2023
The Effects of Aging on Rod Bipolar Cell Ribbon Synapses
Shrestha A, Rameshkumar N, Boff J, Rajmanna R, Chandrasegaran T, Frederick C, Zenisek D, Vaithianathan T. The Effects of Aging on Rod Bipolar Cell Ribbon Synapses. Cells 2023, 12: 2385. PMID: 37830599, PMCID: PMC10572008, DOI: 10.3390/cells12192385.Peer-Reviewed Original ResearchConceptsRod bipolar cellsRibbon synapsesSynaptic ribbonsCalcium currentBipolar cellsRetinal ganglion cellsAge-related morphological changesBipolar cell ribbon synapsesBipolar cell terminalsGlobal health concernAge-related visual impairmentAge-related changesPlexiform layerGanglion cellsInner nuclearCochlear cellsSensory alterationsCell terminalsVisual impairmentFunctional changesHealth concernCalcium signalsSynapsesCalcium dynamicsRetina
2008
Melanopsin Ganglion Cells Use a Membrane-Associated Rhabdomeric Phototransduction Cascade
Graham DM, Wong KY, Shapiro P, Frederick C, Pattabiraman K, Berson DM. Melanopsin Ganglion Cells Use a Membrane-Associated Rhabdomeric Phototransduction Cascade. Journal Of Neurophysiology 2008, 99: 2522-2532. PMID: 18305089, DOI: 10.1152/jn.01066.2007.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiosensing TechniquesCalciumCell LineCell MembraneDiglyceridesEgtazic AcidElectrophysiologyEnzyme InhibitorsFluorescent Antibody TechniqueGTP-Binding ProteinsHeparinIn Vitro TechniquesInositol 1,4,5-Trisphosphate ReceptorsLight Signal TransductionMalePatch-Clamp TechniquesPC12 CellsPhotic StimulationProtein Kinase CRatsRats, Sprague-DawleyRetinal Ganglion CellsReverse Transcriptase Polymerase Chain ReactionRod OpsinsThapsigarginConceptsRhabdomeric photoreceptorsCommon evolutionary originEvolutionary originPlasma membraneInvertebrate eyesG proteinsPhototransduction cascadePhototransduction mechanismPhospholipase C.Single-cell RT-PCRMammalian eyePhotoreceptorsCascadeRT-PCRCircadian rhythmCellsStriking similarityMembranePatch-clamp recordingsPhototransductionOpsinProteinPhotopigmentsMelanopsinGanglion cells