Melanopsin Ganglion Cells Use a Membrane-Associated Rhabdomeric Phototransduction Cascade
Graham DM, Wong KY, Shapiro P, Frederick C, Pattabiraman K, Berson DM. Melanopsin Ganglion Cells Use a Membrane-Associated Rhabdomeric Phototransduction Cascade. Journal Of Neurophysiology 2008, 99: 2522-2532. PMID: 18305089, DOI: 10.1152/jn.01066.2007.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiosensing TechniquesCalciumCell LineCell MembraneDiglyceridesEgtazic AcidElectrophysiologyEnzyme InhibitorsFluorescent Antibody TechniqueGTP-Binding ProteinsHeparinIn Vitro TechniquesInositol 1,4,5-Trisphosphate ReceptorsLight Signal TransductionMalePatch-Clamp TechniquesPC12 CellsPhotic StimulationProtein Kinase CRatsRats, Sprague-DawleyRetinal Ganglion CellsReverse Transcriptase Polymerase Chain ReactionRod OpsinsThapsigarginConceptsRhabdomeric photoreceptorsCommon evolutionary originEvolutionary originPlasma membraneInvertebrate eyesG proteinsPhototransduction cascadePhototransduction mechanismPhospholipase C.Single-cell RT-PCRMammalian eyePhotoreceptorsCascadeRT-PCRCircadian rhythmCellsStriking similarityMembranePatch-clamp recordingsPhototransductionOpsinProteinPhotopigmentsMelanopsinGanglion cells