Over‐expression of hepatocyte growth factor/scatter factor (HGF/SF) and the HGF/SF receptor (cMET) are associated with a high risk of metastasis and recurrence for children and young adults with papillary thyroid carcinoma
Ramirez R, Hsu D, Patel A, Fenton C, Dinauer C, Tuttle R, Francis G. Over‐expression of hepatocyte growth factor/scatter factor (HGF/SF) and the HGF/SF receptor (cMET) are associated with a high risk of metastasis and recurrence for children and young adults with papillary thyroid carcinoma. Clinical Endocrinology 2000, 53: 635-644. PMID: 11106926, DOI: 10.1046/j.1365-2265.2000.01124.x.Peer-Reviewed Original ResearchConceptsPapillary thyroid carcinomaFollicular thyroid carcinomaDisease-free survivalHGF/SF expressionMedullary thyroid carcinomaThyroid carcinomaHepatocyte growth factor/scatter factorGrowth factor/scatter factorYoung adultsFree survivalHigh riskHGF/SF receptorHGF/SFShorter disease-free survivalNormal thyroidExtent of diseaseSF expressionBenign thyroid disordersExpression of cMetIntensity of expressionMalignant thyroid lesionsClinical outcomesRetrospective groupThyroid disordersThyroid cancerTyrosine kinase expression is increased in papillary thyroid carcinoma of children and young adults.
Patel A, Fenton C, Ramirez R, Dinauer CA, Tuttle RM, Nikiforov YE, Gary FL. Tyrosine kinase expression is increased in papillary thyroid carcinoma of children and young adults. Frontiers In Bioscience-Landmark 2000, 5: a1-9. PMID: 10702379, DOI: 10.2741/patel.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultCarcinoma, PapillaryChildEndothelial Growth FactorsFemaleGene Expression Regulation, NeoplasticHumansImmunohistochemistryLymphokinesMalePhosphorylationProtein-Tyrosine KinasesProto-Oncogene ProteinsProto-Oncogene Proteins c-metReceptor Protein-Tyrosine KinasesReceptors, Growth FactorReceptors, Vascular Endothelial Growth FactorRegistriesThyroid NeoplasmsTyrosineVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-1Vascular Endothelial Growth FactorsConceptsThyroid carcinomaRecurrence riskYoung adultsTK expressionTyrosine kinaseThyroid tissue blocksPapillary thyroid carcinomaTyrosine kinase expressionHepatocyte growth factor/scatter factorGrowth factor/scatter factorYounger patientsClinical behaviorBenign lesionsThyroid glandMalignant transformationIndividual tumorsTissue blocksKinase expressionCarcinomaDifferent tyrosine kinasesAdultsScatter factorChildrenPTCRisk