2002
Thyroid carcinomas that express telomerase follow a more aggressive clinical course in children and adolescents
Straight A, Patel A, Fenton C, Dinauer C, Tuttle R, Francis G. Thyroid carcinomas that express telomerase follow a more aggressive clinical course in children and adolescents. Journal Of Endocrinological Investigation 2002, 25: 302-308. PMID: 12030599, DOI: 10.1007/bf03344009.Peer-Reviewed Original ResearchConceptsFollicular thyroid carcinomaPapillary thyroid carcinomaThyroid carcinomaMalignant tumorsTelomerase expressionDisease-free survivalAggressive clinical courseChildhood thyroid cancerHigh recurrence riskYr of ageBenign thyroid lesionsLow telomerase expressionAutoimmune lesionsClinical courseDistant metastasisDirect invasionThyroid cancerBenign tumorsBlind examinerOriginal tumorBenign lesionsRecurrence riskTumorsThyroid lesionsCarcinoma
2000
Tyrosine kinase expression is increased in papillary thyroid carcinoma of children and young adults.
Patel A, Fenton C, Ramirez R, Dinauer CA, Tuttle RM, Nikiforov YE, Gary FL. Tyrosine kinase expression is increased in papillary thyroid carcinoma of children and young adults. Frontiers In Bioscience-Landmark 2000, 5: a1-9. PMID: 10702379, DOI: 10.2741/patel.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultCarcinoma, PapillaryChildEndothelial Growth FactorsFemaleGene Expression Regulation, NeoplasticHumansImmunohistochemistryLymphokinesMalePhosphorylationProtein-Tyrosine KinasesProto-Oncogene ProteinsProto-Oncogene Proteins c-metReceptor Protein-Tyrosine KinasesReceptors, Growth FactorReceptors, Vascular Endothelial Growth FactorRegistriesThyroid NeoplasmsTyrosineVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-1Vascular Endothelial Growth FactorsConceptsThyroid carcinomaRecurrence riskYoung adultsTK expressionTyrosine kinaseThyroid tissue blocksPapillary thyroid carcinomaTyrosine kinase expressionHepatocyte growth factor/scatter factorGrowth factor/scatter factorYounger patientsClinical behaviorBenign lesionsThyroid glandMalignant transformationIndividual tumorsTissue blocksKinase expressionCarcinomaDifferent tyrosine kinasesAdultsScatter factorChildrenPTCRisk