Carlos Grilo, PhD
Professor of Psychiatry and of PsychologyCards
About
Titles
Professor of Psychiatry and of Psychology
Director, Program for Obesity, Weight and Eating Research (POWER) at Yale, Psychiatry
Biography
Dr. Grilo is an internationally-recognized expert on eating disorders, obesity, and manifestations of disordered eating. His secondary clinical-research interests include psychopathology, personality disorders, addictions, and the sociocultural contexts of functioning. Dr. Grilo’s current work focuses on performing controlled treatment studies testing behavioral, cognitive-behavioral, guided-self-help scalable treatments, and pharmacological interventions for eating/weight disorders in diverse patient groups/settings, including bariatric surgery. Dr. Grilo’s current RCTs include adaptive “SMART” stepped-care designs for binge-eating disorder and obesity. His current collaborative work is interdisciplinary, integrating laboratory and neurobiological methods, extending across diverse settings and patient groups, and includes epidemiological and longitudinal outcome studies, with an increasing emphasis on health disparities and stigma.
Dr. Grilo has been continuously funded by the National Institutes of Health (NIH) for 30 years and has served as Principal Investigator on 20 NIH grants. Dr. Grilo received two K24 Mid-Career Investigator Awards in Eating/Weight Disorders from the NIH/NIDDK, which reflect his longstanding commitment to training and mentoring and in collaborative clinical-research activities. Dr. Grilo’s involvement with the psychology training program dates back to 1993-2000, when he coordinated the pre-doctoral internship and postdoctoral training programs at the Yale Psychiatric Institute while serving as Director of Psychology.
Dr. Grilo currently serves on the editorial boards of 10 professional journals, including the Journal of Consulting and Clinical Psychology and the American Psychologist. Dr. Grilo has published over 510 peer-reviewed journal articles (“h” index of 90 with over 29,500 citations on SCOPUS; "discipline-H" index of 119 with 45,800 citations on Research.com), 25 chapters, and two books on eating and weight disorders.
In his capacity as Director of POWER, Dr. Grilo provides leadership of this entirely grant-funded clinical-research and training program focused on eating/weight disorders. POWER provides research training to students/trainees (undergraduate, graduate, pre-doctoral, post-doctoral, and junior faculty levels) with interests in academic careers; the primary focus is on post-doctoral training.
Appointments
Psychiatry
ProfessorPrimaryDepartment of Psychology
ProfessorSecondary
Other Departments & Organizations
- Department of Psychology
- Obesity Research Working Group
- Program for Obesity, Weight and Eating Research (POWER) at Yale
- Psychiatry
- Psychology Section
- Stress & Addiction Clinical Research Program
- Yale Medicine
- Yale Stress Center
- Yale Ventures
Education & Training
- Postdoc
- Clinical Psychology Yale University (1992)
- Internship
- Clinical Psychology Harvard Medical School (1992)
- Fellowship
- Clinical Psychology Harvard Medical School (1992)
- PhD
- University of Pittsburgh (1991)
Research
Publications
2024
Lisdexamfetamine maintenance treatment for binge-eating disorder following successful treatments: randomized double-blind placebo-controlled trial.
Grilo C, Ivezaj V, Yurkow S, Tek C, Wiedemann A, Gueorguieva R. Lisdexamfetamine maintenance treatment for binge-eating disorder following successful treatments: randomized double-blind placebo-controlled trial. Psychological Medicine 2024, 1-11. PMID: 39258475, DOI: 10.1017/s003329172400148x.Peer-Reviewed Original ResearchEating-disorder psychopathologyBinge-eating disorderMaintenance treatmentAcute treatmentBinge-eating remission ratesCognitive-behavioral therapyEfficacy of lisdexamfetamineSignificant weight gainDouble-blind placebo-controlled trialAcute respondersLisdexamfetamine treatmentPsychopathological outcomesPosttreatment assessmentLisdexamfetaminePlacebo-controlled trialRandomized double-blind placebo-controlled trialSingle-site trialAssociated with significant weight lossPsychopathologyBinge-eatingRemission rateWeight lossPlaceboRelapse rateControl researchExploring Dietary Restraint as a Mediator of Behavioral and Cognitive‐Behavioral Treatments on Outcomes for Patients With Binge‐Eating Disorder With Obesity
Grilo C, Pittman B. Exploring Dietary Restraint as a Mediator of Behavioral and Cognitive‐Behavioral Treatments on Outcomes for Patients With Binge‐Eating Disorder With Obesity. International Journal Of Eating Disorders 2024 PMID: 39247962, DOI: 10.1002/eat.24288.Peer-Reviewed Original ResearchCognitive-behavioral therapyBehavioral weight lossBinge-eating disorderBinge eatingWeight loss outcomesCognitive-behavioral treatmentMediation of behaviorEDE-Q restraintPost-treatmentCognitive-behavioralRestraint ScaleDietary restraintBingeMediation effectEatingEffects of treatmentTreatment effectsDisordersRandomized controlled trialsWeight lossMonths of treatmentHypothesis-testingSecondary analysisRestraintBinge-eatingTrauma‐Focused Cognitive‐Behavioral Therapy for Adolescents Bullied Because of Weight: A Feasibility Study
Lydecker J, Ozbardakci E, Lou R, Grilo C. Trauma‐Focused Cognitive‐Behavioral Therapy for Adolescents Bullied Because of Weight: A Feasibility Study. International Journal Of Eating Disorders 2024 PMID: 39007703, DOI: 10.1002/eat.24257.Peer-Reviewed Original ResearchCognitive-behavioral therapyTraumatic stressClinically-meaningful improvementsTrauma-focused cognitive behavioral therapyTrauma-focused cognitive-behavioral therapyPatient outcomesOvervaluation of weight/shapeSymptoms of traumatic stressWeight-related bullyingCognitive behavioral therapyCognitive-behavioralTrauma-focusedWithin-subject improvementIntrusive symptomsBehavioral therapyDietary restraintEating disordersTherapyTreatment satisfactionFunctional impairmentTreatment feasibilityAdolescentsPatientsWeight/shapeFeasibility trialTreatment of Eating Disorders: Current Status, Challenges, and Future Directions
Grilo C. Treatment of Eating Disorders: Current Status, Challenges, and Future Directions. Annual Review Of Clinical Psychology 2024, 20: 97-123. PMID: 38211625, DOI: 10.1146/annurev-clinpsy-080822-043256.Peer-Reviewed Original ResearchAnorexia nervosaBinge-eating disorderBulimia nervosaEating disordersAdaptive treatment designsPsychological treatmentTreatment researchNervosaTreatment designDisordersBulimiaPharmacological optionsAnorexiaEnhanced outcomesExpected final online publication dateFirst-line approachOnline publication dateMedicationFirst-lineClinical guidanceAnnual ReviewAlternative treatmentRevised estimatesPatientsTreatmentNeural Responses to Auditory Food Stimuli Following Cognitive Behavioral Therapy for Binge‐Eating Disorder
Chao A, Agarwal K, Zhou Y, Grilo C, Gur R, Joseph P, Shinohara R, Richmond T, Wadden T. Neural Responses to Auditory Food Stimuli Following Cognitive Behavioral Therapy for Binge‐Eating Disorder. International Journal Of Eating Disorders 2024 PMID: 38953334, DOI: 10.1002/eat.24244.Peer-Reviewed Original ResearchCognitive behavioral therapyFunctional magnetic resonance imagingBlood oxygen level-dependentWait-list controlBinge-eating disorderBehavioral therapyFunctional magnetic resonance imaging sessionNeutral-relaxing cuesReward-based eating driveReward-related regionsReducing binge eatingMeasured BOLD responsesReward regionsBinge eatingBinge-eating episodesFood cuesEating drivePersonalized scriptsBOLD responseRandomized controlled trialsNeural responsesFood-stimuliBinge-eatingCuesMagnetic resonance imagingObesity in Latinx and White U.S. military veterans: Mental health, psychosocial burden, non-suicidal self-injury and suicidal behavior
Stefanovics E, Grilo C, Potenza M, Pietrzak R. Obesity in Latinx and White U.S. military veterans: Mental health, psychosocial burden, non-suicidal self-injury and suicidal behavior. Psychiatry Research 2024, 335: 115844. PMID: 38484606, DOI: 10.1016/j.psychres.2024.115844.Peer-Reviewed Original ResearchNon-suicidal self-injuryDrug use disordersU.S. military veteransMental health problemsMilitary veteransSelf-injuryUse disorderSymptoms of internalizing disordersLevels of childhood traumaNational Health and ResiliencePost-traumatic stress disorderIncreased risk of mental health problemsWhite veteransCoping self-efficacyRisk of mental health problemsLatinx ethnicityGeneralized anxietyStress disorderChildhood traumaHealth problemsSuicidal behaviorVeterans StudyCorrelates of obesityCulturally sensitive preventionNationally representative sampleOvervaluation of shape/weight at posttreatment predicts relapse at 12‐month follow‐up after successful behaviorally‐based treatment of binge‐eating disorder
Grilo C, Ivezaj V, Gueorguieva R. Overvaluation of shape/weight at posttreatment predicts relapse at 12‐month follow‐up after successful behaviorally‐based treatment of binge‐eating disorder. International Journal Of Eating Disorders 2024, 57: 1268-1273. PMID: 38321617, PMCID: PMC11093697, DOI: 10.1002/eat.24141.Peer-Reviewed Original ResearchOvervaluation of shape/weightEating-disorder psychopathologyBinge-eating disorderEating Disorder Examination interviewBeck Depression InventoryWeight loss treatmentClinical overvaluationBinge-eating frequencyDiagnostic specifierBinge eatingNon-abstinenceExamination interviewDepression InventoryShape/weightDepression scoresFollow-upPsychopathologyAbstinenceBingeDepressionClinical implicationsDepression 1PosttreatmentDisordersOvervaluationReliability of the original and brief versions of the Eating Disorder Examination in binge‐eating disorder
Lydecker J, Ivezaj V, Wiedemann A, Kerrigan S, Grilo C. Reliability of the original and brief versions of the Eating Disorder Examination in binge‐eating disorder. Obesity 2024, 32: 702-709. PMID: 38311600, PMCID: PMC10965370, DOI: 10.1002/oby.23993.Peer-Reviewed Original ResearchEating Disorder ExaminationEating Disorder Examination interviewEating-disorder psychopathologyBinge-eating disorderInternal consistencyDoctoral-levelIndicators of loss of controlInterrater reliabilityLoss of controlBinge eatingBinge-eating episodesPsychological treatmentPsychometric propertiesPsychometric studyTests of reliabilityBehavioral indicatorsAssessed adultsClinical researchPsychopathologyEatingRatersDisordersAudio-recordedAdultsPatient groupThe children of parents who receive treatment for binge‐eating disorder experience improvements in disordered eating
Lydecker J, Ozbardakci E, Grilo C. The children of parents who receive treatment for binge‐eating disorder experience improvements in disordered eating. International Journal Of Eating Disorders 2024, 57: 745-751. PMID: 38308384, PMCID: PMC10947894, DOI: 10.1002/eat.24153.Peer-Reviewed Original ResearchBinge-eating disorderBinge eatingDisordered eating behaviorsEating behaviorsSecretive eatingParent changesDisordered eatingAssociated with disordered eating behaviorsEating-disorder psychopathologyEnd-of-treatment assessmentParental eating disordersAssociated with changesChildren of parentsCross-sectional workChild disordered eating behaviorsBinge-eating frequencyEating disordersSchool-aged childrenParental treatmentUntreated family membersParent medicationLongitudinal researchBingeBaseline assessmentEating
2023
Transcranial Magnetic Stimulation for Reducing the Relative Reinforcing Value of Food in Adult Patients With Obesity Pursuing Metabolic and Bariatric Surgery: Protocol for a Pilot, Within-Participants, Sham-Controlled Trial
Bond D, Papasavas P, Raynor H, Grilo C, Steele V. Transcranial Magnetic Stimulation for Reducing the Relative Reinforcing Value of Food in Adult Patients With Obesity Pursuing Metabolic and Bariatric Surgery: Protocol for a Pilot, Within-Participants, Sham-Controlled Trial. JMIR Research Protocols 2023, 12: e50714. PMID: 37930756, PMCID: PMC10660230, DOI: 10.2196/50714.Peer-Reviewed Original ResearchRepetitive transcranial magnetic stimulationBrain reward processingRRV of foodTranscranial magnetic stimulationSham repetitive transcranial magnetic stimulationReward processingValue of foodMagnetic stimulationLeft dorsolateral prefrontal cortexNoninvasive brain stimulation techniqueINTERNATIONAL REGISTERED REPORT IDENTIFIERNeural reward circuitsSham-controlled crossover designFood reinforcementDorsolateral prefrontal cortexBrain stimulation techniquesSham rTMS conditionNeural measuresLine of researchActive repetitive transcranial magnetic stimulationFood rewardPrefrontal cortexPalatable foodReward circuitHigher food reinforcement
Clinical Trials
Current Trials
Treatments to Treat Loss-of-Control Eating and Improve Weight Outcomes after Bariatric Surgery
HIC ID2000029057RolePrincipal InvestigatorPrimary Completion Date11/30/2027Recruiting ParticipantsYale Dietary Supplement and Weight Management Study
HIC ID2000028769RoleSub InvestigatorPrimary Completion Date01/31/2026Recruiting ParticipantsGenderBothAge18 years - 55 yearsCognitive-Behavioral Therapy for Girls Who Experienced Weight-related Bullying
HIC ID2000028551RoleSub InvestigatorPrimary Completion Date08/31/2022Recruiting ParticipantsGenderFemaleAge11 years - 17 yearsTeen Binge Eating Study
HIC ID2000024926RoleSub InvestigatorPrimary Completion Date02/28/2020Recruiting ParticipantsGenderBothAge13 years - 17 years
News
News
- July 17, 2024Source: International Journal of Eating Disorders
Trauma-Focused Cognitive-Behavioral Therapy for Adolescents Bullied Because of Weight: A Feasibility Study
- April 12, 2024
Yurkow Honored For Best Original Research Paper By An Early Career Scholar
- March 27, 2024
Grilo Honored With Psychology Section's Sidney J. Blatt Award
- January 02, 2024Source: Cambridge University Press
Yale Researchers Test Efficacy of Naltrexone/Bupropion Maintenance Treatment for Binge Eating Disorder