2012
Computerized cognitive remediation training for schizophrenia: An open label, multi-site, multinational methodology study
Murthy NV, Mahncke H, Wexler BE, Maruff P, Inamdar A, Zucchetto M, Lund J, Shabbir S, Shergill S, Keshavan M, Kapur S, Laruelle M, Alexander R. Computerized cognitive remediation training for schizophrenia: An open label, multi-site, multinational methodology study. Schizophrenia Research 2012, 139: 87-91. PMID: 22342330, DOI: 10.1016/j.schres.2012.01.042.Peer-Reviewed Original ResearchConceptsFunctional capacity outcome measuresCognitive Assessment InterviewBrain Fitness ProgramSignificant treatment effectOutcome measuresRegular antipsychotic medicationStable adult patientsNon-pharmacological methodsCognitive performanceTreatment effectsComputerized cognitive remediation trainingMultinational clinical trialsSingle-site studyTraining effectsCognitive remediation trainingOpen labelAdult patientsAntipsychotic medicationCAI scoreClinical trialsCognitive impairmentMulti-site studyExercise taskRemediation trainingNeuropsychological tasks
2005
Differences in performance and learning proficiency on the Wisconsin Card Sorting Test in schizophrenia: Do they reflect distinct neurocognitive subtypes with distinct functional profiles?
Kurtz MM, Wexler BE. Differences in performance and learning proficiency on the Wisconsin Card Sorting Test in schizophrenia: Do they reflect distinct neurocognitive subtypes with distinct functional profiles? Schizophrenia Research 2005, 81: 167-171. PMID: 16243489, DOI: 10.1016/j.schres.2005.09.003.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAdultAttentionCognition DisordersCuesDiscrimination LearningFemaleHumansLearning DisabilitiesMaleMemory, Short-TermMiddle AgedNeuropsychological TestsPractice, PsychologicalProblem SolvingPsychometricsPsychomotor PerformanceReaction TimeSchizophreniaSchizophrenic PsychologyConceptsWisconsin Card Sorting TestUCSD Performance-based Skills AssessmentCard Sorting TestSorting TestComprehensive neurocognitive test batteryPerformance-Based Skills AssessmentDifferent neurocognitive profilesNeurocognitive test batteryPerformance-based measuresBehavioral treatment interventionsSecond measureNeurocognitive subtypesNeurocognitive profileMotor sequencingWCST performancePoor learnersTest batteryGood learnersDistinct functional profilesSubtyping of patientsTreatment interventionsIndependent measuresLearnersSkills assessmentGreater functional capacity
2000
Preliminary Evidence of Improved Verbal Working Memory Performance and Normalization of Task-Related Frontal Lobe Activation in Schizophrenia Following Cognitive Exercises
Wexler BE, Anderson M, Fulbright RK, Gore JC. Preliminary Evidence of Improved Verbal Working Memory Performance and Normalization of Task-Related Frontal Lobe Activation in Schizophrenia Following Cognitive Exercises. American Journal Of Psychiatry 2000, 157: 1694-1697. PMID: 11007730, DOI: 10.1176/appi.ajp.157.10.1694.Peer-Reviewed Original ResearchConceptsLeft inferior frontal cortexTask-related activationVerbal memory taskInferior frontal cortexMemory performanceMemory taskCognitive exercisesMemory exercisesNonverbal memory performanceWorking Memory PerformanceVerbal memory deficitsVerbal memory dysfunctionFrontal lobe activationRegional brain activationFrontal cortexSame brain regionsBrain activationTraining periodMemory deficitsMemory dysfunctionBrain regionsPreliminary evidenceBehavioral aspectsTaskSchizophrenia