2014
Increasing stimulus duration can normalize late-positive event related potentials in people with schizophrenia: Possible implications for understanding cognitive deficits
Wexler BE, Ikezawa S, Corbera S. Increasing stimulus duration can normalize late-positive event related potentials in people with schizophrenia: Possible implications for understanding cognitive deficits. Schizophrenia Research 2014, 158: 163-169. PMID: 25096541, PMCID: PMC4240766, DOI: 10.1016/j.schres.2014.07.012.Peer-Reviewed Original ResearchConceptsHealthy controlsCognitive deficitsMs stimuliStructured Clinical InterviewDSM-IV criteriaModulation of responsesStimulus durationPictures of handsEvent Related PotentialsAdult outpatientsPain stimuliHealthy peoplePatientsClinical InterviewSchizoaffective disorderSchizophreniaMs stimulusSensory inputStimulus onsetSame durationDurationStimuliDeficitsResponseNeutral stimuli
2012
A pilot and feasibility study of computer-based training for visual processing deficits in schizophrenia
Surti TS, Wexler BE. A pilot and feasibility study of computer-based training for visual processing deficits in schizophrenia. Schizophrenia Research 2012, 142: 248-249. PMID: 23043873, DOI: 10.1016/j.schres.2012.09.013.Peer-Reviewed Original Research
2011
Successful computer-based visual training specifically predicts visual memory enhancement over verbal memory improvement in schizophrenia
Surti TS, Corbera S, Bell MD, Wexler BE. Successful computer-based visual training specifically predicts visual memory enhancement over verbal memory improvement in schizophrenia. Schizophrenia Research 2011, 132: 131-134. PMID: 21795025, PMCID: PMC3195942, DOI: 10.1016/j.schres.2011.06.031.Peer-Reviewed Original ResearchConceptsCognitive remediationCognitive control trainingEarly visual processingVerbal memory improvementVerbal learningAuditory learningVisual learningCognitive gainsVisual processingMemory enhancementVisual trainingCognitive outcomesMemory improvementControl trainingNeuropsychological testingVisual informationMultiple modalitiesTraining exercisesLearningInformation manipulationTrainingSchizophreniaGeneralizesTaskParticipants
2006
Neuropsychological deficits in nonsmokers with schizophrenia: Effects of a nicotinic antagonist
Sacco KA, Termine A, Dudas MM, Seyal AA, Allen TM, Vessicchio JC, Wexler BE, George TP. Neuropsychological deficits in nonsmokers with schizophrenia: Effects of a nicotinic antagonist. Schizophrenia Research 2006, 85: 213-221. PMID: 16678390, DOI: 10.1016/j.schres.2006.03.025.Peer-Reviewed Original ResearchConceptsWisconsin Card Sorting TestContinuous Performance TestControl nonsmokersNeuropsychological performanceStroop Color-Word TestNeuropsychological deficitsNicotinic acetylcholine receptor systemAcetylcholine receptor systemPosition testVisuospatial working memoryCigarette smokingAntagonist mecamylamineNicotinic antagonistsNeuropsychological dysfunctionNAChR blockadeNonsmokersSchizophrenia diagnosisColor-Word TestMecamylamineReceptor systemNeuropsychological assessmentSchizophreniaCard Sorting TestCounterbalanced designTest week
2003
Amygdala hyperreactivity in borderline personality disorder: implications for emotional dysregulation
Donegan NH, Sanislow CA, Blumberg HP, Fulbright RK, Lacadie C, Skudlarski P, Gore JC, Olson IR, McGlashan TH, Wexler BE. Amygdala hyperreactivity in borderline personality disorder: implications for emotional dysregulation. Biological Psychiatry 2003, 54: 1284-1293. PMID: 14643096, DOI: 10.1016/s0006-3223(03)00636-x.Peer-Reviewed Original ResearchConceptsNormal control subjectsBorderline personality disorderControl subjectsBorderline patientsAmygdala hyperreactivityBPD patientsPersonality disorderEmotional dysregulationDisorders of moodFunctional magnetic resonance imagingMagnetic resonance imagingClinical research teamPatientsResonance imagingPsychiatry departmentDSM-IVAmygdala reactivityAmygdala activationDisordersNeural responsesHyperreactivityDysregulationActivation levelsSubjectsRobust differences
2001
Functional Magnetic Resonance Imaging of Cocaine Craving
Wexler BE, Gottschalk CH, Fulbright RK, Prohovnik I, Lacadie CM, Rounsaville BJ, Gore JC. Functional Magnetic Resonance Imaging of Cocaine Craving. American Journal Of Psychiatry 2001, 158: 86-95. PMID: 11136638, DOI: 10.1176/appi.ajp.158.1.86.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingHealthy subjectsCocaine-dependent subjectsMagnetic resonance imagingResonance imagingCocaine addictsReported onsetBrain activationBrain activityRegional brain activationFrontal lobe activationAnterior cingulate activationNeurobiology of addictionCocaine cravingAnterior cingulatePatientsFrontal lobePhysiologic linkSensory areasComparison of groupsDrug cravingDysphoric statesLess activationGeneral abnormalityCingulate activation
1995
Functional significance of individual variations in callosal area
Yazgan M, Wexler B, Kinsbourne M, Peterson B, Leckman J. Functional significance of individual variations in callosal area. Neuropsychologia 1995, 33: 769-779. PMID: 7675166, DOI: 10.1016/0028-3932(95)00018-x.Peer-Reviewed Original ResearchConceptsCallosal areaCorpus callosumMidsagittal cross-sectional areaDual-task interferenceDual-task performanceTime-sharing abilityBehavioral lateralityInterhemispheric connectionsWord listeningTask interferenceLine bisectionNormal adultsCross-sectional areaHemisphere conditionsBias testCallosumLateralityNormal variationFunctional significanceIndividual variation
1993
Asymmetrical Visual Deprivation: A Technique to Differentially Influence Lateral Hemispheric Function
Levick S, Wexler B, Lorig T, Gur R, Gur R, Schwartz G. Asymmetrical Visual Deprivation: A Technique to Differentially Influence Lateral Hemispheric Function. Perceptual And Motor Skills 1993, 76: 1363-1382. PMID: 8337093, DOI: 10.2466/pms.1993.76.3c.1363.Peer-Reviewed Original ResearchConceptsVisual deprivationHemispheric functionCross-modal influencesSpatial orientation taskPerception of pleasantnessLine bisection testVisual attentionVerbal reasoningContact lens methodIntegrated brainOrientation taskLeft hemisphereMood statesEEG thetaMore thetaLateral asymmetryActivation balanceGeneral hypothesisThetaPleasantnessDeprivationHemisphereInput deprivationPerceptionTask