2020
A Functional Non-coding RNA Is Produced from xbp-1 mRNA
Liu X, Beaudoin JD, Davison CA, Kosmaczewski SG, Meyer BI, Giraldez AJ, Hammarlund M. A Functional Non-coding RNA Is Produced from xbp-1 mRNA. Neuron 2020, 107: 854-863.e6. PMID: 32640191, PMCID: PMC7486263, DOI: 10.1016/j.neuron.2020.06.015.Peer-Reviewed Original Research
2017
From the Cover: Manganese and Rotenone-Induced Oxidative Stress Signatures Differ in iPSC-Derived Human Dopamine Neurons
Neely M, Davison C, Aschner M, Bowman A. From the Cover: Manganese and Rotenone-Induced Oxidative Stress Signatures Differ in iPSC-Derived Human Dopamine Neurons. Toxicological Sciences 2017, 159: 366-379. PMID: 28962525, PMCID: PMC5837701, DOI: 10.1093/toxsci/kfx145.Peer-Reviewed Original ResearchConceptsReactive oxygen/nitrogen speciesOxygen/nitrogen speciesOxidative stress signatureDichlorodihydrofluorescein diacetate (DCFHDA) assayNitrogen speciesCellular oxidative stressOverall neuronal healthParkinson's diseaseOxidative stress endpointsCellular reduced glutathioneImpaired mitochondrial activityOxidative stressHuman dopamine neuronsDopamine neuronsOutcome measuresEnvironmental stressorsMitochondrial activityStress signatureStress endpointsNeuronal healthMesencephalic dopamine neuronsPD pathogenesisNeurite lengthMechanism of actionSpecies