauer C. An Optimal Treatment for Pediatric Graves’ Disease Is Radioiodine. The Journal Of Clinical Endocrinology & Metabolism 2007, 92: 797-800. PMID: 17341574, DOI: 10.1210/jc.2006-1239.Commentaries, Editorials and LettersConceptsGraves' diseaseAntithyroid medicationRadioactive iodineThyroid cancerSide effectsLong-term adverse side effectsPediatric Graves' diseaseAcute side effectsLong-term remissionTreatment of hyperthyroidismAdverse side effectsMajority of childrenCurative therapyThyroid irradiationPediatric populationSpontaneous remissionOptimal treatmentSufficient dosesDefinite riskTreatment approachesMedicationsEffective cureDiseaseRemissionChildren
2002
Thyroid carcinomas that express telomerase follow a more aggressive clinical course in children and adolescents
Straight A, Patel A, Fenton C, Dinauer C, Tuttle R, Francis G. Thyroid carcinomas that express telomerase follow a more aggressive clinical course in children and adolescents. Journal Of Endocrinological Investigation 2002, 25: 302-308. PMID: 12030599, DOI: 10.1007/bf03344009.Peer-Reviewed Original ResearchConceptsFollicular thyroid carcinomaPapillary thyroid carcinomaThyroid carcinomaMalignant tumorsTelomerase expressionDisease-free survivalAggressive clinical courseChildhood thyroid cancerHigh recurrence riskYr of ageBenign thyroid lesionsLow telomerase expressionAutoimmune lesionsClinical courseDistant metastasisDirect invasionThyroid cancerBenign tumorsBlind examinerOriginal tumorBenign lesionsRecurrence riskTumorsThyroid lesionsCarcinoma
2001
Infiltration of Differentiated Thyroid Carcinoma by Proliferating Lymphocytes Is Associated with Improved Disease-Free Survival for Children and Young Adults1
Gupta S, Patel A, Folstad A, Fenton C, Dinauer C, Tuttle R, Conran R, Francis G. Infiltration of Differentiated Thyroid Carcinoma by Proliferating Lymphocytes Is Associated with Improved Disease-Free Survival for Children and Young Adults1. The Journal Of Clinical Endocrinology & Metabolism 2001, 86: 1346-1354. PMID: 11238531, DOI: 10.1210/jcem.86.3.7310.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinoma, FollicularAdolescentAdultCarcinoma, MedullaryCarcinoma, PapillaryCell DivisionChildDisease-Free SurvivalFemaleHumansImmunohistochemistryKi-67 AntigenLeukocyte Common AntigensLymphatic MetastasisLymphocytesMaleNeoplasm MetastasisNeoplasm Recurrence, LocalThyroid NeoplasmsConceptsDisease-free survivalPapillary thyroid carcinomaImproved disease-free survivalTumor-associated lymphocytesNumber of lymphocytesThyroid cancerThyroid carcinomaFollicular thyroid carcinomaHigh-power fieldYoung adultsAutoimmune thyroiditisImmune responseKi-67 positive lymphocytesRegional lymph node involvementMultifocal papillary thyroid carcinomaChildhood papillary thyroid carcinomasLymph node involvementDifferentiated thyroid cancerDifferentiated thyroid carcinomaLong-term outcomesPower fieldPresence of lymphocytesMedullary thyroid carcinomaHigh proliferation indexMajority of PTC
2000
Over‐expression of hepatocyte growth factor/scatter factor (HGF/SF) and the HGF/SF receptor (cMET) are associated with a high risk of metastasis and recurrence for children and young adults with papillary thyroid carcinoma
Ramirez R, Hsu D, Patel A, Fenton C, Dinauer C, Tuttle R, Francis G. Over‐expression of hepatocyte growth factor/scatter factor (HGF/SF) and the HGF/SF receptor (cMET) are associated with a high risk of metastasis and recurrence for children and young adults with papillary thyroid carcinoma. Clinical Endocrinology 2000, 53: 635-644. PMID: 11106926, DOI: 10.1046/j.1365-2265.2000.01124.x.Peer-Reviewed Original ResearchConceptsPapillary thyroid carcinomaFollicular thyroid carcinomaDisease-free survivalHGF/SF expressionMedullary thyroid carcinomaThyroid carcinomaHepatocyte growth factor/scatter factorGrowth factor/scatter factorYoung adultsFree survivalHigh riskHGF/SF receptorHGF/SFShorter disease-free survivalNormal thyroidExtent of diseaseSF expressionBenign thyroid disordersExpression of cMetIntensity of expressionMalignant thyroid lesionsClinical outcomesRetrospective groupThyroid disordersThyroid cancer