2023
High-throughput functional analysis of autism genes in zebrafish identifies convergence in dopaminergic and neuroimmune pathways
Mendes H, Neelakantan U, Liu Y, Fitzpatrick S, Chen T, Wu W, Pruitt A, Jin D, Jamadagni P, Carlson M, Lacadie C, Enriquez K, Li N, Zhao D, Ijaz S, Sakai C, Szi C, Rooney B, Ghosh M, Nwabudike I, Gorodezky A, Chowdhury S, Zaheer M, McLaughlin S, Fernandez J, Wu J, Eilbott J, Vander Wyk B, Rihel J, Papademetris X, Wang Z, Hoffman E. High-throughput functional analysis of autism genes in zebrafish identifies convergence in dopaminergic and neuroimmune pathways. Cell Reports 2023, 42: 112243. PMID: 36933215, PMCID: PMC10277173, DOI: 10.1016/j.celrep.2023.112243.Peer-Reviewed Original ResearchConceptsGene lossFunctional analysisHigh-throughput functional analysisZebrafish mutantsGene discoverySelect mutantsASD genesAutism genesKey pathwaysASD biologyBrain size differencesMutantsGenesSize differencesPathwayGlobal increaseRelevant mechanismsBiologyCentral challengeNeuroimmune dysfunctionRegionFunctionDiscoveryAutism spectrum disorder
2017
Neurogenetic analysis of childhood disintegrative disorder
Gupta AR, Westphal A, Yang DYJ, Sullivan CAW, Eilbott J, Zaidi S, Voos A, Vander Wyk BC, Ventola P, Waqar Z, Fernandez TV, Ercan-Sencicek AG, Walker MF, Choi M, Schneider A, Hedderly T, Baird G, Friedman H, Cordeaux C, Ristow A, Shic F, Volkmar FR, Pelphrey KA. Neurogenetic analysis of childhood disintegrative disorder. Molecular Autism 2017, 8: 19. PMID: 28392909, PMCID: PMC5379515, DOI: 10.1186/s13229-017-0133-0.Peer-Reviewed Original ResearchAdaptor Proteins, Signal TransducingAutism Spectrum DisorderBasic Helix-Loop-Helix Transcription FactorsBrainBrain MappingCase-Control StudiesChildChild, PreschoolChromosomes, Human, XDisease ProgressionDNA Copy Number VariationsExome SequencingFemaleGene ExpressionHumansIntellectual DisabilityMagnetic Resonance ImagingMaleMaternal InheritanceNuclear ProteinsPhenotypePolymorphism, GeneticSeverity of Illness IndexSiblingsTranscription FactorsTranscriptome
2016
Intranasal Oxytocin Enhances Connectivity in the Neural Circuitry Supporting Social Motivation and Social Perception in Children with Autism
Gordon I, Jack A, Pretzsch CM, Vander Wyk B, Leckman JF, Feldman R, Pelphrey KA. Intranasal Oxytocin Enhances Connectivity in the Neural Circuitry Supporting Social Motivation and Social Perception in Children with Autism. Scientific Reports 2016, 6: 35054. PMID: 27845765, PMCID: PMC5109935, DOI: 10.1038/srep35054.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderIntranasal oxytocinSocial motivationSocial perceptionSocial-emotional informationFunctional magnetic resonance imagingPlacebo-controlled crossover designBiological motionSocial stimuliAngry voicesSocial deficitsSpectrum disorderOT administrationMesolimbic reward pathwayBehavioral treatmentBrain rewardReduced connectivityBrain regionsReward pathwayCortical sitesRewardPerceptionMotivationOxytocinBrain sites
2015
Unlike adults, children and adolescents show predominantly increased neural activation to social exclusion by members of the opposite gender
Bolling DZ, Pelphrey KA, Vander Wyk B. Unlike adults, children and adolescents show predominantly increased neural activation to social exclusion by members of the opposite gender. Social Neuroscience 2015, 11: 475-486. PMID: 26592311, PMCID: PMC4976300, DOI: 10.1080/17470919.2015.1117019.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingNeural correlatesGroup membershipOnline ball-tossing gameSocial exclusionAnterior cingulate responsesBall-tossing gameSocial anxiety disorderOpposite genderSocio-emotional developmentDifferential neural correlatesAnterior cingulate cortexPrevious adult studiesPeer rejectionCingulate responseBrain responsesPeer relationsNeural activationAnxiety disordersCingulate cortexMain effectCurrent studyAdolescenceIncreased activationAdolescents
2014
Altered brain connectivity in sagittal craniosynostosis.
Beckett JS, Brooks ED, Lacadie C, Wyk B, Jou RJ, Steinbacher DM, Constable RT, Pelphrey KA, Persing JA. Altered brain connectivity in sagittal craniosynostosis. Journal Of Neurosurgery Pediatrics 2014, 13: 690-8. PMID: 24745341, DOI: 10.3171/2014.3.peds13516.Peer-Reviewed Original ResearchConceptsDiffusion tensor imagingPosterior cingulate cortexCingulate cortexSagittal nonsyndromic craniosynostosisPrefrontal cortexRight posterior cingulate cortexBrodmann area 8Functional connectivity differencesRight middle frontal gyrusWhite matter alterationsAnterior cingulate cortexBrodmann area 7Left ventromedial prefrontal cortexAltered brain connectivityResting-state functional connectivity MRI dataMiddle frontal gyrusRight supramarginal gyrusDefault mode networkIntrinsic connectivity analysesSignificant group differencesAdolescent patientsAltered connectivityNeurocognitive morbidityHigh prevalenceRight parahippocampus
2013
Social, reward, and attention brain networks are involved when online bids for joint attention are met with congruent versus incongruent responses
Gordon I, Eilbott JA, Feldman R, Pelphrey KA, Vander Wyk B. Social, reward, and attention brain networks are involved when online bids for joint attention are met with congruent versus incongruent responses. Social Neuroscience 2013, 8: 544-554. PMID: 24044427, DOI: 10.1080/17470919.2013.832374.Peer-Reviewed Original ResearchConceptsJoint attentionTemporoparietal junctionIncongruent responsesFMRI paradigmFunctional magnetic resonance imaging (fMRI) researchDorsal anterior cingulate cortexNaturalistic fMRI paradigmsHuman social functioningImpact of congruencySocial responsesRight temporoparietal junctionEye gaze patternsRight fusiform gyrusPosterior parietal cortexMagnetic resonance imaging researchAnterior cingulate cortexSocial neuroscienceIncongruent trialsAttention circuitsFusiform gyrusCongruent responsesNeural activationBrain networksRight amygdalaSocial functioningEquivalent neural responses in children and adolescents with and without autism during judgments of affect
Wyk B, Hoffman F, Pelphrey KA. Equivalent neural responses in children and adolescents with and without autism during judgments of affect. Developmental Cognitive Neuroscience 2013, 8: 121-130. PMID: 24016745, PMCID: PMC3931746, DOI: 10.1016/j.dcn.2013.08.001.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderCognitive loadNeural activationGreater cognitive loadFunction of taskFunctional connectivity analysisLonger stimulus durationsEmotion processingFMRI taskCondition contrastsNeural responsesSpectrum disorderStimulus durationBehavior measuresConnectivity analysisGroup differencesPrior researchPrevious researchEmotionsTaskChildrenValence levelsIQAutismIndividuals
2012
Action representation in the superior temporal sulcus in children and adults: An fMRI study
Vander Wyk B, Voos A, Pelphrey KA. Action representation in the superior temporal sulcus in children and adults: An fMRI study. Developmental Cognitive Neuroscience 2012, 2: 409-416. PMID: 22727762, PMCID: PMC3431200, DOI: 10.1016/j.dcn.2012.04.004.Peer-Reviewed Original ResearchConceptsSuperior temporal sulcusFunctional magnetic resonance imaging paradigmCongruent trialsTemporal sulcusPosterior superior temporal sulcusIncongruent actionsBiological motionSTS regionFMRI studyAction representationNegative regardImaging paradigmOrder informationHigher-order informationDevelopmental changesOlder childrenChildrenSulcusAdultsTrialsCongruencyRepresentationCongruentPerceptionObjects
2011
Differential brain responses to social exclusion by one's own versus opposite-gender peers
Bolling DZ, Pelphrey KA, Vander Wyk B. Differential brain responses to social exclusion by one's own versus opposite-gender peers. Social Neuroscience 2011, 7: 331-346. PMID: 21981758, PMCID: PMC4520218, DOI: 10.1080/17470919.2011.623181.Peer-Reviewed Original ResearchConceptsCortex activationVentrolateral prefrontal cortex activationImplicit gender attitudesAnterior cingulate cortex activationBall-tossing gameOpposite-gender peersDifferential brain responsesVentrolateral prefrontal cortexSelf-reported distressPrefrontal cortex activationSame-gender peersFunctional magnetic resonanceSocial exclusionSocial cognitionIndividual differencesPsychological threatBrain responsesNeural responsesPeer relationsPrefrontal cortexEmotional benefitsOwn genderOpposite genderGender attitudesCurrent studyResearch Review: Constraining heterogeneity: the social brain and its development in autism spectrum disorder
Pelphrey KA, Shultz S, Hudac CM, Wyk B. Research Review: Constraining heterogeneity: the social brain and its development in autism spectrum disorder. Journal Of Child Psychology And Psychiatry 2011, 52: 631-644. PMID: 21244421, PMCID: PMC3096715, DOI: 10.1111/j.1469-7610.2010.02349.x.Peer-Reviewed Original ResearchMeSH KeywordsAmygdalaBrainBrain MappingChildChild Development Disorders, PervasiveEmotionsEndophenotypesFacial ExpressionFemaleGenetic Predisposition to DiseaseHumansIntentionMagnetic Resonance ImagingMaleNerve NetPattern Recognition, VisualPersonal Construct TheorySocializationTemporal LobeTheory of MindConceptsAutism spectrum disorderSocial information processingSuperior temporal sulcusSpectrum disorderPosterior superior temporal sulcusInformation processingSocial engagementSpecialized neural systemsModel of ASDFunctional neuroimaging researchSocial brainTemporal sulcusBrain mechanismsNeuroimaging researchSocial reciprocityRepetitive behaviorsNeural circuitryNeural systemsBrain endophenotypesDevelopmental studiesDevastating familySocial worldNeurodevelopmental disordersNeural structuresNeuroanatomical structures
2010
Cortical integration of audio–visual speech and non-speech stimuli
Wyk B, Ramsay GJ, Hudac CM, Jones W, Lin D, Klin A, Lee SM, Pelphrey KA. Cortical integration of audio–visual speech and non-speech stimuli. Brain And Cognition 2010, 74: 97-106. PMID: 20709442, PMCID: PMC3869029, DOI: 10.1016/j.bandc.2010.07.002.Peer-Reviewed Original ResearchConceptsLateral occipital cortexUni-modal stimuliNon-speech stimuliAudio-visual speechVisual stimuliOccipital cortexRight inferior frontal gyrusAudio-visual pairingsSimilar auditory stimuliMulti-modal stimuliAudio-visual processingSuperior temporal sulcusInferior frontal gyrusMiddle temporal regionsMiddle temporal gyrusDifferent cortical networksNeural basisTemporal sulcusAuditory stimuliFusiform gyrusFrontal gyrusTemporal gyrusCortical networksCortical integrationTemporal regionsBrain mechanisms for representing what another person sees
Heyda RD, Green SR, Vander Wyk B, Morris JP, Pelphrey KA. Brain mechanisms for representing what another person sees. NeuroImage 2010, 50: 693-700. PMID: 20056152, PMCID: PMC2824003, DOI: 10.1016/j.neuroimage.2009.12.101.Peer-Reviewed Original ResearchConceptsExtrastriate body areaParahippocampal place areaFunctional magnetic resonance imagingSocial cognitionVisual attentionDual-role hypothesisAttribution hypothesisPerson's visual attentionWhole-brain analysisSocial brainStimulus categoriesBrain mechanismsPlace areaVisible stimuliVisual regionsSame stimuliBrain regionsInterest analysisCognitionStimuliParticipants' viewsSpecific categoriesMagnetic resonance imagingExtrastriateHypothesis
2009
Action Understanding in the Superior Temporal Sulcus Region
Vander Wyk BC, Hudac CM, Carter EJ, Sobel DM, Pelphrey KA. Action Understanding in the Superior Temporal Sulcus Region. Psychological Science 2009, 20: 771-777. PMID: 19422619, PMCID: PMC2849148, DOI: 10.1111/j.1467-9280.2009.02359.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAttentionBrain MappingChoice BehaviorColor PerceptionConcept FormationDominance, CerebralEmotionsFemaleHumansImage Processing, Computer-AssistedIntentionMagnetic Resonance ImagingMaleMotion PerceptionOxygenPattern Recognition, VisualPersonal Construct TheoryPsychomotor PerformanceSocial PerceptionTemporal LobeYoung AdultConceptsSuperior temporal sulcus regionEmotional expressionSTS regionPosterior superior temporal sulcus regionSulcus regionFunctional magnetic resonancePosterior STSAction understandingBiological motionEmotional contextNegative emotionsNegative regardPositive regardPerson's motionSocial actCongruentParticipantsIntentionEmotionsObjectsCongruencyPerceptionActionActressMagnetic resonance