2012
Mineralizing Enthesopathy Is a Common Feature of Renal Phosphate-Wasting Disorders Attributed to FGF23 and Is Exacerbated by Standard Therapy in Hyp Mice
Karaplis A, Bai X, Falet J, Macica C. Mineralizing Enthesopathy Is a Common Feature of Renal Phosphate-Wasting Disorders Attributed to FGF23 and Is Exacerbated by Standard Therapy in Hyp Mice. Endocrinology 2012, 153: 5906-5917. PMID: 23038738, PMCID: PMC3512070, DOI: 10.1210/en.2012-1551.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsExtracellular Matrix ProteinsFamilial Hypophosphatemic RicketsFemaleFibroblast Growth Factor-23Fibroblast Growth FactorsGenetic Diseases, X-LinkedImmunohistochemistryKidneyMaleMiceMice, Inbred C57BLMice, TransgenicModels, GeneticMutationPedigreePhosphatesPhosphoproteinsRheumatic DiseasesTransgenesUp-RegulationConceptsPhosphate-wasting disordersStandard therapyFGF23 levelsElevated fibroblast growth factor 23Hyp miceRenal phosphate-wasting disordersFibroblast growth factor 23High FGF23 levelsGrowth factor 23Elevated FGF23 levelsAction of FGF23Dentin matrix acidic phosphoprotein 1Phosphate wasting disorderAutosomal recessive hypophosphatemic ricketsRecessive hypophosphatemic ricketsLigament insertion sitesChildhood managementOral phosphateFactor 23Achilles insertionDisease morbidityPotential morbidityBone spursUntoward effectsMurine model
1991
Localization of endothelin-like immunoreactivity in rat kidneys
Wilkes B, Susin M, Mento P, Macica C, Girardi E, Boss E, Nord E. Localization of endothelin-like immunoreactivity in rat kidneys. American Journal Of Physiology 1991, 260: f913-f920. PMID: 2058711, DOI: 10.1152/ajprenal.1991.260.6.f913.Peer-Reviewed Original ResearchConceptsEndothelin-like immunoreactivityVasa rectaeEndothelin-1Renal papillaRat kidneyProximal tubule brush borderDistal nephron segmentsTubule brush borderNormal rat kidneyGlomerular immunostainingArcuate arteriesPeritubular capillariesRenal cortexRenal tissueImmunoperoxidase techniqueParacrine actionIntense immunostainingCytoplasmic immunostainingDuct epitheliumImmunostaining densityRenal medullaBig endothelinNephron segmentsImmunoreactivityImmunostainingGlomerular endothelin receptors during initiation and maintenance of ischemic acute renal failure in rats
Wilkes B, Pearl A, Mento P, Maita M, Macica C, Girardi E. Glomerular endothelin receptors during initiation and maintenance of ischemic acute renal failure in rats. American Journal Of Physiology 1991, 260: f110-f118. PMID: 1847009, DOI: 10.1152/ajprenal.1991.260.1.f110.Peer-Reviewed Original ResearchConceptsIschemic acute renal failureAcute renal failureRenal blood flowGlomerular filtration rateET receptorsRenal failureEndothelin receptorsET infusionElevated ET levelsLeft renal arteryMean arterial pressureNormal Sprague-Dawley ratsSprague-Dawley ratsReceptor sitesRenal hemodynamicsArterial pressureContralateral kidneyRenal arteryFiltration rateReceptor numberBlood flowET levelsRatsET bindingAdditional studies