2024
Development and evaluation of a questionnaire to capture environmental and occupational inhalational exposures in adults with fibrotic interstitial lung disease
Swaminathan A, McFatrich M, Mkumba L, Wright L, Redlich C, Snyder L, Reeve B, Patel D, Gulati M. Development and evaluation of a questionnaire to capture environmental and occupational inhalational exposures in adults with fibrotic interstitial lung disease. Respiratory Research 2024, 25: 372. PMID: 39407223, PMCID: PMC11481565, DOI: 10.1186/s12931-024-03000-z.Peer-Reviewed Original ResearchConceptsCognitive interviewsContent validityExposure questionnaireMultidisciplinary teamSemi-structured interview guideEvidence of content validityFibrosing ILDsInterstitial lung diseaseRelevant exposuresFibrotic interstitial lung diseaseClinically relevant exposuresTrained interviewersInterview guideAssessment QuestionnaireQuestionnaireInterviewsLung diseaseAdultsTeamClinicPatientsSource of misunderstandingOccupational inhalation exposureValidityDisease
2023
Thrombocytopenia Associated with Elemental Mercury Poisoning in Two Siblings — Connecticut, July 2022
Hogeland E, Somers T, Yip L, Doyon S, Redlich C, Orsey A, Woda C, Swan S, Feder H. Thrombocytopenia Associated with Elemental Mercury Poisoning in Two Siblings — Connecticut, July 2022. MMWR Morbidity And Mortality Weekly Report 2023, 72: 1027-1031. PMID: 37733629, PMCID: PMC10519713, DOI: 10.15585/mmwr.mm7238a2.Peer-Reviewed Original ResearchConceptsIntravenous immune globulinSevere thrombocytopeniaElemental mercury poisoningImmune thrombocytopenic purpuraThrombopoietin receptor agonistsPossible infectious causesElemental mercury toxicityPublic health outreachPetechial rashOral mucositisImmune globulinProlonged hospitalizationInfectious causesPlatelet transfusionsThrombocytopenic purpuraThrombocytopenia AssociatedReceptor agonistHealth outreachPoison controlEarly detectionToxic exposureMercury exposureEnvironmental exposuresMercury poisoningDimercaptosuccinic acidEngineered Stone–Associated Silicosis—A Lethal Variant of an Ancient Disease
Hua J, Rose C, Redlich C. Engineered Stone–Associated Silicosis—A Lethal Variant of an Ancient Disease. JAMA Internal Medicine 2023, 183: 908-910. PMID: 37486690, DOI: 10.1001/jamainternmed.2023.3260.Peer-Reviewed Original ResearchCOVID-19 Infections and Predictors of Sickness Related Absences Among Healthcare Workers
Sakr C, Fakih L, Melhem N, Fakhreddine M, Musharrafieh U, Banna H, Doudakian R, Zahreddine N, Tannous J, Kanj S, Slade M, Redlich C, Rahme D. COVID-19 Infections and Predictors of Sickness Related Absences Among Healthcare Workers. Journal Of Occupational And Environmental Medicine 2023, 65: 590-594. PMID: 37015731, PMCID: PMC10332510, DOI: 10.1097/jom.0000000000002857.Peer-Reviewed Original ResearchConceptsCOVID-19 infectionHealthcare workersSick leave daysLeave daysSick leaveCross-sectional study designMonths of infectionLonger sick leaveCOVID-19Public health interventionsRegression analysisLinear regression analysisHealth interventionsStudy designInfectionSick leavesRelated absencesFuture pandemicsCOVID-19 pandemicPredictorsPandemicDaysLeaveNursesMonthsOccupational Risk Factors for SARS-CoV-2 Seropositivity in Healthcare Workers
Fazen L, Abad Q, Smith R, Santiago R, Liu J, Wisnewski A, Redlich C. Occupational Risk Factors for SARS-CoV-2 Seropositivity in Healthcare Workers. Journal Of Occupational And Environmental Medicine 2023, 65: 521-528. PMID: 36893070, PMCID: PMC10227858, DOI: 10.1097/jom.0000000000002831.Peer-Reviewed Original ResearchConceptsHealthcare workersRisk factorsSARS-CoV-2 immunoglobulin GSARS-CoV-2 seropositivityMultivariable-adjusted logistic regressionCox proportional hazards modelVaccine-induced immunityCOVID-19 risk factorsOccupational risk factorsLongitudinal cohort studyProportional hazards modelOccupational health interventionsRole of physiciansCOVID-19 riskCohort studyHazards modelHealth interventionsInternal medicineLogistic regressionResident physiciansImmunoglobulin GPhysiciansCOVID-19 pandemicSeropositivityVaccination
2022
The Future of Occupational and Environmental Medicine
Green-McKenzie J, Khan A, Redlich CA, Margarin A, McKinney ZJ. The Future of Occupational and Environmental Medicine. Journal Of Occupational And Environmental Medicine 2022, 64: e857-e863. PMID: 35960857, DOI: 10.1097/jom.0000000000002676.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsOEM physiciansPopulation healthEnvironmental medicinePreventive medicine specialtyClinical practiceResultant injurySocial determinantsMedicine specialtyResidency trainingPhysiciansHealthClinical medicineMedicineTraining programEmergency preparednessRisk assessmentInjuryIllnessEpidemiologySettingDiverse settingsOccupational Exposures in Nontuberculous Mycobacterial Pulmonary Disease
Blanc PD, Balmes JR, Redlich C. Occupational Exposures in Nontuberculous Mycobacterial Pulmonary Disease. CHEST Journal 2022, 162: e106-e107. PMID: 35940661, DOI: 10.1016/j.chest.2022.03.049.Commentaries, Editorials and LettersChanges Over Time in COVID-19 Incidence, Vaccinations, Serum Spike IgG, and Viral Neutralizing Potential Among Individuals From a North American Gaming Venue
Wisnewski AV, Cantley L, Luna J, Liu J, Smith RF, Hager K, Redlich CA. Changes Over Time in COVID-19 Incidence, Vaccinations, Serum Spike IgG, and Viral Neutralizing Potential Among Individuals From a North American Gaming Venue. Journal Of Occupational And Environmental Medicine 2022, 64: 788-796. PMID: 36054278, PMCID: PMC9426317, DOI: 10.1097/jom.0000000000002617.Peer-Reviewed Original ResearchConceptsOccupational risk factorsCOVID-19 historyRisk factorsAnti-spike IgG levelsIndividual humoral responsesSerum antiviral antibodiesCOVID-19 vaccinationEnzyme-linked immunosorbent assayCOVID-19 ratesCOVID-19 incidenceSpike IgGVaccine nonrespondersVaccination statusIgG levelsVaccine responsesVaccine typesAntiviral antibodiesHumoral responseCOVID-19 casesVaccine availabilityImmunosorbent assayVaccinationInfectionMonthsParticipantsAssessment of personal inhalation and skin exposures to polymeric methylene diphenyl diisocyanate during polyurethane fabric coating
Harari H, Bello D, Woskie S, Redlich CA. Assessment of personal inhalation and skin exposures to polymeric methylene diphenyl diisocyanate during polyurethane fabric coating. Toxicology And Industrial Health 2022, 38: 622-635. PMID: 35694796, DOI: 10.1177/07482337221107243.Peer-Reviewed Original ResearchConceptsSkin exposurePersonal inhalationOccupational asthmaHypersensitivity pneumonitisContact dermatitisInitial sensitizationWork exposureArea air samplesInhalation exposureOccupational limitsLiquid chromatography-tandem mass spectrometryHealth effects studiesHealth effectsPersonal airborne samplesGeometric meanChromatography-tandem mass spectrometryExposure characterizationInhalationExposureFuture studiesGreater exposureAirborne levelsSubstantial variabilityProtective measuresGeometric standard deviationReducing asthma exacerbations in vulnerable children through a medical–legal partnership
Mainardi AS, Harris D, Rosenthal A, Redlich CA, Hu B, Fenick AM. Reducing asthma exacerbations in vulnerable children through a medical–legal partnership. Journal Of Asthma 2022, 60: 262-269. PMID: 35188437, DOI: 10.1080/02770903.2022.2045307.Peer-Reviewed Original ResearchConceptsMedical-legal partnershipsAsthma exacerbationsEmergency departmentHealth disparitiesAsthma exacerbation ratePrimary care officesAcademic children's hospitalAsthma health disparitiesExacerbation rateHealthcare utilizationPediatric populationChildren's HospitalCare officesPrimary careWorse outcomesChronic illnessInpatient settingStudy populationAsthmaTotal encountersSocial determinantsHospitalizationExacerbationStatistical significanceInterventionDeterminants of indoor carbonaceous aerosols in homes in the Northeast United States
Deslauriers JR, Redlich CA, Kang CM, Grady ST, Slade M, Koutrakis P, Garshick E. Determinants of indoor carbonaceous aerosols in homes in the Northeast United States. Journal Of Exposure Science & Environmental Epidemiology 2022, 33: 1-7. PMID: 35079108, PMCID: PMC9309189, DOI: 10.1038/s41370-021-00405-6.Peer-Reviewed Original ResearchDevelopment and utilization of a surrogate SARS-CoV-2 viral neutralization assay to assess mRNA vaccine responses
Wisnewski AV, Liu J, Lucas C, Klein J, Iwasaki A, Cantley L, Fazen L, Luna J, Slade M, Redlich CA. Development and utilization of a surrogate SARS-CoV-2 viral neutralization assay to assess mRNA vaccine responses. PLOS ONE 2022, 17: e0262657. PMID: 35041700, PMCID: PMC8765639, DOI: 10.1371/journal.pone.0262657.Peer-Reviewed Original ResearchConceptsPlaque reduction neutralization testCOVID-19 patientsVaccine responsesRecovered COVID-19 patientsSARS-CoV-2 immunityBooster vaccine dosesMRNA vaccine responsePost-vaccine seraCompetitive ELISAEnzyme 2 (ACE2) receptorReduction neutralization testType of vaccineSARS-CoV-2 spike protein receptorSpike protein receptorVaccine seraVaccine recipientsPost vaccinationVaccinated individualsVaccine dosesViral culturePrior historyViral neutralizationNeutralization testBooster shotsPost vaccineSevere asthma and death in a worker using methylene diphenyl diisocyanate MDI asthma death
Wisnewski AV, Cooney R, Hodgson M, Giese K, Liu J, Redlich CA. Severe asthma and death in a worker using methylene diphenyl diisocyanate MDI asthma death. American Journal Of Industrial Medicine 2022, 65: 166-172. PMID: 35028957, PMCID: PMC8846433, DOI: 10.1002/ajim.23323.Peer-Reviewed Case Reports and Technical NotesConceptsCause of deathMedical recordsDiisocyanate asthmaSevere asthmaSerum IgEParaffin-embedded lung tissue sectionsWorkers' medical recordsSmooth muscle hypertrophyTotal serum IgEHallmark of asthmaSevere asthma attacksBasement membrane thickeningLung tissue sectionsPost-mortem findingsEnzyme-linked immunosorbent assayPotential chemical exposuresInflamed airwaysMucus pluggingOccupational asthmaPulmonary embolismTotal IgEAsthma deathsAsthma attacksLung pathologyAutopsy findings
2021
Reply to letter to the editor concerning Gui et al. Inception cohort study of workers exposed to toluene diisocyanate at a polyurethane foam factory
Wisnewski AV, Redlich CA. Reply to letter to the editor concerning Gui et al. Inception cohort study of workers exposed to toluene diisocyanate at a polyurethane foam factory. American Journal Of Industrial Medicine 2021, 64: 1055-1056. PMID: 34647343, DOI: 10.1002/ajim.23299.Commentaries, Editorials and LettersTo Be (B Read) or Not to Be (B Read), That Is the Question: Conflict of Interest and Radiographic Interpretation
Redlich CA, Rosenman KD. To Be (B Read) or Not to Be (B Read), That Is the Question: Conflict of Interest and Radiographic Interpretation. Annals Of The American Thoracic Society 2021, 18: 1618-1619. PMID: 34596497, PMCID: PMC8522284, DOI: 10.1513/annalsats.202107-764ed.Commentaries, Editorials and LettersConflict of InterestHumansOccupational health disparities: The pandemic as prism and prod
Brigham E, Harris D, Carlsten C, Redlich CA. Occupational health disparities: The pandemic as prism and prod. Journal Of Allergy And Clinical Immunology 2021, 148: 1148-1150. PMID: 34534567, PMCID: PMC8452464, DOI: 10.1016/j.jaci.2021.09.007.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsImmunogenic amino acid motifs and linear epitopes of COVID-19 mRNA vaccines
Wisnewski AV, Redlich CA, Liu J, Kamath K, Abad QA, Smith RF, Fazen L, Santiago R, Luna J, Martinez B, Baum-Jones E, Waitz R, Haynes WA, Shon JC. Immunogenic amino acid motifs and linear epitopes of COVID-19 mRNA vaccines. PLOS ONE 2021, 16: e0252849. PMID: 34499652, PMCID: PMC8428655, DOI: 10.1371/journal.pone.0252849.Peer-Reviewed Original ResearchConceptsCOVID-19 mRNA vaccine recipientsLinear epitopesSARS-CoV-2 neutralizationCOVID-19 mRNA vaccinesVaccine-induced IgGMRNA vaccine recipientsSARS-CoV-2 spike proteinDominant linear epitopeElicit IgGVaccine recipientsVaccine effectivenessMRNA vaccinesVaccination samplesImmune escapeHuman coronavirusesHealthy adultsSARS-CoVVaccine epitopesCritical epitopesAdverse responsesReverse vaccinologySpike proteinNatural infectionS2 subunitIgGAssociations of SARS-CoV-2 serum IgG with occupation and demographics of military personnel
Zell J, Wisnewski AV, Liu J, Klein J, Lucas C, Slade M, Iwasaki A, Redlich CA. Associations of SARS-CoV-2 serum IgG with occupation and demographics of military personnel. PLOS ONE 2021, 16: e0251114. PMID: 34460832, PMCID: PMC8405017, DOI: 10.1371/journal.pone.0251114.Peer-Reviewed Original ResearchConceptsSARS-CoV-2Live SARS-CoV-2Moderate SARS-CoV-2SARS-CoV-2 seroprevalenceWork-related risk factorsTransportation-related occupationsSerum IgG levelsAntigen-specific IgGIgG seropositivity rateBiomarkers of infectionSARS-CoV-2 spikeCOVID-19 exposureUS National Guard soldiersMilitary personnelIgG levelsSeropositivity rateHumoral responseSerum IgGViral exposureBlack raceRisk factorsOdds ratioStudy populationNational Guard soldiersDemographic dataHuman IgG and IgA responses to COVID-19 mRNA vaccines
Wisnewski AV, Luna J, Redlich CA. Human IgG and IgA responses to COVID-19 mRNA vaccines. PLOS ONE 2021, 16: e0249499. PMID: 34133415, PMCID: PMC8208542, DOI: 10.1371/journal.pone.0249499.Peer-Reviewed Original ResearchConceptsCOVID-19 mRNA vaccinesAntigen-specific IgGMRNA vaccinesIgG levelsCOVID-19 mRNA vaccinationAntigen-specific IgG levelsInitial vaccine doseAntigen-specific IgASARS-CoV-2More rapid declineSecond vaccineVaccine doseMRNA vaccinationIgA responsesSerum levelsVaccine dosesSpecific IgGNatural immunityViral neutralizationIgAVaccinePeak levelsIgGVaccinationHuman IgGSARS-CoV-2 Infection Hospitalization Rate and Infection Fatality Rate Among the Non-Congregate Population in Connecticut
Mahajan S, Caraballo C, Li SX, Dong Y, Chen L, Huston SK, Srinivasan R, Redlich CA, Ko AI, Faust JS, Forman HP, Krumholz HM. SARS-CoV-2 Infection Hospitalization Rate and Infection Fatality Rate Among the Non-Congregate Population in Connecticut. The American Journal Of Medicine 2021, 134: 812-816.e2. PMID: 33617808, PMCID: PMC7895685, DOI: 10.1016/j.amjmed.2021.01.020.Peer-Reviewed Original ResearchConceptsInfection hospitalization rateInfection fatality rateHospitalization ratesFatality rateSeroprevalence estimatesSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodiesSARS-CoV-2 antibodiesConnecticut Hospital AssociationNon-Hispanic black peopleProportion of deathsCoronavirus disease 2019Total infected individualsTotal hospitalizationsAdverse outcomesNon-congregate settingsHigh burdenDisease 2019Prevalence studyMost subgroupsInfected individualsHospitalizationOlder peopleHospital AssociationConnecticut DepartmentDeath