1998
Acute Neuroleptic Treatment in Elderly Patients Without Dementia
Mazure C, Nelson J, Jatlow P, Bowers M. Acute Neuroleptic Treatment in Elderly Patients Without Dementia. American Journal Of Geriatric Psychiatry 1998, 6: 221-229. PMID: 9659955, DOI: 10.1097/00019442-199800630-00005.Peer-Reviewed Original ResearchConceptsNon-elderly adultsElderly patientsNeuroleptic treatmentAcute responseLow dosesLow-dose neuroleptic treatmentAcute neuroleptic treatmentAdverse effectsHigh-dose treatmentLow-dose treatmentDrug blood levelsPrimary psychotic illnessInitial doseBlood levelsPsychotic illnessEffective treatmentPatientsDose ratioLonger durationTreatmentLower ratesDosesAdultsResponseNeuroleptics
1997
The Expanding Indications for Clozapine
Young C, Longhurst J, Bowers M, Mazure C. The Expanding Indications for Clozapine. Experimental And Clinical Psychopharmacology 1997, 5: 216-234. PMID: 9260069, DOI: 10.1037/1064-1297.5.3.216.Peer-Reviewed Original ResearchConceptsUnique pharmacodynamic profileUse of clozapineTreatment-resistant schizophreniaTraditional drug treatmentExpanding IndicationsClozapine treatmentNeurologic conditionsPharmacodynamic profileClinical indicationsDrug treatmentMood disordersEffective treatmentClozapineSubstance abuseChildhood schizophreniaRelevant literatureSchizophreniaDisordersTreatmentAggressive behaviorIndicationsInitial rationaleAgranulocytosisPatientsBody of literature