2024
Matching-Adjusted Indirect Comparison of Risankizumab Versus Deucravacitinib in Patients with Moderate-to-Severe Plaque Psoriasis
Armstrong A, Soliman A, Gisondi P, Fang S, Patel M, Strober B. Matching-Adjusted Indirect Comparison of Risankizumab Versus Deucravacitinib in Patients with Moderate-to-Severe Plaque Psoriasis. Dermatology And Therapy 2024, 1-11. PMID: 39453596, DOI: 10.1007/s13555-024-01293-y.Peer-Reviewed Original ResearchDermatology Life Quality IndexSkin clearanceIndirect comparisonsStatic Physician's Global AssessmentRisankizumab-treated patientsPhysician global assessmentTreatment of psoriasisMatching-adjusted indirect comparisonIndividual patient dataLife Quality IndexPlaque psoriasisPsoriasis AreaRisankizumabDeucravacitinibNew therapiesIntroductionDespite advancesPsO.Global assessmentQuality of lifePsoriasisPatientsPropensity scorePatient dataClearanceHealthcare providers54131 Malignancy Rates in Patients With a History of Malignancy in the Psoriasis Longitudinal Assessment and Registry (PSOLAR)
Langley R, Fiorentino D, Bagel J, Lafferty K, Skobelev E, Langholff W, Lebwohl M, Ho V, Strober B. 54131 Malignancy Rates in Patients With a History of Malignancy in the Psoriasis Longitudinal Assessment and Registry (PSOLAR). Journal Of The American Academy Of Dermatology 2024, 91: ab61. DOI: 10.1016/j.jaad.2024.07.252.Peer-Reviewed Original Research52671 Bimekizumab safety and tolerability in moderate to severe plaque psoriasis: Pooled analysis from up to 4 years of treatment in 5 phase 3/3b clinical trials
Gordon K, Thaçi D, Gooderham M, Okubo Y, Strober B, Peterson L, Deherder D, Pinto J, Gisondi P. 52671 Bimekizumab safety and tolerability in moderate to severe plaque psoriasis: Pooled analysis from up to 4 years of treatment in 5 phase 3/3b clinical trials. Journal Of The American Academy Of Dermatology 2024, 91: ab145. DOI: 10.1016/j.jaad.2024.07.577.Peer-Reviewed Original Research51856 Spesolimab rapidly improves quality of life in patients with generalized pustular psoriasis, as per Dermatology Life Quality Index scores: Data from the Effisayil 2 trial
Gottlieb A, Strober B, Kokolakis G, Merola J, Zheng M, Langley R, Tang M, Hofmann P, Thoma C, Warren R. 51856 Spesolimab rapidly improves quality of life in patients with generalized pustular psoriasis, as per Dermatology Life Quality Index scores: Data from the Effisayil 2 trial. Journal Of The American Academy Of Dermatology 2024, 91: ab316. DOI: 10.1016/j.jaad.2024.07.1256.Peer-Reviewed Original Research52875 Integrated cardiovascular safety analysis of ritlecitinib in patients with alopecia areata (AA) in the phase 2 and phase 3 ALLEGRO clinical trials, and contextualization with a US cohort of patients with AA
Sicco K, Soung J, Strober B, Irvine A, Wajsbrot D, Gromek K, Wolk R, Barnes D, Takiya L. 52875 Integrated cardiovascular safety analysis of ritlecitinib in patients with alopecia areata (AA) in the phase 2 and phase 3 ALLEGRO clinical trials, and contextualization with a US cohort of patients with AA. Journal Of The American Academy Of Dermatology 2024, 91: ab55. DOI: 10.1016/j.jaad.2024.07.228.Peer-Reviewed Original Research54148 Characteristics of Real-world Patients With Psoriasis Prescribed Guselkumab or Interleukin-17 Inhibitors: Data From the Psoriasis Longitudinal Assessment and Registry (PSOLAR)
Strober B, Augustin M, Tada Y, Lafferty K, Skobelev E, Langholff W, Fakharzadeh S, Gniadecki R. 54148 Characteristics of Real-world Patients With Psoriasis Prescribed Guselkumab or Interleukin-17 Inhibitors: Data From the Psoriasis Longitudinal Assessment and Registry (PSOLAR). Journal Of The American Academy Of Dermatology 2024, 91: ab152. DOI: 10.1016/j.jaad.2024.07.605.Peer-Reviewed Original Research51447 Long Term Real-World Achievement of Skin Clearance Treatment Targets and Maintenance of Response with Risankizumab in Patients with Moderate to Severe Psoriasis: 2-year Results from the CorEvitas Psoriasis Registry
Armstrong A, Ferris L, Callis-Duffin K, Sima A, Eckmann T, Beeghly A, Photowala H, Patel M, Garg V, Strober B. 51447 Long Term Real-World Achievement of Skin Clearance Treatment Targets and Maintenance of Response with Risankizumab in Patients with Moderate to Severe Psoriasis: 2-year Results from the CorEvitas Psoriasis Registry. Journal Of The American Academy Of Dermatology 2024, 91: ab59. DOI: 10.1016/j.jaad.2024.07.244.Peer-Reviewed Original Research52284 Influence of Biological Sex on Clinical Manifestation in Moderate-to-Severe Atopic Dermatitis and on Dupilumab Treatment Effectiveness
Zink A, Beck L, Lebwohl M, Gooderham M, Strober B, Maul J, Pinter A, Johansson E, Chen Z, Hagen S, Bastian M. 52284 Influence of Biological Sex on Clinical Manifestation in Moderate-to-Severe Atopic Dermatitis and on Dupilumab Treatment Effectiveness. Journal Of The American Academy Of Dermatology 2024, 91: ab240. DOI: 10.1016/j.jaad.2024.07.952.Peer-Reviewed Original Research50857 Treatment Discontinuation Patterns in Patients With Psoriasis Receiving Apremilast in North America: A Registry-Based Analysis
Strober B, Zhong Y, Varga S, Napoli A, Sima A, Beeghly A, Zhuo J. 50857 Treatment Discontinuation Patterns in Patients With Psoriasis Receiving Apremilast in North America: A Registry-Based Analysis. Journal Of The American Academy Of Dermatology 2024, 91: ab93. DOI: 10.1016/j.jaad.2024.07.377.Peer-Reviewed Original Research51099 Real-world application of the International Psoriasis Council guidelines for prescribing systemic treatment to patients with psoriasis in North America
Strober B, Zhong Y, Beeghly A, Eckmann T, Balagula E, Zhuo J, Lebwohl M. 51099 Real-world application of the International Psoriasis Council guidelines for prescribing systemic treatment to patients with psoriasis in North America. Journal Of The American Academy Of Dermatology 2024, 91: ab293. DOI: 10.1016/j.jaad.2024.07.1164.Peer-Reviewed Original Research54001 Efficacy of Risankizumab for Moderate-to-Severe Plaque Psoriasis Through 304 Weeks: Subgroup Analysis by Baseline Demographics and Disease Characteristics From the LIMMitless Trial
Strober B, Wu T, Photowala H, Chen M, Bachelez H. 54001 Efficacy of Risankizumab for Moderate-to-Severe Plaque Psoriasis Through 304 Weeks: Subgroup Analysis by Baseline Demographics and Disease Characteristics From the LIMMitless Trial. Journal Of The American Academy Of Dermatology 2024, 91: ab37. DOI: 10.1016/j.jaad.2024.07.157.Peer-Reviewed Original Research52675 Bimekizumab efficacy across subgroups of patients with moderate to severe plaque psoriasis: Pooled analysis from up to 3 years of treatment in 5 phase 3/3b clinical trials
Strober B, Krueger J, Magnolo N, Vender R, Boehncke W, Hong H, Tilt N, Staelens F, Wiegratz S, Paul C. 52675 Bimekizumab efficacy across subgroups of patients with moderate to severe plaque psoriasis: Pooled analysis from up to 3 years of treatment in 5 phase 3/3b clinical trials. Journal Of The American Academy Of Dermatology 2024, 91: ab142. DOI: 10.1016/j.jaad.2024.07.572.Peer-Reviewed Original Research51349 Spesolimab for the prevention of generalized pustular psoriasis (GPP) flares in White/Caucasian patients: Results from the randomized, placebo-controlled Effisayil 2 study
Strober B, Warren R, Gordon K, Langley R, Lebwohl M, Puig L, Tang M, Radic T, Hofmann P, Thoma C, Thaçi D. 51349 Spesolimab for the prevention of generalized pustular psoriasis (GPP) flares in White/Caucasian patients: Results from the randomized, placebo-controlled Effisayil 2 study. Journal Of The American Academy Of Dermatology 2024, 91: ab87. DOI: 10.1016/j.jaad.2024.07.354.Peer-Reviewed Original Research51342 Four-weekly dosing intervals with subcutaneous spesolimab appear to be required for optimal prevention of generalized pustular psoriasis flares: Data from the Effisayil 2 and Effisayil ON trials
Thaçi D, Morita A, Strober B, Torres T, Pinter A, Marzano A, Krueger J, Tang M, Hofmann P, Thoma C, Lebwohl M. 51342 Four-weekly dosing intervals with subcutaneous spesolimab appear to be required for optimal prevention of generalized pustular psoriasis flares: Data from the Effisayil 2 and Effisayil ON trials. Journal Of The American Academy Of Dermatology 2024, 91: ab46. DOI: 10.1016/j.jaad.2024.07.192.Peer-Reviewed Original Research50668 Long-term Impact of Apremilast on Cardiometabolic Parameters and the Relationship of Cardiometabolic Changes With Psoriasis Efficacy
Strober B, Crowley J, Langley R, Deignan C, Teng L, Zhou Z, Mehta N. 50668 Long-term Impact of Apremilast on Cardiometabolic Parameters and the Relationship of Cardiometabolic Changes With Psoriasis Efficacy. Journal Of The American Academy Of Dermatology 2024, 91: ab60. DOI: 10.1016/j.jaad.2024.07.245.Peer-Reviewed Original ResearchRisk of Developing Inflammatory Arthritis in Psoriasis Patients Initiating Treatment With Biologics: A Population Based Analysis
Strober B, Soliman A, Li C, Patel M, Unigwe I, Gisondi P. Risk of Developing Inflammatory Arthritis in Psoriasis Patients Initiating Treatment With Biologics: A Population Based Analysis. Journal Of The American Academy Of Dermatology 2024 PMID: 39197499, DOI: 10.1016/j.jaad.2024.06.106.Peer-Reviewed Original ResearchIL-23 inhibitorsDevelopment of inflammatory arthritisIL-23IL-17Inflammatory arthritisPsO patientsTNF inhibitorsMultivariate Cox proportional hazards modelDiagnosis of inflammatory arthritisPatients initiate treatmentCox proportional hazards modelsData Mart DatabaseAdjusted hazard ratiosProportional hazards modelIL-12/23Hazard ratioLow riskPatientsProtopathic biasBaseline diagnosisIncidence rateHazards modelArthritisTNFEffect of biological treatmentLB946 Spesolimab controls chronic inflammation in GPP
Krueger J, Gudjonsson J, Morita A, Lebwohl M, Warren R, Mostaghimi A, Langley R, Tang M, Visvanathan S, Thoma C, Strober B. LB946 Spesolimab controls chronic inflammation in GPP. Journal Of Investigative Dermatology 2024, 144: s165. DOI: 10.1016/j.jid.2024.06.1119.Peer-Reviewed Original ResearchBimekizumab Safety and Tolerability in Moderate to Severe Plaque Psoriasis: Pooled Analysis from Up to 4 Years of Treatment in 5 Phase 3/3b Clinical Trials
Gordon K, Thaçi D, Gooderham M, Okubo Y, Strober B, Peterson L, Deherder D, López Pinto J, Gisondi P. Bimekizumab Safety and Tolerability in Moderate to Severe Plaque Psoriasis: Pooled Analysis from Up to 4 Years of Treatment in 5 Phase 3/3b Clinical Trials. SKIN The Journal Of Cutaneous Medicine 2024, 8: s404. DOI: 10.25251/skin.8.supp.404.Peer-Reviewed Original ResearchTreatment-emergent adverse eventsSevere plaque psoriasisOpen-label extensionPlaque psoriasisOral candidiasisPatient yrModerate to severe plaque psoriasisUpper respiratory tract infectionLong-term safety of treatmentRespiratory tract infectionsNext scheduled visitYear of treatmentSafety of treatmentLong-term safetySafety findingsTract infectionsLong-term managementBimekizumabSafety profileAdverse eventsPooled analysisClinical trialsQ8WSafety dataPsoriasisSpesolimab Rapidly Improves Quality of Life in Patients with Generalized Pustular Psoriasis, as per Dermatology Life Quality Index Scores: Data from the Effisayil 2 Trial
Gottlieb A, Strober B, Kokolakis G, Merola J, Zheng M, Langley R, Tang M, Hofmann P, Thoma C, Warren R. Spesolimab Rapidly Improves Quality of Life in Patients with Generalized Pustular Psoriasis, as per Dermatology Life Quality Index Scores: Data from the Effisayil 2 Trial. SKIN The Journal Of Cutaneous Medicine 2024, 8: s409. DOI: 10.25251/skin.8.supp.409.Peer-Reviewed Original ResearchGeneralized pustular psoriasisDermatology Life Quality IndexDermatology Life Quality Index scoresGeneralized pustular psoriasis flaresPustular psoriasisVisits up to weekWeek 4Results Baseline characteristicsLength of diseaseLife Quality IndexLife-threatening diseasePlacebo groupHigh-doseSkin pustulesBaseline characteristicsSpesolimabFlare preventionPlaceboDLQI scoreQuality of lifePatientsWeeksPsoriasisScoresDiseaseDeucravacitinib in Plaque Psoriasis: 4-Year Safety and Efficacy Results From the Phase 3 POETYK PSO-1, PSO-2, and LTE Trials
Armstrong A, Lebwohl M, Warren R, Sofen H, Morita A, Imafuku S, Ohtsuki M, Spelman L, Passeron T, Papp K, Colombo M, Vaile J, Vritzali E, Hoyt K, Daamen C, Banerjee S, Strober B, Thaçi D, Blauvelt A. Deucravacitinib in Plaque Psoriasis: 4-Year Safety and Efficacy Results From the Phase 3 POETYK PSO-1, PSO-2, and LTE Trials. SKIN The Journal Of Cutaneous Medicine 2024, 8: s406. DOI: 10.25251/skin.8.supp.406.Peer-Reviewed Original ResearchAssess adverse eventsLong-term extensionModerate to severe plaque psoriasisExposure-adjusted incidence ratesSevere plaque psoriasisPlaque psoriasisLong-term extension trialsClinical response rateTreatment of adultsSystemic therapyEfficacy outcomesHerpes zosterSafety profileVenous thromboembolismAdverse eventsDeucravacitinibEfficacy resultsSafety signalsPatientsContinuous treatmentResponse rateIncidence rateParent trialPsoriasisAllosteric TYK2 inhibitor