2016
Restless Legs Syndrome and Depression: Effect Mediation by Disturbed Sleep and Periodic Limb Movements
Koo BB, Blackwell T, Lee HB, Stone KL, Louis ED, Redline S, Group O. Restless Legs Syndrome and Depression: Effect Mediation by Disturbed Sleep and Periodic Limb Movements. American Journal Of Geriatric Psychiatry 2016, 24: 1105-1116. PMID: 27526989, PMCID: PMC5241001, DOI: 10.1016/j.jagp.2016.04.003.Peer-Reviewed Original ResearchConceptsSevere restless legs syndromeRestless legs syndromePeriodic limb movementsDepressive symptomsLegs syndromeSleep disturbancesMild restless legs syndromeFurther adjustmentAssociation of RLSLimb movementsCardiovascular risk factorsApnea-hypopnea indexBody mass indexPotential mediatorsCross-sectional analysisEffect sizeDopaminergic medicationMass indexOsteoporotic fracturesPLMS indexDisturbed sleepRisk factorsGDS scoresPhysical activitySleep efficiency
2014
Periodic Limb Movements During Sleep and Prevalent Hypertension in the Multi-Ethnic Study of Atherosclerosis
Koo BB, Sillau S, Dean DA, Lutsey PL, Redline S. Periodic Limb Movements During Sleep and Prevalent Hypertension in the Multi-Ethnic Study of Atherosclerosis. Hypertension 2014, 65: 70-77. PMID: 25287399, PMCID: PMC4268086, DOI: 10.1161/hypertensionaha.114.04193.Peer-Reviewed Original ResearchConceptsSystolic blood pressurePLMS-arousal indexPeriodic limb movementsPrevalent hypertensionBlood pressureOverall cohortPLMS indexArousal indexObserved systolic blood pressureLimb movementsCardiovascular risk factorsBlood pressure outcomesApnea-hypopnea indexCommunity-dwelling menBody mass indexType/doseMulti-Ethnic StudyRace/ethnicityAntihypertensive medicationsPLMS frequencyDiastolic BPMass indexPressure outcomesRisk factorsSBP values
2011
Association of Incident Cardiovascular Disease With Periodic Limb Movements During Sleep in Older Men
Koo BB, Blackwell T, Ancoli-Israel S, Stone KL, Stefanick ML, Redline S, Group F. Association of Incident Cardiovascular Disease With Periodic Limb Movements During Sleep in Older Men. Circulation 2011, 124: 1223-1231. PMID: 21859975, PMCID: PMC3265562, DOI: 10.1161/circulationaha.111.038968.Peer-Reviewed Original ResearchConceptsCause cardiovascular diseaseCoronary heart diseasePeripheral arterial diseaseIncident cardiovascular diseasePeriodic limb movementsArterial diseaseCardiovascular diseaseCerebrovascular diseaseHeart diseasePLMS frequencyRelative hazardCommunity-dwelling elderly menConventional cardiovascular risk factorsPeripheral arterial disease eventsLimb movementsElderly male cohortCardiovascular risk factorsBody mass indexProportional hazards regressionRisk of incidentPrevalent hypertensionCardiovascular riskMass indexStudy cohortHazards regression