2017
Established patterns of animal study design undermine translation of disease-modifying therapies for Parkinson’s disease
Zeiss CJ, Allore HG, Beck AP. Established patterns of animal study design undermine translation of disease-modifying therapies for Parkinson’s disease. PLOS ONE 2017, 12: e0171790. PMID: 28182759, PMCID: PMC5300282, DOI: 10.1371/journal.pone.0171790.Peer-Reviewed Original ResearchConceptsDisease-modifying therapiesClinical outcome measuresDisease-modifying interventionsNon-human primatesParkinson's diseaseOutcome measuresStudy designHuman studiesToxin-induced modelsHuman interventional studiesLongitudinal clinical outcomesPreclinical study designStudy design dataToxic protocolsClinical outcomesContemporary cohortNeuropathologic dataStudy design factorsInterventional studyMultiple time pointsPD phenotypeAnimal studiesIntervention characteristicsIntervention categoriesProgressive nature
2007
Motor deficits and altered striatal gene expression in aphakia (ak) mice
Singh B, Wilson JH, Vasavada HH, Guo Z, Allore HG, Zeiss CJ. Motor deficits and altered striatal gene expression in aphakia (ak) mice. Brain Research 2007, 1185: 283-292. PMID: 17949697, PMCID: PMC3904435, DOI: 10.1016/j.brainres.2007.09.006.Peer-Reviewed Original ResearchConceptsSubstantia nigra pars compactaMonths of lifeAK miceWT miceParkinson's diseaseMotor performanceStriatal gene expressionDopaminergic denervationNigrostriatal dysfunctionStriatal denervationMotor deficitsPars compactaMotor abnormalitiesAphakia miceMice progressMotor functionStriatal transcriptomeDRD2 expressionPole testWT controlsSemi-quantitative RT-PCRAge groupsMiceRT-PCRTime points