2015
Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer
Francis GL, Waguespack SG, Bauer AJ, Angelos P, Benvenga S, Cerutti JM, Dinauer CA, Hamilton J, Hay ID, Luster M, Parisi MT, Rachmiel M, Thompson GB, Yamashita S. Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid 2015, 25: 716-759. PMID: 25900731, PMCID: PMC4854274, DOI: 10.1089/thy.2014.0460.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsDifferentiated thyroid cancerAmerican Thyroid AssociationThyroid cancerThyroid nodulesUnited States Preventive Services Task ForceFine needle aspiration cytologyRadioactive iodine therapyLong-term outcomesManagement of childrenFollicular thyroid cancerTask ForceScientific evidenceYears of ageLong-term harmIodine therapyPostoperative stagingAggressive treatmentThyrotropin suppressionClinical presentationPreoperative stagingSurgical managementOptimal careThyroid AssociationAspiration cytologyHigh risk
2007
Thyroid Cancer in Children
Dinauer C, Francis GL. Thyroid Cancer in Children. Endocrinology And Metabolism Clinics Of North America 2007, 36: 779-806. PMID: 17673128, DOI: 10.1016/j.ecl.2007.04.002.ChaptersConceptsDetectable serum thyroglobulinThyroid cancerSerum thyroglobulinNegative whole-body scanNegative imaging studiesManagement of childrenChildhood thyroid cancerRobust immune responseWhole-body scanYears of ageHigh-risk categoryGrowth factor expression patternsRecurrent diseaseUncommon tumorCurrent guidelinesImmune responseHigh riskImaging studiesCancerUnique subsetGenetic mutationsLimited dataChildrenPatientsThyroglobulin
2000
Over‐expression of hepatocyte growth factor/scatter factor (HGF/SF) and the HGF/SF receptor (cMET) are associated with a high risk of metastasis and recurrence for children and young adults with papillary thyroid carcinoma
Ramirez R, Hsu D, Patel A, Fenton C, Dinauer C, Tuttle R, Francis G. Over‐expression of hepatocyte growth factor/scatter factor (HGF/SF) and the HGF/SF receptor (cMET) are associated with a high risk of metastasis and recurrence for children and young adults with papillary thyroid carcinoma. Clinical Endocrinology 2000, 53: 635-644. PMID: 11106926, DOI: 10.1046/j.1365-2265.2000.01124.x.Peer-Reviewed Original ResearchConceptsPapillary thyroid carcinomaFollicular thyroid carcinomaDisease-free survivalHGF/SF expressionMedullary thyroid carcinomaThyroid carcinomaHepatocyte growth factor/scatter factorGrowth factor/scatter factorYoung adultsFree survivalHigh riskHGF/SF receptorHGF/SFShorter disease-free survivalNormal thyroidExtent of diseaseSF expressionBenign thyroid disordersExpression of cMetIntensity of expressionMalignant thyroid lesionsClinical outcomesRetrospective groupThyroid disordersThyroid cancer
1999
Extensive surgery improves recurrence-free survival for children and young patients with class I papillary thyroid carcinoma
Dinauer C, Tuttle R, Robie D, McClellan D, Francis G. Extensive surgery improves recurrence-free survival for children and young patients with class I papillary thyroid carcinoma. Journal Of Pediatric Surgery 1999, 34: 1799-1804. PMID: 10626858, DOI: 10.1016/s0022-3468(99)90316-0.Peer-Reviewed Original ResearchConceptsPapillary thyroid cancerRisk of complicationsExtensive surgeryRadioactive iodineHigh riskThyroid hormonesRecurrent papillary thyroid cancerIncidence of complicationsRecurrence-free survivalRisk of recurrenceYears of agePapillary thyroid carcinomaInitial surgeryPermanent hypoparathyroidismSubtotal thyroidectomyTotal thyroidectomyAdjunctive therapySurgical complicationsSurgical groupYounger patientsMultifocal diseaseMultifocal tumorsContralateral lobeOptimal treatmentThyroid cancer
1998
Clinical features associated with metastasis and recurrence of differentiated thyroid cancer in children, adolescents and young adults
Dinauer C, Tuttle M, Robie D, McClellan D, Svec R, Adair C, Francis G. Clinical features associated with metastasis and recurrence of differentiated thyroid cancer in children, adolescents and young adults. Clinical Endocrinology 1998, 49: 619-628. PMID: 10197078, DOI: 10.1046/j.1365-2265.1998.00584.x.Peer-Reviewed Original ResearchConceptsDifferentiated thyroid cancerThyroid cancerClinical featuresMultifocal tumorsCases of FTCPalpable cervical lymphadenopathyRisk of recurrenceYears of ageCases of PTCCervical lymphadenopathyDistant recurrenceYounger patientsTumor RegistryFTC groupPathological findingsRetrospective studyLarge tumorsUnivariate analysisFollicular variantPTC groupHigh riskPatientsRecurrenceLower mortalityGreater risk