Super‐response to guselkumab treatment in patients with moderate‐to‐severe psoriasis: age, body weight, baseline Psoriasis Area and Severity Index, and baseline Investigator's Global Assessment scores predict complete skin clearance
Reich K, Gordon K, Strober B, Langley R, Miller M, Yang Y, Shen Y, You Y, Zhu Y, Foley P, Blauvelt A. Super‐response to guselkumab treatment in patients with moderate‐to‐severe psoriasis: age, body weight, baseline Psoriasis Area and Severity Index, and baseline Investigator's Global Assessment scores predict complete skin clearance. Journal Of The European Academy Of Dermatology And Venereology 2022, 36: 2393-2400. PMID: 35920762, DOI: 10.1111/jdv.18474.Peer-Reviewed Original ResearchConceptsGlobal assessment scoreInvestigator's Global Assessment scoreSevere psoriasisGuselkumab treatmentChronic immune-mediated inflammatory skin diseaseBody weightImmune-mediated inflammatory skin diseaseAssessment scoresStepwise logistic regression analysisBaseline Psoriasis AreaComplete skin clearanceEarly clinical responseLess obese patientsVOYAGE 2 studiesBaseline body weightSubset of patientsInflammatory skin diseaseLogistic regression analysisHuman monoclonal antibodyPASI 100PASI 75Skin clearanceBaseline characteristicsBaseline demographicsClinical responseA Practical Guide to the Management of Oral Candidiasis in Patients with Plaque Psoriasis Receiving Treatments That Target Interleukin-17
Armstrong A, Blauvelt A, Mrowietz U, Strober B, Gisondi P, Merola J, Langley R, Ståhle M, Lebwohl M, Netea M, Nunez Gomez N, Warren R. A Practical Guide to the Management of Oral Candidiasis in Patients with Plaque Psoriasis Receiving Treatments That Target Interleukin-17. Dermatology And Therapy 2022, 12: 787-800. PMID: 35167107, PMCID: PMC8941045, DOI: 10.1007/s13555-022-00687-0.Peer-Reviewed Original ResearchIL-23/ILOral candidiasisImmune-mediated inflammatory skin diseaseCo-existing diabetesGood oral hygieneInflammatory skin diseaseDysregulation of cytokinesStandard antifungal therapyAntifungal host defensePlaque psoriasisBiologic therapyInterleukin-17Oral hygieneAntifungal therapyPsoriasisPatientsSkin diseasesCandidiasisHost defenseFungal infectionsCytokinesTherapyTreatmentILPractical guide